Molecular analysis of katG gene mutations in strains of Mycobacterium tuberculosis complex from Africa
A sample of 124 isoniazid (INH)-resistant and 88 susceptible strains of Mycobacterium tuberculosis complex from south, central, and west Africa was analyzed by direct sequence analysis and PCR-restriction fragment length polymorphism analysis of their catalase-peroxidase (katG) genes. Point mutation...
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| Hauptverfasser: | , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
1 July 1997
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| In: |
Antimicrobial agents and chemotherapy
Year: 1997, Jahrgang: 41, Heft: 7, Pages: 1601-1603 |
| ISSN: | 1098-6596 |
| DOI: | 10.1128/aac.41.7.1601 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1128/aac.41.7.1601 Verlag, lizenzpflichtig, Volltext: https://journals.asm.org/doi/10.1128/aac.41.7.1601 
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| Verfasserangaben: | WH Haas, K Schilke, J Brand, B Amthor, K Weyer, PB Fourie, G Bretzel, V Sticht-Groh, HJ Bremer |
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| 520 | |a A sample of 124 isoniazid (INH)-resistant and 88 susceptible strains of Mycobacterium tuberculosis complex from south, central, and west Africa was analyzed by direct sequence analysis and PCR-restriction fragment length polymorphism analysis of their catalase-peroxidase (katG) genes. Point mutations at codon 315 were found in the genomes of 64% of INH-resistant strains, but no complete deletions were identified. Mutations at codon 463 were independent of INH resistance and were linked to the geographic origins of the strains. | ||
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