Do we need MRI in all biopsy naïve patients?: a multicenter cohort analysis
Purpose: The combined approach (CB) of magnetic resonance imaging (MRI)-guided biopsy (TB) and systematic biopsy (SB) is strongly recommended based on numerous studies in biopsy naïve men with suspicion of clinically significant prostate cancer (csPCA). However, the unbalanced accessibility of MRI,...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
07 February 2024
|
| In: |
World journal of urology
Year: 2024, Jahrgang: 42, Pages: 1-7 |
| ISSN: | 1433-8726 |
| DOI: | 10.1007/s00345-024-04780-1 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00345-024-04780-1
|
| Verfasserangaben: | Philipp Krausewitz, Angelika Borkowetz, Gernot Ortner, Kira Kornienko, Mike Wenzel, Niklas Westhoff, GESRU Academics Prostate Cancer Group |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1892137690 | ||
| 003 | DE-627 | ||
| 005 | 20251127232354.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240625s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00345-024-04780-1 |2 doi | |
| 035 | |a (DE-627)1892137690 | ||
| 035 | |a (DE-599)KXP1892137690 | ||
| 035 | |a (OCoLC)1475300670 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Krausewitz, Philipp |d 1990- |e VerfasserIn |0 (DE-588)1081963190 |0 (DE-627)846927926 |0 (DE-576)454999968 |4 aut | |
| 245 | 1 | 0 | |a Do we need MRI in all biopsy naïve patients? |b a multicenter cohort analysis |c Philipp Krausewitz, Angelika Borkowetz, Gernot Ortner, Kira Kornienko, Mike Wenzel, Niklas Westhoff, GESRU Academics Prostate Cancer Group |
| 264 | 1 | |c 07 February 2024 | |
| 300 | |b Illustrationen | ||
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 25.06.2024 | ||
| 520 | |a Purpose: The combined approach (CB) of magnetic resonance imaging (MRI)-guided biopsy (TB) and systematic biopsy (SB) is strongly recommended based on numerous studies in biopsy naïve men with suspicion of clinically significant prostate cancer (csPCA). However, the unbalanced accessibility of MRI, challenges related to reimbursement and the scarcity of specialized medical practitioners continue to impede a widespread implementation. Therefore, our objective was to determine a subset of men that could undergo SB without an increased risk of underdiagnosis at reduced expenses. Methods: A multicenter analysis of 2714 men with confirmed PCA and suspicious MRI who underwent CB were enrolled. Cancer detection rates were compared between the different biopsy routes SB, TB and CB using McNemar paired test. Additionally, Gleason grade up- and down-grading was determined. Results: CB detected more csPCA than TB and SB (p < 0.001), irrespective of MRI findings or biopsy route (transperineal vs. transrectal). Thereby, single biopsy approaches misgraded > 50% of csPCA. TB showed higher diagnostic efficiency, defined as csPCA detection per biopsy core than CB and SB (p < 0.001). For patients with abnormal DRE and PSA levels > 12.5 ng/ml, PSAD > 0.35 ng/ml/cm3, or > 75 years, SB and CB showed similar csPCA detection rates. Conclusion: Conducting CB provides the highest level of diagnostic certainty and minimizes the risk of underdiagnosis in almost all biopsy-naive men. However, in patients with suspicious DRE and high PSA levels, PSAD, or advanced age solely using SB leads to similar csPCA detection rates. Thus, a reduced biopsy protocol may be considered for these men in case resources are limited. | ||
| 650 | 4 | |a Biopsy method | |
| 650 | 4 | |a Clinically significant prostate cancer | |
| 650 | 4 | |a MRI | |
| 650 | 4 | |a Systematic biopsy | |
