Hypoxia sensing and responses in Parkinson’s disease
Parkinson’s disease (PD) is associated with various deficits in sensing and responding to reductions in oxygen availability (hypoxia). Here we summarize the evidence pointing to a central role of hypoxia in PD, discuss the relation of hypoxia and oxygen dependence with pathological hallmarks of PD,...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
1 February 2024
|
| In: |
International journal of molecular sciences
Year: 2024, Volume: 25, Issue: 3, Pages: 1-13 |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms25031759 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/ijms25031759 Verlag, kostenfrei, Volltext: https://www.mdpi.com/1422-0067/25/3/1759 
|
| Author Notes: | Johannes Burtscher, Yves Duderstadt, Hannes Gatterer, Martin Burtscher, Roman Vozdek, Grégoire P. Millet, Andrew A. Hicks, Hannelore Ehrenreich and Martin Kopp |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1892008556 | ||
| 003 | DE-627 | ||
| 005 | 20241205143613.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240621s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/ijms25031759 |2 doi | |
| 035 | |a (DE-627)1892008556 | ||
| 035 | |a (DE-599)KXP1892008556 | ||
| 035 | |a (OCoLC)1475300375 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Burtscher, Johannes |e VerfasserIn |0 (DE-588)1333700253 |0 (DE-627)1892011794 |4 aut | |
| 245 | 1 | 0 | |a Hypoxia sensing and responses in Parkinson’s disease |c Johannes Burtscher, Yves Duderstadt, Hannes Gatterer, Martin Burtscher, Roman Vozdek, Grégoire P. Millet, Andrew A. Hicks, Hannelore Ehrenreich and Martin Kopp |
| 264 | 1 | |c 1 February 2024 | |
| 300 | |b Illustrationen | ||
| 300 | |a 13 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 21.06.2024 | ||
| 520 | |a Parkinson’s disease (PD) is associated with various deficits in sensing and responding to reductions in oxygen availability (hypoxia). Here we summarize the evidence pointing to a central role of hypoxia in PD, discuss the relation of hypoxia and oxygen dependence with pathological hallmarks of PD, including mitochondrial dysfunction, dopaminergic vulnerability, and alpha-synuclein-related pathology, and highlight the link with cellular and systemic oxygen sensing. We describe cases suggesting that hypoxia may trigger Parkinsonian symptoms but also emphasize that the endogenous systems that protect from hypoxia can be harnessed to protect from PD. Finally, we provide examples of preclinical and clinical research substantiating this potential. | ||
| 650 | 4 | |a hypoxia | |
| 650 | 4 | |a mitochondria | |
| 650 | 4 | |a neurodegeneration | |
| 650 | 4 | |a Parkinson’s disease | |
| 650 | 4 | |a respiratory diseases | |
| 650 | 4 | |a synuclein | |
| 700 | 1 | |a Duderstadt, Yves |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gatterer, Hannes |e VerfasserIn |4 aut | |
| 700 | 1 | |a Burtscher, Martin |d 1951- |e VerfasserIn |0 (DE-588)112681425 |0 (DE-627)732699428 |0 (DE-576)376590998 |4 aut | |
| 700 | 1 | |a Vozdek, Roman |e VerfasserIn |4 aut | |
| 700 | 1 | |a Millet, Grégoire |e VerfasserIn |0 (DE-588)1261048288 |0 (DE-627)1891413376 |4 aut | |
| 700 | 1 | |a Hicks, Andrew A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ehrenreich, Hannelore |d 1955- |e VerfasserIn |0 (DE-588)131459910 |0 (DE-627)50945755X |0 (DE-576)298491982 |4 aut | |
| 700 | 1 | |a Kopp, Martin |d 1967- |e VerfasserIn |0 (DE-588)1196723818 |0 (DE-627)1678563455 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of molecular sciences |d Basel : Molecular Diversity Preservation International, 2000 |g 25(2024), 3, Artikel-ID 1759, Seite 1-13 |h Online-Ressource |w (DE-627)316340715 |w (DE-600)2019364-6 |w (DE-576)281194653 |x 1422-0067 |7 nnas |a Hypoxia sensing and responses in Parkinson’s disease |
| 773 | 1 | 8 | |g volume:25 |g year:2024 |g number:3 |g elocationid:1759 |g pages:1-13 |g extent:13 |a Hypoxia sensing and responses in Parkinson’s disease |
| 856 | 4 | 0 | |u https://doi.org/10.3390/ijms25031759 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.mdpi.com/1422-0067/25/3/1759 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20240621 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 131459910 |a Ehrenreich, Hannelore |m 131459910:Ehrenreich, Hannelore |p 8 | ||
| 999 | |a KXP-PPN1892008556 |e 4541101955 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"physDesc":[{"noteIll":"Illustrationen","extent":"13 S."}],"relHost":[{"language":["eng"],"recId":"316340715","type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Hypoxia sensing and responses in Parkinson’s diseaseInternational journal of molecular sciences","note":["Gesehen am 17.09.20"],"titleAlt":[{"title":"IJMS"}],"part":{"issue":"3","pages":"1-13","year":"2024","extent":"13","text":"25(2024), 3, Artikel-ID 1759, Seite 1-13","volume":"25"},"pubHistory":["1.2000 -"],"title":[{"title":"International journal of molecular sciences","title_sort":"International journal of molecular sciences"}],"physDesc":[{"extent":"Online-Ressource"}],"id":{"eki":["316340715"],"zdb":["2019364-6"],"issn":["1422-0067","1661-6596"]},"origin":[{"publisherPlace":"Basel","dateIssuedDisp":"2000-","publisher":"Molecular Diversity Preservation International","dateIssuedKey":"2000"}]}],"origin":[{"dateIssuedKey":"2024","dateIssuedDisp":"1 February 2024"}],"id":{"doi":["10.3390/ijms25031759"],"eki":["1892008556"]},"name":{"displayForm":["Johannes Burtscher, Yves Duderstadt, Hannes Gatterer, Martin Burtscher, Roman Vozdek, Grégoire P. Millet, Andrew A. Hicks, Hannelore Ehrenreich and Martin Kopp"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 21.06.2024"],"language":["eng"],"recId":"1892008556","title":[{"title_sort":"Hypoxia sensing and responses in Parkinson’s disease","title":"Hypoxia sensing and responses in Parkinson’s disease"}],"person":[{"roleDisplay":"VerfasserIn","display":"Burtscher, Johannes","role":"aut","family":"Burtscher","given":"Johannes"},{"family":"Duderstadt","given":"Yves","display":"Duderstadt, Yves","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Hannes","family":"Gatterer","role":"aut","display":"Gatterer, Hannes","roleDisplay":"VerfasserIn"},{"display":"Burtscher, Martin","roleDisplay":"VerfasserIn","role":"aut","family":"Burtscher","given":"Martin"},{"role":"aut","display":"Vozdek, Roman","roleDisplay":"VerfasserIn","given":"Roman","family":"Vozdek"},{"given":"Grégoire","family":"Millet","role":"aut","roleDisplay":"VerfasserIn","display":"Millet, Grégoire"},{"roleDisplay":"VerfasserIn","display":"Hicks, Andrew A.","role":"aut","family":"Hicks","given":"Andrew A."},{"role":"aut","display":"Ehrenreich, Hannelore","roleDisplay":"VerfasserIn","given":"Hannelore","family":"Ehrenreich"},{"given":"Martin","family":"Kopp","role":"aut","roleDisplay":"VerfasserIn","display":"Kopp, Martin"}]} | ||
| SRT | |a BURTSCHERJHYPOXIASEN1202 | ||