Genetic predisposition to coronary artery disease in type 2 diabetes mellitus
Background: - Coronary artery disease (CAD) is accelerated in subjects with type 2 diabetes mellitus (T2D). - Methods: - To test whether this reflects differential genetic influences on CAD risk in subjects with T2D, we performed a systematic assessment of genetic overlap between CAD and T2D in 66 6...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
December 2020
|
| In: |
Circulation. Genomic and precision medicine
Year: 2020, Jahrgang: 13, Heft: 6, Pages: 640-648 |
| ISSN: | 2574-8300 |
| DOI: | 10.1161/CIRCGEN.119.002769 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1161/CIRCGEN.119.002769 Verlag, kostenfrei, Volltext: https://www.ahajournals.org/doi/10.1161/CIRCGEN.119.002769 
|
| Verfasserangaben: | Natalie R. van Zuydam, Claes Ladenvall, Benjamin F. Voight, Rona J. Strawbridge, Juan Fernandez-Tajes, N. William Rayner, Neil R. Robertson, Anubha Mahajan, Efthymia Vlachopoulou, Anuj Goel, Marcus E. Kleber, Christopher P. Nelson, Lydia Coulter Kwee, Tõnu Esko, Evelin Mihailov, Reedik Mägi, Lili Milani, Krista Fischer, Stavroula Kanoni, Jitender Kumar, Ci Song, Jaana A. Hartiala, Nancy L. Pedersen, Markus Perola, Christian Gieger, Annette Peters, Liming Qu, Sara M. Willems, Alex S.F. Doney, Andrew D. Morris, Yan Zheng, Giorgio Sesti, Frank B. Hu, Lu Qi, Markku Laakso, Unnur Thorsteinsdottir, Harald Grallert, Cornelia van Duijn, Muredach P. Reilly, Erik Ingelsson, Panos Deloukas, Sek Kathiresan, Andres Metspalu, Svati H. Shah, Juha Sinisalo, Veikko Salomaa, Anders Hamsten, Nilesh J. Samani, Winfried März, Stanley L. Hazen, Hugh Watkins, Danish Saleheen, Andrew P. Morris, Helen M. Colhoun, Leif Groop, Mark I. McCarthy, Colin N.A. Palmer, SUMMIT Steering Committee; CARDIOGRAMplusC4D Steering Committee |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1895762642 | ||
| 003 | DE-627 | ||
| 005 | 20241205153159.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240718s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1161/CIRCGEN.119.002769 |2 doi | |
| 035 | |a (DE-627)1895762642 | ||
| 035 | |a (DE-599)KXP1895762642 | ||
| 035 | |a (OCoLC)1475303395 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Zuydam, Natalie van |e VerfasserIn |0 (DE-588)1336147172 |0 (DE-627)1895762162 |4 aut | |
| 245 | 1 | 0 | |a Genetic predisposition to coronary artery disease in type 2 diabetes mellitus |c Natalie R. van Zuydam, Claes Ladenvall, Benjamin F. Voight, Rona J. Strawbridge, Juan Fernandez-Tajes, N. William Rayner, Neil R. Robertson, Anubha Mahajan, Efthymia Vlachopoulou, Anuj Goel, Marcus E. Kleber, Christopher P. Nelson, Lydia Coulter Kwee, Tõnu Esko, Evelin Mihailov, Reedik Mägi, Lili Milani, Krista Fischer, Stavroula Kanoni, Jitender Kumar, Ci Song, Jaana A. Hartiala, Nancy L. Pedersen, Markus Perola, Christian Gieger, Annette Peters, Liming Qu, Sara M. Willems, Alex S.F. Doney, Andrew D. Morris, Yan Zheng, Giorgio Sesti, Frank B. Hu, Lu Qi, Markku Laakso, Unnur Thorsteinsdottir, Harald Grallert, Cornelia van Duijn, Muredach P. Reilly, Erik Ingelsson, Panos Deloukas, Sek Kathiresan, Andres Metspalu, Svati H. Shah, Juha Sinisalo, Veikko Salomaa, Anders Hamsten, Nilesh J. Samani, Winfried März, Stanley L. Hazen, Hugh Watkins, Danish Saleheen, Andrew P. Morris, Helen M. Colhoun, Leif Groop, Mark I. McCarthy, Colin N.A. Palmer, SUMMIT Steering Committee; CARDIOGRAMplusC4D Steering Committee |
| 246 | 3 | 0 | |a two |
| 264 | 1 | |c December 2020 | |
| 300 | |b Illustrationen | ||
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 18.07.2024 | ||
| 520 | |a Background: - Coronary artery disease (CAD) is accelerated in subjects with type 2 diabetes mellitus (T2D). - Methods: - To test whether this reflects differential genetic influences on CAD risk in subjects with T2D, we performed a systematic assessment of genetic overlap between CAD and T2D in 66 643 subjects (27 708 with CAD and 24 259 with T2D). Variants showing apparent association with CAD in stratified analyses or evidence of interaction were evaluated in a further 117 787 subjects (16 694 with CAD and 11 537 with T2D). - Results: - None of the previously characterized CAD loci was found to have specific effects on CAD in T2D individuals, and a genome-wide interaction analysis found no new variants for CAD that could be considered T2D specific. When we considered the overall genetic correlations between CAD and its risk factors, we found no substantial differences in these relationships by T2D background. - Conclusions: - This study found no evidence that the genetic architecture of CAD differs in those with T2D compared with those without T2D. | ||
| 700 | 1 | |a Ladenvall, Claes |e VerfasserIn |4 aut | |
| 700 | 1 | |a Voight, Benjamin F. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Strawbridge, Rona J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fernandez-Tajes, Juan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rayner, N. William |e VerfasserIn |4 aut | |
| 700 | 1 | |a Robertson, Neil R. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mahajan, Anubha |e VerfasserIn |4 aut | |
