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External validation of yonsei nomogram predicting chronic kidney disease development after partial nephrectomy: an international, multicenter study : clinical investigation

Objective To externally validate Yonsei nomogram. Methods From 2000 through 2018, 3526 consecutive patients underwent on-clamp PN for cT1 renal masses at 23 centers were included. All patients had two kidneys, preoperative eGFR ≥60 ml/min/1.73 m2, and a minimum follow-up of 12 months. New-onset CKD...

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Main Authors: Abdel Raheem, Ali (Author) , Landi, Isotta (Author) , Alowidah, Ibrahim (Author) , Capitanio, Umberto (Author) , Montorsi, Francesco (Author) , Larcher, Alessandro (Author) , Derweesh, Ithaar (Author) , Ghali, Fady (Author) , Mottrie, Alexander (Author) , Mazzone, Elio (Author) , De Naeyer, Geert (Author) , Campi, Riccardo (Author) , Sessa, Francesco (Author) , Carini, Marco (Author) , Minervini, Andrea (Author) , Raman, Jay D. (Author) , Rjepaj, Chris J. (Author) , Kriegmair, Maximilian (Author) , Autorino, Riccardo (Author) , Veccia, Alessandro (Author) , Mir, Maria Carmen (Author) , Claps, Francesco (Author) , Choi, Young Deuk (Author) , Ham, Won Sik (Author) , Santok, Glen Denmer (Author) , Tadifa, John Paul (Author) , Syling, Justin (Author) , Furlan, Maria (Author) , Simeone, Claudio (Author) , Bada, Maida (Author) , Celia, Antonio (Author) , Carrión, Diego M. (Author) , Aguilera Bazan, Alfredo (Author) , Ruiz, Cristina Ballesteros (Author) , Malki, Manar (Author) , Barber, Neil (Author) , Hussain, Muddassar (Author) , Micali, Salvatore (Author) , Puliatti, Stefano (Author) , Ghaith, Ahmed (Author) , Hagras, Ayman (Author) , Ghoneem, Ayman M. (Author) , Eissa, Ahmed (Author) , Alqahtani, Abdulrahman (Author) , Rumaih, Abdullah (Author) , Alwahabi, Abdelaziz (Author) , Alenzi, Mohammed Jayed (Author) , Pavan, Nicola (Author) , Traunero, Fabio (Author) , Antonelli, Alessandro (Author) , Porcaro, Antonio Benito (Author) , Illiano, Ester (Author) , Costantini, Elisabetta (Author) , Rha, Koon Ho (Author)
Format: Article (Journal)
Language:English
Published: March 2023
In: International journal of urology
Year: 2023, Volume: 30, Issue: 3, Pages: 308-317
ISSN:1442-2042
DOI:10.1111/iju.15108
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/iju.15108
Verlag, lizenzpflichtig, Volltext: http://onlinelibrary.wiley.com/doi/abs/10.1111/iju.15108
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Author Notes:Ali Abdel Raheem, Isotta Landi, Ibrahim Alowidah, Umberto Capitanio, Francesco Montorsi, Alessandro Larcher, Ithaar Derweesh, Fady Ghali, Alexander Mottrie, Elio Mazzone, Geert De Naeyer, Riccardo Campi, Francesco Sessa, Marco Carini, Andrea Minervini, Jay D. Raman, Chris J. Rjepaj, Maximilian C. Kriegmair, Riccardo Autorino, Alessandro Veccia, Maria Carmen Mir, Francesco Claps, Young Deuk Choi, Won Sik Ham, Glen Denmer Santok, John Paul Tadifa, Justin Syling, Maria Furlan, Claudio Simeone, Maida Bada, Antonio Celia, Diego M. Carrión, Alfredo Aguilera Bazan, Cristina Ballesteros Ruiz, Manar Malki, Neil Barber, Muddassar Hussain, Salvatore Micali, Stefano Puliatti, Ahmed Ghaith, Ayman Hagras, Ayman M. Ghoneem, Ahmed Eissa, Abdulrahman Alqahtani, Abdullah Rumaih, Abdelaziz Alwahabi, Mohammed Jayed Alenzi, Nicola Pavan, Fabio Traunero, Alessandro Antonelli, Antonio Benito Porcaro, Ester Illiano, Elisabetta Costantini and Koon Ho Rha
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Summary:Objective To externally validate Yonsei nomogram. Methods From 2000 through 2018, 3526 consecutive patients underwent on-clamp PN for cT1 renal masses at 23 centers were included. All patients had two kidneys, preoperative eGFR ≥60 ml/min/1.73 m2, and a minimum follow-up of 12 months. New-onset CKD was defined as upgrading from CKD stage I or II into CKD stage ≥III. We obtained the CKD-free progression probabilities at 1, 3, 5, and 10 years for all patients by applying the nomogram found at https://eservices.ksmc.med.sa/ckd/. Thereafter, external validation of Yonsei nomogram for estimating new-onset CKD stage ≥III was assessed by calibration and discrimination analysis. Results and limitation Median values of patients' age, tumor size, eGFR and follow-up period were 47 years (IQR: 47-62), 3.3 cm (IQR: 2.5-4.2), 90.5 ml/min/1.73 m2 (IQR: 82.8-98), and 47 months (IQR: 27-65), respectively. A total of 683 patients (19.4%) developed new-onset CKD. The 5-year CKD-free progression rate was 77.9%. Yonsei nomogram demonstrated an AUC of 0.69, 0.72, 0.77, and 0.78 for the prediction of CKD stage ≥III at 1, 3, 5, and 10 years, respectively. The calibration plots at 1, 3, 5, and 10 years showed that the model was well calibrated with calibration slope values of 0.77, 0.83, 0.76, and 0.75, respectively. Retrospective database collection is a limitation of our study. Conclusions The largest external validation of Yonsei nomogram showed good calibration properties. The nomogram can provide an accurate estimate of the individual risk of CKD-free progression on long-term follow-up.
Item Description:Online veröffentlicht: 7. Dezember 2022
Gesehen am 16.07.2024
Physical Description:Online Resource
ISSN:1442-2042
DOI:10.1111/iju.15108

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