New results on optimal conditional error functions for adaptive two-stage designs
Unblinded interim analyses in clinical trials with adaptive designs are gaining increasing popularity. Here, the type I error rate is controlled by defining an appropriate conditional error function. Since various approaches to the selection of the conditional error function exist, the question of a...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2024
|
| In: |
Journal of applied statistics
Year: 2024, Jahrgang: 51, Heft: 15, Pages: 3178-3194 |
| ISSN: | 1360-0532 |
| DOI: | 10.1080/02664763.2024.2342424 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1080/02664763.2024.2342424
|
| Verfasserangaben: | Maximilian Pilz, Meinhard Kieser |
MARC
| LEADER | 00000caa a22000002c 4500 | ||
|---|---|---|---|
| 001 | 1894534484 | ||
| 003 | DE-627 | ||
| 005 | 20250924153957.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240708s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1080/02664763.2024.2342424 |2 doi | |
| 035 | |a (DE-627)1894534484 | ||
| 035 | |a (DE-599)KXP1894534484 | ||
| 035 | |a (OCoLC)1475301927 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Pilz, Maximilian |d 1993- |e VerfasserIn |0 (DE-588)1193938732 |0 (DE-627)1675681511 |4 aut | |
| 245 | 1 | 0 | |a New results on optimal conditional error functions for adaptive two-stage designs |c Maximilian Pilz, Meinhard Kieser |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Publikationsdatum: 17. April 2024 (Online) | ||
| 500 | |a Gesehen am 08.07.2024 | ||
| 520 | |a Unblinded interim analyses in clinical trials with adaptive designs are gaining increasing popularity. Here, the type I error rate is controlled by defining an appropriate conditional error function. Since various approaches to the selection of the conditional error function exist, the question of an optimal choice arises. In this article, we extend existing work on optimal conditional error functions by two results. Firstly, we prove that techniques from variational calculus can be applied to derive existing optimal conditional error functions. Secondly, we answer the question of optimizing the conditional error function of an optimal promising zone design and investigate the efficiency gain. | ||
| 650 | 4 | |a Adaptive design | |
| 650 | 4 | |a clinical trial | |
| 650 | 4 | |a conditional error function | |
| 650 | 4 | |a optimal design | |
| 650 | 4 | |a variational calculus | |
| 700 | 1 | |a Kieser, Meinhard |d 1960- |e VerfasserIn |0 (DE-588)103276547X |0 (DE-627)739277766 |0 (DE-576)168963825 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of applied statistics |d Abingdon [u.a.] : Taylor & Francis, Taylor & Francis Group, 1974 |g 51(2024), 15, Seite 3178-3194 |h Online-Ressource |w (DE-627)270130462 |w (DE-600)1476802-1 |w (DE-576)263252973 |x 1360-0532 |7 nnas |a New results on optimal conditional error functions for adaptive two-stage designs |
| 773 | 1 | 8 | |g volume:51 |g year:2024 |g number:15 |g pages:3178-3194 |a New results on optimal conditional error functions for adaptive two-stage designs |
| 856 | 4 | 0 | |u https://doi.org/10.1080/02664763.2024.2342424 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20240708 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 103276547X |a Kieser, Meinhard |m 103276547X:Kieser, Meinhard |d 910000 |d 911800 |e 910000PK103276547X |e 911800PK103276547X |k 0/910000/ |k 1/910000/911800/ |p 2 |y j | ||
| 999 | |a KXP-PPN1894534484 |e 4547976511 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"display":"Pilz, Maximilian","family":"Pilz","given":"Maximilian","role":"aut"},{"display":"Kieser, Meinhard","family":"Kieser","given":"Meinhard","role":"aut"}],"note":["Publikationsdatum: 17. April 2024 (Online)","Gesehen am 08.07.2024"],"title":[{"title":"New results on optimal conditional error functions for adaptive two-stage designs","title_sort":"New results on optimal conditional error functions for adaptive two-stage designs"}],"origin":[{"dateIssuedDisp":"2024","dateIssuedKey":"2024"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"name":{"displayForm":["Maximilian Pilz, Meinhard Kieser"]},"recId":"1894534484","relHost":[{"id":{"eki":["270130462"],"issn":["1360-0532"],"zdb":["1476802-1"]},"physDesc":[{"extent":"Online-Ressource"}],"recId":"270130462","pubHistory":["1.1974 -"],"part":{"volume":"51","pages":"3178-3194","text":"51(2024), 15, Seite 3178-3194","issue":"15","year":"2024"},"origin":[{"publisher":"Taylor & Francis, Taylor & Francis Group ; Carfax ; Routledge","dateIssuedKey":"1974","publisherPlace":"Abingdon [u.a.] ; Basingstoke [u.a.] ; London [u.a.]","dateIssuedDisp":"1974-"}],"note":["Gesehen am 13.03.15"],"title":[{"title":"Journal of applied statistics","title_sort":"Journal of applied statistics"}],"titleAlt":[{"title":"Bulletin in applied statistics"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"language":["eng"],"disp":"New results on optimal conditional error functions for adaptive two-stage designsJournal of applied statistics"}],"id":{"eki":["1894534484"],"doi":["10.1080/02664763.2024.2342424"]}} | ||
| SRT | |a PILZMAXIMINEWRESULTS2024 | ||