Structure-changeable luminescent Eu(III) complex as a human cancer grade probing system for brain tumor diagnosis
Accurate determination of human tumor malignancy is important for choosing efficient and safe therapies. Bioimaging technologies based on luminescent molecules are widely used to localize and distinguish active tumor cells. Here, we report a human cancer grade probing system (GPS) using a water-solu...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
22 January 2024
|
| In: |
Scientific reports
Year: 2024, Jahrgang: 14, Pages: 1-8 |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-023-50138-9 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41598-023-50138-9 Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41598-023-50138-9 
|
| Verfasserangaben: | Mengfei Wang, Masaya Kono, Yusaku Yamaguchi, Jahidul Islam, Sunao Shoji, Yuichi Kitagawa, Koji Fushimi, Sora Watanabe, Go Matsuba, Akihisa Yamamoto, Motomu Tanaka, Masumi Tsuda, Shinya Tanaka & Yasuchika Hasegawa |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1892005646 | ||
| 003 | DE-627 | ||
| 005 | 20241205143553.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240621s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41598-023-50138-9 |2 doi | |
| 035 | |a (DE-627)1892005646 | ||
| 035 | |a (DE-599)KXP1892005646 | ||
| 035 | |a (OCoLC)1475300355 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 30 |2 sdnb | ||
| 100 | 1 | |a Wang, Mengfei |e VerfasserIn |0 (DE-588)1333693184 |0 (DE-627)1892007800 |4 aut | |
| 245 | 1 | 0 | |a Structure-changeable luminescent Eu(III) complex as a human cancer grade probing system for brain tumor diagnosis |c Mengfei Wang, Masaya Kono, Yusaku Yamaguchi, Jahidul Islam, Sunao Shoji, Yuichi Kitagawa, Koji Fushimi, Sora Watanabe, Go Matsuba, Akihisa Yamamoto, Motomu Tanaka, Masumi Tsuda, Shinya Tanaka & Yasuchika Hasegawa |
| 264 | 1 | |c 22 January 2024 | |
| 300 | |b Illustrationen | ||
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 21.06.2024 | ||
| 520 | |a Accurate determination of human tumor malignancy is important for choosing efficient and safe therapies. Bioimaging technologies based on luminescent molecules are widely used to localize and distinguish active tumor cells. Here, we report a human cancer grade probing system (GPS) using a water-soluble and structure-changeable Eu(III) complex for the continuous detection of early human brain tumors of different malignancy grades. Time-dependent emission spectra of the Eu(III) complexes in various types of tumor cells were recorded. The radiative rate constants (kr), which depend on the geometry of the Eu(III) complex, were calculated from the emission spectra. The tendency of the kr values to vary depended on the tumor cells at different malignancy grades. Between T = 0 and T = 3 h of invasion, the kr values exhibited an increase of 4% in NHA/TS (benign grade II gliomas), 7% in NHA/TSR (malignant grade III gliomas), and 27% in NHA/TSRA (malignant grade IV gliomas). Tumor cells with high-grade malignancy exhibited a rapid upward trend in kr values. The cancer GPS employs Eu(III) emissions to provide a new diagnostic method for determining human brain tumor malignancy. | ||
| 650 | 4 | |a Diagnostic markers | |
| 650 | 4 | |a Fluorescent probes | |
| 700 | 1 | |a Kono, Masaya |e VerfasserIn |4 aut | |
| 700 | 1 | |a Yamaguchi, Yusaku |e VerfasserIn |4 aut | |
| 700 | 1 | |a Islam, Jahidul |e VerfasserIn |4 aut | |
| 700 | 1 | |a Shoji, Sunao |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kitagawa, Yuichi |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fushimi, Koji |e VerfasserIn |4 aut | |
| 700 | 1 | |a Watanabe, Sora |e VerfasserIn |4 aut | |
| 700 | 1 | |a Matsuba, Go |e VerfasserIn |4 aut | |
| 700 | 1 | |a Yamamoto, Akihisa |e VerfasserIn |4 aut | |
| 700 | 1 | |a Tanaka, Motomu |e VerfasserIn |0 (DE-588)1060648377 |0 (DE-627)800414829 |0 (DE-576)416774636 |4 aut | |
