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Molecular analysis of katG gene mutations in strains of Mycobacterium tuberculosis complex from Africa

A sample of 124 isoniazid (INH)-resistant and 88 susceptible strains of Mycobacterium tuberculosis complex from south, central, and west Africa was analyzed by direct sequence analysis and PCR-restriction fragment length polymorphism analysis of their catalase-peroxidase (katG) genes. Point mutation...

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Hauptverfasser: Haas, Walter (VerfasserIn) , Schilke, Kathrin (VerfasserIn) , Brand, J. (VerfasserIn) , Amthor, Beate (VerfasserIn) , Weyer, K. (VerfasserIn) , Fourie, P. B. (VerfasserIn) , Bretzel, Gisela (VerfasserIn) , Sticht-Groh, Veronica (VerfasserIn) , Bremer, Hans J. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 1 July 1997
In: Antimicrobial agents and chemotherapy
Year: 1997, Jahrgang: 41, Heft: 7, Pages: 1601-1603
ISSN:1098-6596
DOI:10.1128/aac.41.7.1601
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1128/aac.41.7.1601
Verlag, lizenzpflichtig, Volltext: https://journals.asm.org/doi/10.1128/aac.41.7.1601
Volltext
Verfasserangaben:WH Haas, K Schilke, J Brand, B Amthor, K Weyer, PB Fourie, G Bretzel, V Sticht-Groh, HJ Bremer
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Zusammenfassung:A sample of 124 isoniazid (INH)-resistant and 88 susceptible strains of Mycobacterium tuberculosis complex from south, central, and west Africa was analyzed by direct sequence analysis and PCR-restriction fragment length polymorphism analysis of their catalase-peroxidase (katG) genes. Point mutations at codon 315 were found in the genomes of 64% of INH-resistant strains, but no complete deletions were identified. Mutations at codon 463 were independent of INH resistance and were linked to the geographic origins of the strains.
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Beschreibung:Online Resource
ISSN:1098-6596
DOI:10.1128/aac.41.7.1601

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