| 700 | 1 | |a Borkowetz, Angelika |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ortner, Gernot |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kornienko, Kira |e VerfasserIn |4 aut | |
| 700 | 1 | |8 1\p |a Wenzel, Mike |d 1991- |e VerfasserIn |0 (DE-588)1173350659 |0 (DE-627)1042480494 |0 (DE-576)515171514 |4 aut | |
| 700 | 1 | |a Westhoff, Niklas Christian |d 1988- |e VerfasserIn |0 (DE-588)107322306X |0 (DE-627)828672628 |0 (DE-576)434741752 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t World journal of urology |d Berlin : Springer, 1983 |g 42(2024), Artikel-ID 73, Seite 1-7 |h Online-Ressource |w (DE-627)254910874 |w (DE-600)1463303-6 |w (DE-576)074754505 |x 1433-8726 |7 nnas |a Do we need MRI in all biopsy naïve patients? a multicenter cohort analysis |
| 773 | 1 | 8 | |g volume:42 |g year:2024 |g elocationid:73 |g pages:1-7 |g extent:7 |a Do we need MRI in all biopsy naïve patients? a multicenter cohort analysis |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00345-024-04780-1 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 883 | |8 1\p |a cgwrk |d 20251101 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 951 | |a AR | ||
| 992 | |a 20240625 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 107322306X |a Westhoff, Niklas Christian |m 107322306X:Westhoff, Niklas Christian |d 60000 |d 63100 |e 60000PW107322306X |e 63100PW107322306X |k 0/60000/ |k 1/60000/63100/ |p 6 |y j | ||
| 999 | |a KXP-PPN1892137690 |e 4541483092 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"family":"Krausewitz","given":"Philipp","role":"aut","display":"Krausewitz, Philipp","roleDisplay":"VerfasserIn"},{"given":"Angelika","family":"Borkowetz","display":"Borkowetz, Angelika","role":"aut","roleDisplay":"VerfasserIn"},{"given":"Gernot","family":"Ortner","roleDisplay":"VerfasserIn","display":"Ortner, Gernot","role":"aut"},{"family":"Kornienko","given":"Kira","roleDisplay":"VerfasserIn","role":"aut","display":"Kornienko, Kira"},{"role":"aut","display":"Wenzel, Mike","roleDisplay":"VerfasserIn","family":"Wenzel","given":"Mike"},{"family":"Westhoff","given":"Niklas Christian","roleDisplay":"VerfasserIn","display":"Westhoff, Niklas Christian","role":"aut"}],"name":{"displayForm":["Philipp Krausewitz, Angelika Borkowetz, Gernot Ortner, Kira Kornienko, Mike Wenzel, Niklas Westhoff, GESRU Academics Prostate Cancer Group"]},"note":["Gesehen am 25.06.2024"],"physDesc":[{"extent":"7 S.","noteIll":"Illustrationen"}],"recId":"1892137690","id":{"eki":["1892137690"],"doi":["10.1007/s00345-024-04780-1"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"relHost":[{"title":[{"title_sort":"World journal of urology","title":"World journal of urology"}],"origin":[{"publisher":"Springer","dateIssuedDisp":"1983-","dateIssuedKey":"1983","publisherPlace":"Berlin ; Heidelberg"}],"disp":"Do we need MRI in all biopsy naïve patients? a multicenter cohort analysisWorld journal of urology","part":{"year":"2024","pages":"1-7","extent":"7","volume":"42","text":"42(2024), Artikel-ID 73, Seite 1-7"},"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"id":{"eki":["254910874"],"issn":["1433-8726"],"zdb":["1463303-6"]},"recId":"254910874","physDesc":[{"extent":"Online-Ressource"}],"pubHistory":["1.1983 -"],"note":["Gesehen am 06.12.05","Teils ungezählte Beil.: Supplement"]}],"origin":[{"dateIssuedDisp":"07 February 2024","dateIssuedKey":"2024"}],"title":[{"subtitle":"a multicenter cohort analysis","title":"Do we need MRI in all biopsy naïve patients?","title_sort":"Do we need MRI in all biopsy naïve patients?"}]} | ||
| SRT | |a KRAUSEWITZDOWENEEDMR0720 | ||