Interactions of the Trypanosoma brucei brucei zinc-finger-domain protein ZC3H28
, - In Trypanosoma brucei and related Kinetoplastids, regulation of gene expression occurs mostly post-transcriptionally, and RNA-binding proteins play a critical role in the regulation of mRNA and protein abundance. Trypanosoma brucei ZC3H28 is a 114 KDa cytoplasmic mRNA-binding protein with a sin...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
March 2022
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| In: |
Parasitology
Year: 2022, Volume: 149, Issue: 3, Pages: 356-370 |
| ISSN: | 1469-8161 |
| DOI: | 10.1017/S003118202100189X |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1017/S003118202100189X Verlag, kostenfrei, Volltext: https://www.cambridge.org/core/journals/parasitology/article/interactions-of-the-trypanosoma-brucei-brucei-zincfingerdomain-protein-zc3h28/B4407AB7BFDDE4D0BC388F133A7B67BA 
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| Author Notes: | Tania Bishola Tshitenge and Christine Clayton |
MARC
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| 520 | |a , - In Trypanosoma brucei and related Kinetoplastids, regulation of gene expression occurs mostly post-transcriptionally, and RNA-binding proteins play a critical role in the regulation of mRNA and protein abundance. Trypanosoma brucei ZC3H28 is a 114 KDa cytoplasmic mRNA-binding protein with a single C(x)7C(x)5C(x)sH zinc finger at the C-terminus and numerous proline-, histidine- or glutamine-rich regions. ZC3H28 is essential for normal bloodstream-form trypanosome growth, and when tethered to a reporter mRNA, ZC3H28 increased reporter mRNA and protein levels. Purification of N-terminally tagged ZC3H28 followed by mass spectrometry showed enrichment of ribosomal proteins, various RNA-binding proteins including both poly(A) binding proteins, the translation initiation complex EIF4E4/EIF4G3, and the activator MKT1. Tagged ZC3H28 was preferentially associated with long RNAs that have low complexity sequences in their 3′-untranslated regions; their coding regions also have low ribosome densities. In agreement with the tethering results, after ZC3H28 depletion, the levels of a significant proportion of its bound mRNAs decreased. We suggest that ZC3H28 is implicated in the stabilization of long mRNAs that are poorly translated. | ||
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