Change in choroidal nevi during a 5-year follow-up study: the Beijing Eye Study

Background To determine the risk of growth of presumed choroidal nevi in the adult Chinese population in Greater Beijing. - Methods The Beijing Eye Study is a population-based study that was performed in 2001 and in 2006. Of 126 subjects with presumed choroidal nevi detected in 2001, 75 (60%) subjec...

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Hauptverfasser: You, Qisheng (VerfasserIn) , Xu, Liang (VerfasserIn) , Jonas, Jost B. (VerfasserIn) , Wang, Shuang (VerfasserIn) , Yang, Hua (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2010
In: British journal of ophthalmology
Year: 2010, Jahrgang: 94, Heft: 5, Pages: 575-578
ISSN:1468-2079
DOI:10.1136/bjo.2009.165720
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1136/bjo.2009.165720
Verlag, lizenzpflichtig, Volltext: https://bjo.bmj.com/content/94/5/575
Volltext
Verfasserangaben:Qi Sheng You, Liang Xu, Jost B. Jonas, Shuang Wang, Hua Yang

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520 |a Background To determine the risk of growth of presumed choroidal nevi in the adult Chinese population in Greater Beijing. - Methods The Beijing Eye Study is a population-based study that was performed in 2001 and in 2006. Of 126 subjects with presumed choroidal nevi detected in 2001, 75 (60%) subjects returned for the follow-up examination and had readable fundus photographs available. To assess any change in size or shape of the nevi, we used flicker comparison of the fundus photographs. - Results An enlargement of the presumed choroidal nevi was detected in four eyes (5.3±22.6% (mean±SD); 95% CI 0.1 to 10.5%) during the 5-year follow-up. In another four eyes (5.3±22.6%; 95% CI 0.1 to 10.5%), drusen of the retinal pigment epithelium overlying the nevi increased in size. None of the nevi regressed in size or showed clinical signs indicating a malignant transformation. The ages of the four participants with an increase in the nevus size were 43, 45, 46 and 56 years at baseline; best corrected visual acuity was 1.0 and frequency doubling perimetry results were normal. - Conclusions Only a small percentage of adult Chinese participants aged ≥40 years showed an enlargement of presumed choroidal nevi during a follow-up period of 5 years. Taking into consideration that most of the study participants were already past the age of highest risk of developing a uveal melanoma in Chinese people, the results suggest a low risk of growth of choroidal nevi into malignant choroidal melanomas in Chinese people. 
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