Global estimates on the number of persons across the Alzheimer's disease continuum
Abstract Introduction Global estimates on numbers of persons in early stages of Alzheimer's disease (AD), including prodromal and preclinical, are lacking, yet are needed to inform policy decisions on preventive measures and planning for future therapies targeting AD pathology. Methods We synth...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
February 2023
|
| In: |
Alzheimer's and dementia
Year: 2023, Volume: 19, Issue: 2, Pages: 658-670 |
| ISSN: | 1552-5279 |
| DOI: | 10.1002/alz.12694 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1002/alz.12694 Verlag, kostenfrei, Volltext: http://alz.journals.onlinelibrary.wiley.com/doi/10.1002/alz.12694 
|
| Author Notes: | Anders Gustavsson, Nicholas Norton, Thomas Fast, Lutz Frölich, Jean Georges, Drew Holzapfel, Tunahan Kirabali, Pierre Krolak-Salmon, Paolo M. Rossini, Maria Teresa Ferretti, Lydia Lanman, Antonella Santuccione Chadha, Wiesje M. van der Flier |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1892135493 | ||
| 003 | DE-627 | ||
| 005 | 20241205144035.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240625s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/alz.12694 |2 doi | |
| 035 | |a (DE-627)1892135493 | ||
| 035 | |a (DE-599)KXP1892135493 | ||
| 035 | |a (OCoLC)1475300597 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Gustavsson, Anders |e VerfasserIn |0 (DE-588)1333945671 |0 (DE-627)1892135884 |4 aut | |
| 245 | 1 | 0 | |a Global estimates on the number of persons across the Alzheimer's disease continuum |c Anders Gustavsson, Nicholas Norton, Thomas Fast, Lutz Frölich, Jean Georges, Drew Holzapfel, Tunahan Kirabali, Pierre Krolak-Salmon, Paolo M. Rossini, Maria Teresa Ferretti, Lydia Lanman, Antonella Santuccione Chadha, Wiesje M. van der Flier |
| 264 | 1 | |c February 2023 | |
| 300 | |a 13 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Erstmals veröffentlicht: 02. Juni 2022 | ||
| 500 | |a Gesehen am 25.06.2024 | ||
| 520 | |a Abstract Introduction Global estimates on numbers of persons in early stages of Alzheimer's disease (AD), including prodromal and preclinical, are lacking, yet are needed to inform policy decisions on preventive measures and planning for future therapies targeting AD pathology. Methods We synthesized the literature on prevalence across the AD continuum and derived a model estimating the number of persons, stratified by 5-year age groups, sex, and disease stage (AD dementia, prodromal AD, and preclinical AD). Results The global number of persons with AD dementia, prodromal AD, and preclinical AD were estimated at 32, 69, and 315 million, respectively. Together they constituted 416 million across the AD continuum, or 22% of all persons aged 50 and above. Discussion Considering predementia stages, the number of persons with AD is much larger than conveyed in available literature. Our estimates are uncertain, especially for predementia stages in low- and middle-income regions where biomarker studies are missing. | ||
| 650 | 4 | |a Alzheimer's disease | |
| 650 | 4 | |a preclinical | |
| 650 | 4 | |a prevalence | |
| 650 | 4 | |a prevention | |
| 650 | 4 | |a prodromal | |
| 700 | 1 | |a Norton, Nicholas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fast, Thomas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Frölich, Lutz |d 1956- |e VerfasserIn |0 (DE-588)1028327099 |0 (DE-627)730567516 |0 (DE-576)375813160 |4 aut | |
| 700 | 1 | |a Georges, Jean |e VerfasserIn |4 aut | |
| 700 | 1 | |a Holzapfel, Drew |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kirabali, Tunahan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Krolak-Salmon, Pierre |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rossini, Paolo M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ferretti, Maria Teresa |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lanman, Lydia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Chadha, Antonella Santuccione |e VerfasserIn |4 aut | |
