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Association of lipid-lowering drugs and antidiabetic drugs with age-related macular degeneration: a meta-analysis in Europeans : clinical science

Background/aims To investigate the association of commonly used systemic medications with prevalent age-related macular degeneration (AMD) in the general population. - Methods We included 38 694 adults from 14 population-based and hospital-based studies from the European Eye Epidemiology consortium....

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Main Authors: Mauschitz, Matthias (Author) , Verzijden, Timo (Author) , Schuster, Alexander K. (Author) , Elbaz, Hisham (Author) , Pfeiffer, Norbert (Author) , Khawaja, Anthony (Author) , Luben, Robert N. (Author) , Foster, Paul J. (Author) , Rauscher, Franziska G. (Author) , Wirkner, Kerstin (Author) , Kirsten, Toralf (Author) , Jonas, Jost B. (Author) , Bikbov, Mukharram M. (Author) , Hogg, Ruth (Author) , Peto, Tunde (Author) , Cougnard-Grégoire, Audrey (Author) , Bertelsen, Geir (Author) , Erke, Maja Gran (Author) , Topouzis, Fotis (Author) , Giannoulis, Dimitrios A. (Author) , Brandl, Caroline (Author) , Heid, Iris M. (Author) , Creuzot-Garcher, Catherine P. (Author) , Gabrielle, Pierre-Henry (Author) , Hense, Hans-Werner (Author) , Pauleikhoff, Daniel (Author) , Barreto, Patricia (Author) , Coimbra, Rita (Author) , Piermarocchi, Stefano (Author) , Daien, Vincent (Author) , Holz, Frank G. (Author) , Delcourt, Cecile (Author) , Finger, Robert P. (Author)
Format: Article (Journal)
Language:English
Published: November 22, 2023
In: British journal of ophthalmology
Year: 2023, Volume: 107, Issue: 12, Pages: 1880-1886
ISSN:1468-2079
DOI:10.1136/bjo-2022-321985
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1136/bjo-2022-321985
Verlag, lizenzpflichtig, Volltext: http://bjo.bmj.com/content/107/12/1880
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Author Notes:Matthias M. Mauschitz, Timo Verzijden, Alexander K. Schuster, Hisham Elbaz, Norbert Pfeiffer, Anthony Khawaja, Robert N. Luben, Paul J. Foster, Franziska G. Rauscher, Kerstin Wirkner, Toralf Kirsten, Jost B. Jonas, Mukharram M. Bikbov, Ruth Hogg, Tunde Peto, Audrey Cougnard-Grégoire, Geir Bertelsen, Maja Gran Erke, Fotis Topouzis, Dimitrios A. Giannoulis, Caroline Brandl, Iris M. Heid, Catherine P. Creuzot-Garcher, Pierre-Henry Gabrielle, Hans-Werner Hense, Daniel Pauleikhoff, Patricia Barreto, Rita Coimbra, Stefano Piermarocchi, Vincent Daien, Frank G. Holz, Cecile Delcourt, Robert P. Finger, on behalf of the European Eye Epidemiology (E3) Consortium

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520 |a Background/aims To investigate the association of commonly used systemic medications with prevalent age-related macular degeneration (AMD) in the general population. - Methods We included 38 694 adults from 14 population-based and hospital-based studies from the European Eye Epidemiology consortium. We examined associations between the use of systemic medications and any prevalent AMD as well as any late AMD using multivariable logistic regression modelling per study and pooled results using random effects meta-analysis. - Results Between studies, mean age ranged from 61.5±7.1 to 82.6±3.8 years and prevalence ranged from 12.1% to 64.5% and from 0.5% to 35.5% for any and late AMD, respectively. In the meta-analysis of fully adjusted multivariable models, lipid-lowering drugs (LLD) and antidiabetic drugs were associated with lower prevalent any AMD (OR 0.85, 95% CI=0.79 to 0.91 and OR 0.78, 95% CI=0.66 to 0.91). We found no association with late AMD or with any other medication. - Conclusion Our study indicates a potential beneficial effect of LLD and antidiabetic drug use on prevalence of AMD across multiple European cohorts. Our findings support the importance of metabolic processes in the multifactorial aetiology of AMD. 
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