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Sex-specific differences in ICOS+ T helper cell differentiation in systemic lupus erythematosus patients with low disease activity

Systemic lupus erythematosus (SLE) is a sex biased chronic autoimmune disease affecting predominantly females during reproductive ages. Changes in the ratio of inducible costimulatory molecule (ICOS)+ regulatory (Treg) and non-regulatory responder (Tresp) CD4+ T cells proved to be crucial for the oc...

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Hauptverfasser: Wu, Lisa (VerfasserIn) , Kälble, Florian (VerfasserIn) , Lorenz, Hanns-Martin (VerfasserIn) , Zeier, Martin (VerfasserIn) , Schaier, Matthias (VerfasserIn) , Steinborn-Kröhl, Andrea (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 01 March 2024
In: Clinical and experimental medicine
Year: 2024, Jahrgang: 24, Pages: 1-13
ISSN:1591-9528
DOI:10.1007/s10238-024-01307-1
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s10238-024-01307-1
Volltext
Verfasserangaben:Lisa Wu, Florian Kälble, Hanns-Martin Lorenz, Martin Zeier, Matthias Schaier, Andrea Steinborn
Beschreibung
Zusammenfassung:Systemic lupus erythematosus (SLE) is a sex biased chronic autoimmune disease affecting predominantly females during reproductive ages. Changes in the ratio of inducible costimulatory molecule (ICOS)+ regulatory (Treg) and non-regulatory responder (Tresp) CD4+ T cells proved to be crucial for the occurrence of high disease activity. Here, we investigated how the differentiation of ICOS+CD45RA+CD31+ recent thymic emigrant (RTE) Tresps into CD45RA−CD31− memory Tresps affects the percentages of ICOS+ Tresps within total CD4+ T cells. Three different pathways (pathway 1 via CD45RA−CD31+ memory Tresps, pathway 2 via direct proliferation and pathway 3 via resting mature naïve CD45RA+CD31− (MN) cells) were examined in healthy controls and SLE remission patients separated by sex. In female SLE remission patients, immunosuppressive therapy inhibited the ICOS+ RTE differentiation via CD45RA−CD31+ memory Tresps and direct proliferation, leaving an age-independently increased differentiation into CD45RA−CD31− memory Tresps by conversion of resting MN Tresps compared with healthy controls. Due to exhaustion of this pathway with age, no age-dependent change in the percentages of ICOS+ Tresps within total CD4+ T cells could be found. In contrast, no age-independently increased differentiation could be detected in men due to sufficient immunosuppression of all three pathways. This allowed an age-dependent differentiation of ICOS+ RTE Tresps into CD45RA−CD31− memory Tresps by conversion of resting MN Tresps, resulting in age-dependently increasing percentages of ICOS+ Tresps within total CD4+ T cells. We hypothesize that the sex-specific differential effect of immunosuppression on the differentiation of ICOS+ Tresps may explain the sex- and age-dependent occurrence of high disease activity.
Beschreibung:Online veröffentlicht: 01. März 2024
Gesehen am 11.07.2024
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Beschreibung:Online Resource
ISSN:1591-9528
DOI:10.1007/s10238-024-01307-1

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