Cost-effectiveness of opportunistic QCT-based osteoporosis screening for the prediction of incident vertebral fractures
Objectives: Opportunistic quantitative computed tomography (oQCT) derived from non-dedicated routine CT has demonstrated high accuracy in diagnosing osteoporosis and predicting incident vertebral fractures (VFs). We aimed to investigate the cost-effectiveness of oQCT screening compared to dual-energ...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
31 July 2023
|
| In: |
Frontiers in endocrinology
Year: 2023, Volume: 14, Pages: 1-11 |
| ISSN: | 1664-2392 |
| DOI: | 10.3389/fendo.2023.1222041 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3389/fendo.2023.1222041 Verlag, lizenzpflichtig, Volltext: https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1222041/full 
|
| Author Notes: | Sebastian Rühling, Julian Schwarting, Matthias F. Froelich, Maximilian T. Löffler, Jannis Bodden, Moritz R. Hernandez Petzsche, Thomas Baum, Maria Wostrack, A. Kaywan Aftahy, Vanadin Seifert-Klauss, Nico Sollmann, Claus Zimmer, Jan S. Kirschke and Fabian Tollens |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1895400937 | ||
| 003 | DE-627 | ||
| 005 | 20250118002101.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240715s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3389/fendo.2023.1222041 |2 doi | |
| 035 | |a (DE-627)1895400937 | ||
| 035 | |a (DE-599)KXP1895400937 | ||
| 035 | |a (OCoLC)1475302648 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Rühling, Sebastian |d 1992- |e VerfasserIn |0 (DE-588)1248317920 |0 (DE-627)1783542152 |4 aut | |
| 245 | 1 | 0 | |a Cost-effectiveness of opportunistic QCT-based osteoporosis screening for the prediction of incident vertebral fractures |c Sebastian Rühling, Julian Schwarting, Matthias F. Froelich, Maximilian T. Löffler, Jannis Bodden, Moritz R. Hernandez Petzsche, Thomas Baum, Maria Wostrack, A. Kaywan Aftahy, Vanadin Seifert-Klauss, Nico Sollmann, Claus Zimmer, Jan S. Kirschke and Fabian Tollens |
| 264 | 1 | |c 31 July 2023 | |
| 300 | |b Illustrationen | ||
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 15.07.2024 | ||
| 520 | |a Objectives: Opportunistic quantitative computed tomography (oQCT) derived from non-dedicated routine CT has demonstrated high accuracy in diagnosing osteoporosis and predicting incident vertebral fractures (VFs). We aimed to investigate the cost-effectiveness of oQCT screening compared to dual-energy X-ray absorptiometry (DXA) as the standard of care for osteoporosis screening. Methods: Three screening strategies (“no osteoporosis screening”, “oQCT screening”, and “DXA screening”) after routine CT were simulated in a state-transition model for hypothetical cohorts of 1,000 patients (women and men aged 65 years) over a follow-up period of 5 years (base case). The primary outcomes were the cumulative costs and the quality-adjusted life years (QALYs) estimated from a U.S. health care perspective for the year 2022. Cost-effectiveness was assessed based on a willingness-to-pay (WTP) threshold of $70,249 per QALY. The secondary outcome was the number of prevented VFs. Deterministic and probabilistic sensitivity analyses were conducted to test the models’ robustness. Results: Compared to DXA screening, oQCT screening increased QALYs in both sexes (additional 2.40 per 1,000 women and 1.44 per 1,000 men) and resulted in total costs of $3,199,016 and $950,359 vs. $3,262,934 and $933,077 for women and men, respectively. As a secondary outcome, oQCT screening prevented 2.6 and 2.0 additional VFs per 1,000 women and men, respectively. In the probabilistic sensitivity analysis, oQCT screening remained cost-effective in 88.3% (women) and 90.0% (men) of iterations. Conclusion: oQCT screening is a cost-effective ancillary approach for osteoporosis screening and has the potential to prevent a substantial number of VFs if considered in daily clinical practice. | ||
