Ratiometric fluorescent sensing of pyrophosphate with sp³-functionalized single-walled carbon nanotubes
Inorganic pyrophosphate is a key molecule in many biological processes from DNA synthesis to cell metabolism. Here we introduce sp3-functionalized (6,5) single-walled carbon nanotubes (SWNTs) with red-shifted defect emission as near-infrared luminescent probes for the optical detection and quantific...
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| Hauptverfasser: | , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
24 January 2024
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| In: |
Nature Communications
Year: 2024, Jahrgang: 15, Pages: 1-13 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-024-45052-1 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41467-024-45052-1 Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-024-45052-1 
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| Verfasserangaben: | Simon Settele, C. Alexander Schrage, Sebastian Jung, Elena Michel, Han Li, Benjamin S. Flavel, A. Stephen K. Hashmi, Sebastian Kruss & Jana Zaumseil |
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| 520 | |a Inorganic pyrophosphate is a key molecule in many biological processes from DNA synthesis to cell metabolism. Here we introduce sp3-functionalized (6,5) single-walled carbon nanotubes (SWNTs) with red-shifted defect emission as near-infrared luminescent probes for the optical detection and quantification of inorganic pyrophosphate. The sensing scheme is based on the immobilization of Cu2+ ions on the SWNT surface promoted by coordination to covalently attached aryl alkyne groups and a triazole complex. The presence of Cu2+ ions on the SWNT surface causes fluorescence quenching via photoinduced electron transfer, which is reversed by copper-complexing analytes such as pyrophosphate. The differences in the fluorescence response of sp3-defect to pristine nanotube emission enables reproducible ratiometric measurements in a wide concentration window. Biocompatible, phospholipid-polyethylene glycol-coated SWNTs with such sp3 defects are employed for the detection of pyrophosphate in cell lysate and for monitoring the progress of DNA synthesis in a polymerase chain reaction. This robust ratiometric and near-infrared luminescent probe for pyrophosphate may serve as a starting point for the rational design of nanotube-based biosensors. | ||
| 650 | 4 | |a Carbon nanotubes and fullerenes | |
| 650 | 4 | |a Fluorescence spectroscopy | |
| 650 | 4 | |a Fluorescent probes | |
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