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Likelihood of post-COVID condition in people with hybrid immunity: data from the German National Cohort (NAKO)

Objectives - The risk of Post-COVID-19 condition (PCC) under hybrid immunity remains unclear. - Methods - Using data from the German National Cohort (NAKO Gesundheitsstudie), we investigated risk factors for self-reported post-infection symptoms (any PCC is defined as having at least one symptom, an...

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Main Authors: Mikolajczyk, Rafael (Author) , Diexer, Sophie (Author) , Klee, Bianca (Author) , Pfrommer, Laura (Author) , Purschke, Oliver (Author) , Fricke, Julia (Author) , Ahnert, Peter (Author) , Gabrysch, Sabine (Author) , Gottschick, Cornelia (Author) , Bohn, Barbara (Author) , Brenner, Hermann (Author) , Buck, Christoph (Author) , Castell, Stefanie (Author) , Gastell, Sylvia (Author) , Greiser, Karin Halina (Author) , Harth, Volker (Author) , Heise, Jana-Kristin (Author) , Holleczek, Bernd (Author) , Kaaks, Rudolf (Author) , Keil, Thomas (Author) , Krist, Lilian (Author) , Leitzmann, Michael (Author) , Lieb, Wolfgang (Author) , Meinke-Franze, Claudia (Author) , Michels, Karin (Author) , Velásquez, Ilais Moreno (Author) , Obi, Nadia (Author) , Panreck, Leo (Author) , Peters, Annette (Author) , Pischon, Tobias (Author) , Schikowski, Tamara (Author) , Schmidt, Börge (Author) , Standl, Marie (Author) , Stang, Andreas (Author) , Völzke, Henry (Author) , Weber, Andrea (Author) , Zeeb, Hajo (Author) , Karch, André (Author)
Format: Article (Journal)
Language:English
Published: August 2024
In: Journal of infection
Year: 2024, Volume: 89, Issue: 2, Pages: 1-7
ISSN:1532-2742
DOI:10.1016/j.jinf.2024.106206
Online Access:Resolving-System, kostenfrei, Volltext: https://doi.org/10.1016/j.jinf.2024.106206
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S0163445324001403
Resolving-System, kostenfrei: https://doi.org/10.25673/118268
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Author Notes:Rafael Mikolajczyk, Sophie Diexer, Bianca Klee, Laura Pfrommer, Oliver Purschke, Julia Fricke, Peter Ahnert, Sabine Gabrysch, Cornelia Gottschick, Barbara Bohn, Hermann Brenner, Christoph Buck, Stefanie Castell, Sylvia Gastell, Karin Halina Greiser, Volker Harth, Jana-Kristin Heise, Bernd Holleczek, Rudolf Kaaks, Thomas Keil, Lilian Krist, Michael Leitzmann, Wolfgang Lieb, Claudia Meinke-Franze, Karin B. Michels, Ilais Moreno Velásquez, Nadia Obi, Leo Panreck, Annette Peters, Tobias Pischon, Tamara Schikowski, Börge Schmidt, Marie Standl, Andreas Stang, Henry Völzke, Andrea Weber, Hajo Zeeb, André Karch
Description
Summary:Objectives - The risk of Post-COVID-19 condition (PCC) under hybrid immunity remains unclear. - Methods - Using data from the German National Cohort (NAKO Gesundheitsstudie), we investigated risk factors for self-reported post-infection symptoms (any PCC is defined as having at least one symptom, and high symptom burden PCC as having nine or more symptoms). - Results - Sixty percent of 109,707 participants reported at least one previous SARS-CoV-2 infection; 35% reported having had any symptoms 4-12 months after infection; among them 23% reported nine or more symptoms. Individuals, who did not develop PCC after their first infection, had a strongly reduced risk for PCC after their second infection (50%) and a temporary risk reduction, which waned over 9 months after the preceding infection. The risk of developing PCC strongly depended on the virus variant. Within variants, there was no effect of the number of preceding vaccinations, apart from a strong protection by the fourth vaccination compared to three vaccinations for the Omicron variant (odds ratio = 0.52; 95% confidence interval 0.45-0.61). - Conclusions - Previous infections without PCC and a fourth vaccination were associated with a lower risk of PCC after a new infection, indicating diminished risk under hybrid immunity. The two components of risk reduction after a preceding infection suggest different immunological mechanisms.
Physical Description:Online Resource
ISSN:1532-2742
DOI:10.1016/j.jinf.2024.106206

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