| 700 | 1 | |a Tsuda, Masumi |e VerfasserIn |4 aut | |
| 700 | 1 | |a Tanaka, Shinya |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hasegawa, Yasuchika |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Scientific reports |d [London] : Springer Nature, 2011 |g 14(2024), Artikel-ID 778, Seite 1-8 |h Online-Ressource |w (DE-627)663366712 |w (DE-600)2615211-3 |w (DE-576)346641179 |x 2045-2322 |7 nnas |a Structure-changeable luminescent Eu(III) complex as a human cancer grade probing system for brain tumor diagnosis |
| 773 | 1 | 8 | |g volume:14 |g year:2024 |g elocationid:778 |g pages:1-8 |g extent:8 |a Structure-changeable luminescent Eu(III) complex as a human cancer grade probing system for brain tumor diagnosis |
| 856 | 4 | 0 | |u https://doi.org/10.1038/s41598-023-50138-9 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/s41598-023-50138-9 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20240621 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 1060648377 |a Tanaka, Motomu |m 1060648377:Tanaka, Motomu |d 120000 |d 120300 |e 120000PT1060648377 |e 120300PT1060648377 |k 0/120000/ |k 1/120000/120300/ |p 11 | ||
| 999 | |a KXP-PPN1892005646 |e 4541071703 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedKey":"2024","dateIssuedDisp":"22 January 2024"}],"note":["Gesehen am 21.06.2024"],"title":[{"title":"Structure-changeable luminescent Eu(III) complex as a human cancer grade probing system for brain tumor diagnosis","title_sort":"Structure-changeable luminescent Eu(III) complex as a human cancer grade probing system for brain tumor diagnosis"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"person":[{"display":"Wang, Mengfei","family":"Wang","given":"Mengfei","role":"aut"},{"given":"Masaya","role":"aut","display":"Kono, Masaya","family":"Kono"},{"display":"Yamaguchi, Yusaku","family":"Yamaguchi","role":"aut","given":"Yusaku"},{"family":"Islam","display":"Islam, Jahidul","given":"Jahidul","role":"aut"},{"given":"Sunao","role":"aut","display":"Shoji, Sunao","family":"Shoji"},{"given":"Yuichi","role":"aut","display":"Kitagawa, Yuichi","family":"Kitagawa"},{"role":"aut","given":"Koji","display":"Fushimi, Koji","family":"Fushimi"},{"role":"aut","given":"Sora","family":"Watanabe","display":"Watanabe, Sora"},{"role":"aut","given":"Go","family":"Matsuba","display":"Matsuba, Go"},{"given":"Akihisa","role":"aut","display":"Yamamoto, Akihisa","family":"Yamamoto"},{"given":"Motomu","role":"aut","display":"Tanaka, Motomu","family":"Tanaka"},{"role":"aut","given":"Masumi","family":"Tsuda","display":"Tsuda, Masumi"},{"display":"Tanaka, Shinya","family":"Tanaka","role":"aut","given":"Shinya"},{"family":"Hasegawa","display":"Hasegawa, Yasuchika","role":"aut","given":"Yasuchika"}],"relHost":[{"recId":"663366712","pubHistory":["1, article number 1 (2011)-"],"physDesc":[{"extent":"Online-Ressource"}],"id":{"zdb":["2615211-3"],"eki":["663366712"],"issn":["2045-2322"]},"disp":"Structure-changeable luminescent Eu(III) complex as a human cancer grade probing system for brain tumor diagnosisScientific reports","language":["eng"],"part":{"pages":"1-8","text":"14(2024), Artikel-ID 778, Seite 1-8","year":"2024","volume":"14","extent":"8"},"note":["Gesehen am 12.07.24"],"origin":[{"publisherPlace":"[London] ; London","dateIssuedDisp":"2011-","publisher":"Springer Nature ; Nature Publishing Group","dateIssuedKey":"2011"}],"title":[{"title":"Scientific reports","title_sort":"Scientific reports"}],"type":{"bibl":"periodical","media":"Online-Ressource"}}],"id":{"doi":["10.1038/s41598-023-50138-9"],"eki":["1892005646"]},"name":{"displayForm":["Mengfei Wang, Masaya Kono, Yusaku Yamaguchi, Jahidul Islam, Sunao Shoji, Yuichi Kitagawa, Koji Fushimi, Sora Watanabe, Go Matsuba, Akihisa Yamamoto, Motomu Tanaka, Masumi Tsuda, Shinya Tanaka & Yasuchika Hasegawa"]},"physDesc":[{"extent":"8 S.","noteIll":"Illustrationen"}],"recId":"1892005646"} | ||
| SRT | |a WANGMENGFESTRUCTUREC2220 | ||