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Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants: letter

The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry genome-wide association study of 156,319 prostate cancer cases and 788,443 controls...

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Main Authors: Wang, Anqi (Author) , Brenner, Hermann (Author) , Chen, Xuechen (Author)
Format: Article (Journal) Editorial
Language:English
Published: 09 November 2023
In: Nature genetics
Year: 2023, Volume: 55, Issue: 12, Pages: 2065-2074
ISSN:1546-1718
DOI:10.1038/s41588-023-01534-4
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41588-023-01534-4
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41588-023-01534-4
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Author Notes:Anqi Wang, Hermann Brenner, Xuechen Chen [und 288 weitere]

MARC

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520 |a The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry genome-wide association study of 156,319 prostate cancer cases and 788,443 controls of European, African, Asian and Hispanic men, reflecting a 57% increase in the number of non-European cases over previous prostate cancer genome-wide association studies. We identified 187 novel risk variants for prostate cancer, increasing the total number of risk variants to 451. An externally replicated multi-ancestry GRS was associated with risk that ranged from 1.8 (per standard deviation) in African ancestry men to 2.2 in European ancestry men. The GRS was associated with a greater risk of aggressive versus non-aggressive disease in men of African ancestry (P = 0.03). Our study presents novel prostate cancer susceptibility loci and a GRS with effective risk stratification across ancestry groups. 
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