| 650 | 4 | |a cost-effectiveness analysis | |
| 650 | 4 | |a fracture prevention | |
| 650 | 4 | |a opportunistic QCT | |
| 650 | 4 | |a Osteoporosis | |
| 650 | 4 | |a screening | |
| 700 | 1 | |8 1\p |a Schwarting, Julian |d 1991- |e VerfasserIn |0 (DE-588)1218247304 |0 (DE-627)1733676929 |4 aut | |
| 700 | 1 | |a Froelich, Matthias F. |d 1991- |e VerfasserIn |0 (DE-588)1170833756 |0 (DE-627)1040131557 |0 (DE-576)512678359 |4 aut | |
| 700 | 1 | |a Löffler, Maximilian T. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bodden, Jannis |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hernandez Petzsche, Moritz R. |e VerfasserIn |4 aut | |
| 700 | 1 | |8 2\p |a Baum, Thomas |d 1981- |e VerfasserIn |0 (DE-588)143644815 |0 (DE-627)653832060 |0 (DE-576)338149449 |4 aut | |
| 700 | 1 | |8 3\p |a Wostrack, Maria |d 1981- |e VerfasserIn |0 (DE-588)141367539 |0 (DE-627)629423970 |0 (DE-576)32413486X |4 aut | |
| 700 | 1 | |a Aftahy, A. Kaywan |e VerfasserIn |4 aut | |
| 700 | 1 | |8 4\p |a Seifert-Klauss, Vanadin |d 1963- |e VerfasserIn |0 (DE-588)114234310 |0 (DE-627)691211396 |0 (DE-576)28979045X |4 aut | |
| 700 | 1 | |a Sollmann, Nico |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zimmer, Claus |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kirschke, Jan |e VerfasserIn |0 (DE-588)1261127110 |0 (DE-627)1883296323 |4 aut | |
| 700 | 1 | |a Tollens, Fabian |d 1993- |e VerfasserIn |0 (DE-588)1158694911 |0 (DE-627)1020771615 |0 (DE-576)504310925 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Frontiers in endocrinology |d Lausanne : Frontiers Research Foundation, 2010 |g 14(2023), Seite 1-11 |h Online-Ressource |w (DE-627)645090948 |w (DE-600)2592084-4 |w (DE-576)336962975 |x 1664-2392 |7 nnas |a Cost-effectiveness of opportunistic QCT-based osteoporosis screening for the prediction of incident vertebral fractures |
| 773 | 1 | 8 | |g volume:14 |g year:2023 |g pages:1-11 |g extent:11 |a Cost-effectiveness of opportunistic QCT-based osteoporosis screening for the prediction of incident vertebral fractures |
| 856 | 4 | 0 | |u https://doi.org/10.3389/fendo.2023.1222041 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1222041/full |x Verlag |z lizenzpflichtig |3 Volltext |
| 883 | |8 1\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 2\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 3\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 4\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 951 | |a AR | ||
| 992 | |a 20240715 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 1158694911 |a Tollens, Fabian |m 1158694911:Tollens, Fabian |d 60000 |d 62900 |e 60000PT1158694911 |e 62900PT1158694911 |k 0/60000/ |k 1/60000/62900/ |p 14 |y j | ||
| 998 | |g 1170833756 |a Froelich, Matthias F. |m 1170833756:Froelich, Matthias F. |d 60000 |d 62900 |d 60000 |e 60000PF1170833756 |e 62900PF1170833756 |e 60000PF1170833756 |k 0/60000/ |k 1/60000/62900/ |k 0/60000/ |p 3 | ||
