Comorbidity in limited disease small-cell lung cancer: age-adjusted Charlson comorbidity index and its association with overall survival following chemoradiotherapy
Background: Combined, platinum-based thoracic chemoradiotherapy (TCR) is the current state-of-the-art treatment for patients with limited disease (LD) small-cell lung cancer (SCLC). There is only limited data available regarding the effect of comorbidities on survival following TRC. The purpose of t...
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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
24 July 2023
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| In: |
Clinical and translational radiation oncology
Year: 2023, Volume: 42, Pages: 1-7 |
| ISSN: | 2405-6308 |
| DOI: | 10.1016/j.ctro.2023.100665 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ctro.2023.100665 Verlag, lizenzpflichtig, Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410177/ 
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| Author Notes: | Christoph A. Fink, Fabian Weykamp, Sebastian Adeberg, Farastuk Bozorgmehr, Petros Christopoulos, Kristin Lang, Laila König, Juliane Hörner-Rieber, Michael Thomas, Martin Steins, Rami A. El-Shafie, Stefan Rieken, Denise Bernhardt, Jürgen Debus |
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| 245 | 1 | 0 | |a Comorbidity in limited disease small-cell lung cancer |b age-adjusted Charlson comorbidity index and its association with overall survival following chemoradiotherapy |c Christoph A. Fink, Fabian Weykamp, Sebastian Adeberg, Farastuk Bozorgmehr, Petros Christopoulos, Kristin Lang, Laila König, Juliane Hörner-Rieber, Michael Thomas, Martin Steins, Rami A. El-Shafie, Stefan Rieken, Denise Bernhardt, Jürgen Debus |
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| 520 | |a Background: Combined, platinum-based thoracic chemoradiotherapy (TCR) is the current state-of-the-art treatment for patients with limited disease (LD) small-cell lung cancer (SCLC). There is only limited data available regarding the effect of comorbidities on survival following TRC. The purpose of this study is to assess the age-adjusted Charlson comorbidity index (ACCI) as a predictor of overall survival in LD-SCLC patients undergoing TCR. Patients and methods: We retrospectively analyzed 367 SCLC patients diagnosed with LD-SCLC who received TCR between 2003 and 2017. We evaluated the ACCI (n = 348) as a predictor of overall survival (OS). In this cohort, 322 patients (88%) received platinum-based TCR (either cisplatin or carboplatin), and 37 (10%) patients received vincristine based TCR. Median radiation dose was 60 Gy (range 24–66 Gy). Additionally, 83% of patients (n = 303) received prophylactic cranial irradiation (PCI, 30 Gy in 2 Gy fractions). Kaplan–Meier survival analysis was performed for OS. For comparison of survival curves, Log-rank (Mantel-Cox) test was used. Univariate and multivariate Cox proportional-hazards ratios (HRs) were used to assess the influence of cofactors on OS. Results: Patients with an ACCI > 6 had a significantly shorter OS compared with patients with an ACCI ≤ 6 (median 11 vs. 20 months; p = 0.005). Univariate analysis for OS revealed a statistically significant effect for ACCI > 6 (HR 1.7; 95% CI 1.2–2.4; p = 0.003), PCI (HR 0.5; 95% CI 0.3–0.7; p < 0.001), and Karnofsky performance status ≤ 70% (KPS) (HR 1.4; 95% CI 1.1–1.90; p = 0.015). In multivariate analysis, OS was significantly associated with PCI (HR 0.6; 95% CI 0.4–0.9; p = 0.022) and ACCI > 6 (HR 1.5; 95% CI 1.0–2.1; p = 0.049). Conclusion: Comorbidity is significantly associated with survival in patients with LD-SCLC undergoing TCR. The ACCI may be a valuable tool to identify patients with a shorter survival and thus might be used for risk stratification and oncological decision making. Keywords: Small cell lung cancer, Survival, Limited disease, Comorbidity, Charlson comorbidity index, CCI, SCLC | ||
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