Geriatric assessment of older patients receiving Trabectedin in first-line treatment for advanced soft tissue Sarcomas: the E-TRAB study from the German Interdisciplinary Sarcoma Group (GISG-13)
E-TRAB was a non-interventional, prospective trial investigating the feasibility and predictive value of geriatric assessments (GA) in older STS patients treated with trabectedin as first-line therapy. Primary endpoints were overall survival (OS), quality of life and individual clinical benefit asse...
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| Hauptverfasser: | , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
28 January 2024
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| In: |
Cancers
Year: 2024, Jahrgang: 16, Heft: 3, Pages: 1-17 |
| ISSN: | 2072-6694 |
| DOI: | 10.3390/cancers16030558 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/cancers16030558 Verlag, kostenfrei, Volltext: https://www.mdpi.com/2072-6694/16/3/558 
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| Verfasserangaben: | Bernd Kasper, Daniel Pink, Christian Rothermundt, Stephan Richter, Marinela Augustin, Attila Kollar, Annegret Kunitz, Wolfgang Eisterer, Verena Gaidzik, Thomas Brodowicz, Gerlinde Egerer, Peter Reichardt, Peter Hohenberger and Markus K. Schuler |
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| 245 | 1 | 0 | |a Geriatric assessment of older patients receiving Trabectedin in first-line treatment for advanced soft tissue Sarcomas |b the E-TRAB study from the German Interdisciplinary Sarcoma Group (GISG-13) |c Bernd Kasper, Daniel Pink, Christian Rothermundt, Stephan Richter, Marinela Augustin, Attila Kollar, Annegret Kunitz, Wolfgang Eisterer, Verena Gaidzik, Thomas Brodowicz, Gerlinde Egerer, Peter Reichardt, Peter Hohenberger and Markus K. Schuler |
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| 520 | |a E-TRAB was a non-interventional, prospective trial investigating the feasibility and predictive value of geriatric assessments (GA) in older STS patients treated with trabectedin as first-line therapy. Primary endpoints were overall survival (OS), quality of life and individual clinical benefit assessed by the patient-reported outcome measures QLQ-C30 and PRO-CTCAE. Further, several GA tools were applied and correlated with clinical outcomes and treatment-related toxicities. The final analyses included 69 patients from 12 German-speaking sites. The median age of patients was 78 years (range: 55 to 88). Baseline data on PROs and GA identified a diverse population of older patients with respect to their global health status, although a large proportion of them suffered from limitations, required geriatric help and had a high risk of morbidity. The Cancer and Age Research Group (CARG) score classified 38%, 29% and 23% of the patients with low, intermediate and high risks for therapy-related side effects, respectively. Median OS was 11.2 months [95%CI: 5.6; 19.4]. The study confirmed that trabectedin as first-line treatment in older patients with STS has an acceptable and manageable safety profile. Potential prognostic factors for clinical outcome and therapy-related toxicity were identified among the GA tools. Long Timed Up and Go (TUG) showed a significant correlation to OS and early death, whereas a high CARG score (>9) was associated with an increase in unplanned hospitalizations and the incidence of toxicities grade ≥ 3. | ||
| 650 | 4 | |a geriatric assessment | |
| 650 | 4 | |a patient-reported outcome | |
| 650 | 4 | |a PRO | |
| 650 | 4 | |a soft tissue sarcoma | |
| 650 | 4 | |a STS | |
| 650 | 4 | |a trabectedin | |
| 700 | 1 | |a Pink, Daniel |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rothermundt, Christian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Richter, Stephan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Augustin, Marinela |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kollar, Attila |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kunitz, Annegret |e VerfasserIn |4 aut | |
| 700 | 1 | |a Eisterer, Wolfgang |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Brodowicz, Thomas |e VerfasserIn |4 aut | |
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