Bcl-2 antagonizes apoptotic cell death induced by two new ceramide analogues
Ceramides which arise in part from the breakdown of sphingomyelin comprise a class of antiproliferative lipids and have been implicated in the regulation of programmed cell death better known as apoptosis. In the present study, two new synthetic ceramide analogues, N-thioacetylsphingosine and FS-5,...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
July 1997
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| In: |
FEBS letters
Year: 1997, Jahrgang: 411, Heft: 2, Pages: 260-264 |
| ISSN: | 1873-3468 |
| DOI: | 10.1016/S0014-5793(97)00717-5 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0014-5793(97)00717-5 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0014579397007175 
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| Verfasserangaben: | Thomas Wieder, Christoph C. Geilen, Thomas Kolter, Farsaneh Sadeghlar, Konrad Sandhoff, Reinhard Brossmer, Petra Ihrig, David Perry, Constantin E. Orfanos, Yusuf A Hannun |
MARC
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| 520 | |a Ceramides which arise in part from the breakdown of sphingomyelin comprise a class of antiproliferative lipids and have been implicated in the regulation of programmed cell death better known as apoptosis. In the present study, two new synthetic ceramide analogues, N-thioacetylsphingosine and FS-5, were used in Molt4 cells to induce cell death. Besides their cytotoxic effects at concentrations ≥14 μM the data obtained clearly show that both analogues induced apoptosis at concentrations below this critical concentration as assessed by trypan blue exclusion and cleavage of the death substrate poly-(ADP-ribose) polymerase (PARP). Additional experiments in bcl-2-transfected Molt4 cells revealed that the apoptotic but not the lytic effects of the analogues were antagonized by the apoptosis inhibitor Bcl-2. Furthermore, neither N-thio-acetylsphingosine nor FS-5 induced PARP cleavage in bcl-2-transfected Molt4 cells indicating that the induction of apoptotic cell death by cell permeable ceramides is not due to unspecific disturbance of the cell membrane. | ||
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| 650 | 4 | |a Bcl-2 | |
| 650 | 4 | |a Sphingomyelin cycle | |
| 650 | 4 | |a Synthetic ceramide | |
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| 700 | 1 | |a Hannun, Yusuf A |e VerfasserIn |4 aut | |
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