| 700 | 1 | |a van der Flier, Wiesje M. |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Alzheimer's and dementia |d Hoboken, NJ : Wiley, 2005 |g 19(2023), 2 vom: Feb., Seite 658-670 |h Online-Ressource |w (DE-627)499546059 |w (DE-600)2201940-6 |w (DE-576)255666330 |x 1552-5279 |7 nnas |a Global estimates on the number of persons across the Alzheimer's disease continuum |
| 773 | 1 | 8 | |g volume:19 |g year:2023 |g number:2 |g month:02 |g pages:658-670 |g extent:13 |a Global estimates on the number of persons across the Alzheimer's disease continuum |
| 856 | 4 | 0 | |u https://doi.org/10.1002/alz.12694 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u http://alz.journals.onlinelibrary.wiley.com/doi/10.1002/alz.12694 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20240625 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 1028327099 |a Frölich, Lutz |m 1028327099:Frölich, Lutz |d 60000 |e 60000PF1028327099 |k 0/60000/ |p 4 | ||
| 999 | |a KXP-PPN1892135493 |e 4541478536 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedKey":"2023","dateIssuedDisp":"February 2023"}],"note":["Erstmals veröffentlicht: 02. Juni 2022","Gesehen am 25.06.2024"],"title":[{"title":"Global estimates on the number of persons across the Alzheimer's disease continuum","title_sort":"Global estimates on the number of persons across the Alzheimer's disease continuum"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"name":{"displayForm":["Anders Gustavsson, Nicholas Norton, Thomas Fast, Lutz Frölich, Jean Georges, Drew Holzapfel, Tunahan Kirabali, Pierre Krolak-Salmon, Paolo M. Rossini, Maria Teresa Ferretti, Lydia Lanman, Antonella Santuccione Chadha, Wiesje M. van der Flier"]},"physDesc":[{"extent":"13 S."}],"recId":"1892135493","relHost":[{"disp":"Global estimates on the number of persons across the Alzheimer's disease continuumAlzheimer's and dementia","type":{"media":"Online-Ressource","bibl":"periodical"},"pubHistory":["1.2005 -"],"origin":[{"dateIssuedDisp":"2005-","publisher":"Wiley ; Elsevier","dateIssuedKey":"2005","publisherPlace":"Hoboken, NJ ; Amsterdam"}],"note":["Gesehen am 19.03.2024"],"title":[{"title_sort":"Alzheimer's and dementia","subtitle":"the journal of the Alzheimer's Association","title":"Alzheimer's and dementia"}],"id":{"doi":["10.1002/(ISSN)1552-5279"],"zdb":["2201940-6"],"issn":["1552-5279"],"eki":["499546059"]},"recId":"499546059","physDesc":[{"extent":"Online-Ressource"}],"part":{"text":"19(2023), 2 vom: Feb., Seite 658-670","issue":"2","year":"2023","pages":"658-670","volume":"19","extent":"13"},"language":["eng"]}],"id":{"doi":["10.1002/alz.12694"],"eki":["1892135493"]},"person":[{"given":"Anders","role":"aut","display":"Gustavsson, Anders","family":"Gustavsson"},{"display":"Norton, Nicholas","family":"Norton","role":"aut","given":"Nicholas"},{"display":"Fast, Thomas","family":"Fast","given":"Thomas","role":"aut"},{"display":"Frölich, Lutz","family":"Frölich","role":"aut","given":"Lutz"},{"display":"Georges, Jean","family":"Georges","given":"Jean","role":"aut"},{"given":"Drew","role":"aut","display":"Holzapfel, Drew","family":"Holzapfel"},{"role":"aut","given":"Tunahan","display":"Kirabali, Tunahan","family":"Kirabali"},{"family":"Krolak-Salmon","display":"Krolak-Salmon, Pierre","role":"aut","given":"Pierre"},{"family":"Rossini","display":"Rossini, Paolo M.","given":"Paolo M.","role":"aut"},{"given":"Maria Teresa","role":"aut","family":"Ferretti","display":"Ferretti, Maria Teresa"},{"display":"Lanman, Lydia","family":"Lanman","given":"Lydia","role":"aut"},{"given":"Antonella Santuccione","role":"aut","display":"Chadha, Antonella Santuccione","family":"Chadha"},{"given":"Wiesje M.","role":"aut","display":"van der Flier, Wiesje M.","family":"van der Flier"}],"language":["eng"]} | ||
| SRT | |a GUSTAVSSONGLOBALESTI2023 | ||