Sex-specific association between prenatal androgenization (second-to-fourth digit length ratio) and frontal brain volumes in adolescents
Prenatal androgenization associates sex-dependently with behavior and mental health in adolescence and adulthood, including risk-taking, emotionality, substance use, and depression. However, still little is known on how it affects underlying neural correlates, like frontal brain control regions. Thu...
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| Hauptverfasser: | , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
September 2023
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| In: |
European archives of psychiatry and clinical neuroscience
Year: 2023, Jahrgang: 273, Heft: 6, Pages: 1243-1254 |
| ISSN: | 1433-8491 |
| DOI: | 10.1007/s00406-022-01515-4 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00406-022-01515-4 Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s00406-022-01515-4 
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| Verfasserangaben: | Bernd Lenz, Sarah Gerhardt, Rafat Boroumand-Jazi, Anna Eichler, Verena Nadine Buchholz, Peter A. Fasching, Johannes Kornhuber, Tobias Banaschewski, Herta Flor, Stella Guldner, Maren Prignitz, Frauke Nees, IMAC-Mind Consortium |
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| 245 | 1 | 0 | |a Sex-specific association between prenatal androgenization (second-to-fourth digit length ratio) and frontal brain volumes in adolescents |c Bernd Lenz, Sarah Gerhardt, Rafat Boroumand-Jazi, Anna Eichler, Verena Nadine Buchholz, Peter A. Fasching, Johannes Kornhuber, Tobias Banaschewski, Herta Flor, Stella Guldner, Maren Prignitz, Frauke Nees, IMAC-Mind Consortium |
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| 520 | |a Prenatal androgenization associates sex-dependently with behavior and mental health in adolescence and adulthood, including risk-taking, emotionality, substance use, and depression. However, still little is known on how it affects underlying neural correlates, like frontal brain control regions. Thus, we tested whether prenatal androgen load is sex-dependently related to frontal cortex volumes in a sex-balanced adolescent sample. In a cross-sectional magnetic resonance imaging study, we examined 61 adolescents (28 males, 33 females; aged 14 or 16 years) and analyzed associations of frontal brain region volumes with the second-to-fourth digit length ratio (2D:4D), an established marker for prenatal androgenization, using voxel-based morphometry in a region-of-interest approach. Lower 2D:4D (indicative of higher prenatal androgen load) correlated significantly with smaller volumes of the right anterior cingulate cortex (r-ACC; β = 0.45) in male adolescents and with larger volumes of the left inferior frontal gyrus orbital part (l-IFGorb; β = - 0.38) in female adolescents. The regression slopes of 2D:4D on the r-ACC also differed significantly between males and females. The study provides novel evidence that prenatal androgenization may influence the development of the frontal brain in a sex- and frontal brain region-specific manner. These effects might contribute to the well-known sex differences in risk-taking, emotionality, substance use, and depression. Future research is needed to elucidate the role of prenatal androgenization within the biopsychosocial model. | ||
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