| 999 | |a KXP-PPN1895400937 |e 4551055492 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title":"Cost-effectiveness of opportunistic QCT-based osteoporosis screening for the prediction of incident vertebral fractures","title_sort":"Cost-effectiveness of opportunistic QCT-based osteoporosis screening for the prediction of incident vertebral fractures"}],"note":["Gesehen am 15.07.2024"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"relHost":[{"disp":"Cost-effectiveness of opportunistic QCT-based osteoporosis screening for the prediction of incident vertebral fracturesFrontiers in endocrinology","physDesc":[{"extent":"Online-Ressource"}],"recId":"645090948","note":["Gesehen am 12.12.19","Specialty sections: Bone Research; Cancer Endocrinology; Cellular Endocrinology; Diabetes; Endocrinology of Aging; Experimental Endocrinology; Genomic Endocrinology; Molecular and Structural Endocrinology; Neuroendocrine Science; Pediatric Endocrinology; Pituitary Endocrinology; Systems and Translational Endocrinology; Thyroid Endocrinology"],"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"title":[{"title":"Frontiers in endocrinology","title_sort":"Frontiers in endocrinology"}],"origin":[{"publisher":"Frontiers Research Foundation","dateIssuedDisp":"2010-","dateIssuedKey":"2010","publisherPlace":"Lausanne"}],"part":{"extent":"11","text":"14(2023), Seite 1-11","volume":"14","year":"2023","pages":"1-11"},"id":{"eki":["645090948"],"issn":["1664-2392"],"zdb":["2592084-4"]},"pubHistory":["1.2010 -"],"titleAlt":[{"title":"Bone Research"},{"title":"Cancer Endocrinology"},{"title":"Cellular Endocrinology"},{"title":"Diabetes"},{"title":"Endocrinology of Aging"},{"title":"Experimental Endocrinology"},{"title":"Genomic Endocrinology"},{"title":"Molecular and Structural Endocrinology"},{"title":"Neuroendocrine Science"},{"title":"Pediatric Endocrinology"},{"title":"Pituitary Endocrinology"},{"title":"Systems and Translational Endocrinology"},{"title":"Thyroid Endocrinology"}]}],"person":[{"display":"Rühling, Sebastian","given":"Sebastian","role":"aut","family":"Rühling"},{"given":"Julian","role":"aut","family":"Schwarting","display":"Schwarting, Julian"},{"family":"Froelich","role":"aut","given":"Matthias F.","display":"Froelich, Matthias F."},{"display":"Löffler, Maximilian T.","role":"aut","given":"Maximilian T.","family":"Löffler"},{"display":"Bodden, Jannis","family":"Bodden","given":"Jannis","role":"aut"},{"given":"Moritz R.","role":"aut","family":"Hernandez Petzsche","display":"Hernandez Petzsche, Moritz R."},{"given":"Thomas","role":"aut","family":"Baum","display":"Baum, Thomas"},{"display":"Wostrack, Maria","family":"Wostrack","given":"Maria","role":"aut"},{"display":"Aftahy, A. Kaywan","family":"Aftahy","given":"A. Kaywan","role":"aut"},{"display":"Seifert-Klauss, Vanadin","family":"Seifert-Klauss","given":"Vanadin","role":"aut"},{"display":"Sollmann, Nico","family":"Sollmann","role":"aut","given":"Nico"},{"display":"Zimmer, Claus","given":"Claus","role":"aut","family":"Zimmer"},{"display":"Kirschke, Jan","role":"aut","given":"Jan","family":"Kirschke"},{"display":"Tollens, Fabian","family":"Tollens","role":"aut","given":"Fabian"}],"origin":[{"dateIssuedDisp":"31 July 2023","dateIssuedKey":"2023"}],"recId":"1895400937","physDesc":[{"noteIll":"Illustrationen","extent":"11 S."}],"id":{"doi":["10.3389/fendo.2023.1222041"],"eki":["1895400937"]},"name":{"displayForm":["Sebastian Rühling, Julian Schwarting, Matthias F. Froelich, Maximilian T. Löffler, Jannis Bodden, Moritz R. Hernandez Petzsche, Thomas Baum, Maria Wostrack, A. Kaywan Aftahy, Vanadin Seifert-Klauss, Nico Sollmann, Claus Zimmer, Jan S. Kirschke and Fabian Tollens"]}} | ||
| SRT | |a RUEHLINGSECOSTEFFECT3120 | ||