| 700 | 1 | |a Vlachopoulou, Efthymia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Goel, Anuj |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kleber, Marcus E. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nelson, Christopher P. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kwee, Lydia Coulter |e VerfasserIn |4 aut | |
| 700 | 1 | |a Esko, Tõnu |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mihailov, Evelin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mägi, Reedik |e VerfasserIn |4 aut | |
| 700 | 1 | |a Milani, Lili |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fischer, Krista |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kanoni, Stavroula |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kumar, Jitender |e VerfasserIn |4 aut | |
| 700 | 1 | |a Song, Ci |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hartiala, Jaana A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pedersen, Nancy L. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Perola, Markus |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gieger, Christian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Peters, Annette |e VerfasserIn |4 aut | |
| 700 | 1 | |a Qu, Liming |e VerfasserIn |4 aut | |
| 700 | 1 | |a Willems, Sara M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Doney, Alex S.F. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Morris, Andrew D. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zheng, Yan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sesti, Giorgio |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hu, Frank B. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Qi, Lu |e VerfasserIn |4 aut | |
| 700 | 1 | |a Laakso, Markku |e VerfasserIn |4 aut | |
| 700 | 1 | |a Thorsteinsdottir, Unnur |e VerfasserIn |4 aut | |
| 700 | 1 | |a Grallert, Harald |e VerfasserIn |4 aut | |
| 700 | 1 | |a Duijn, Cornelia van |e VerfasserIn |4 aut | |
| 700 | 1 | |a Reilly, Muredach P. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ingelsson, Erik |e VerfasserIn |4 aut | |
| 700 | 1 | |a Deloukas, Panos |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kathiresan, Sek |e VerfasserIn |4 aut | |
| 700 | 1 | |a Metspalu, Andres |e VerfasserIn |4 aut | |
| 700 | 1 | |a Shah, Svati H. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sinisalo, Juha |e VerfasserIn |4 aut | |
| 700 | 1 | |a Salomaa, Veikko |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hamsten, Anders |e VerfasserIn |4 aut | |
| 700 | 1 | |a Samani, Nilesh J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a März, Winfried |d 1958- |e VerfasserIn |0 (DE-588)1027603599 |0 (DE-627)729463605 |0 (DE-576)373454635 |4 aut | |
| 700 | 1 | |a Hazen, Stanley L. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Watkins, Hugh |e VerfasserIn |4 aut | |
| 700 | 1 | |a Saleheen, Danish |e VerfasserIn |4 aut | |
| 700 | 1 | |a Morris, Andrew P. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Colhoun, Helen M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Groop, Leif |e VerfasserIn |4 aut | |
| 700 | 1 | |a McCarthy, Mark I. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Palmer, Colin N.A. |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Circulation. Genomic and precision medicine |d Philadelphia, Pa. : Lippincott, Williams & Wilkins, 2018 |g 13(2020), 6 vom: Dez., Artikel-ID e002769, Seite 640-648 |h Online-Ressource |w (DE-627)1019378298 |w (DE-600)2927603-2 |w (DE-576)502270454 |x 2574-8300 |7 nnas |a Genetic predisposition to coronary artery disease in type 2 diabetes mellitus |
| 773 | 1 | 8 | |g volume:13 |g year:2020 |g number:6 |g month:12 |g elocationid:e002769 |g pages:640-648 |g extent:9 |a Genetic predisposition to coronary artery disease in type 2 diabetes mellitus |
| 856 | 4 | 0 | |u https://doi.org/10.1161/CIRCGEN.119.002769 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.ahajournals.org/doi/10.1161/CIRCGEN.119.002769 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20240718 | ||
| 993 | |a Article | ||
| 994 | |a 2020 | ||
| 998 | |g 1027603599 |a März, Winfried |m 1027603599:März, Winfried |d 60000 |d 61400 |e 60000PM1027603599 |e 61400PM1027603599 |k 0/60000/ |k 1/60000/61400/ |p 49 | ||
| 999 | |a KXP-PPN1895762642 |e 4553279304 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedDisp":"December 2020","dateIssuedKey":"2020"}],"note":["Gesehen am 18.07.2024"],"recId":"1895762642","name":{"displayForm":["Natalie R. van Zuydam, Claes Ladenvall, Benjamin F. Voight, Rona J. Strawbridge, Juan Fernandez-Tajes, N. William Rayner, Neil R. Robertson, Anubha Mahajan, Efthymia Vlachopoulou, Anuj Goel, Marcus E. Kleber, Christopher P. Nelson, Lydia Coulter Kwee, Tõnu Esko, Evelin Mihailov, Reedik Mägi, Lili Milani, Krista Fischer, Stavroula Kanoni, Jitender Kumar, Ci Song, Jaana A. Hartiala, Nancy L. Pedersen, Markus Perola, Christian Gieger, Annette Peters, Liming Qu, Sara M. Willems, Alex S.F. Doney, Andrew D. Morris, Yan Zheng, Giorgio Sesti, Frank B. Hu, Lu Qi, Markku Laakso, Unnur Thorsteinsdottir, Harald Grallert, Cornelia van Duijn, Muredach P. Reilly, Erik Ingelsson, Panos Deloukas, Sek Kathiresan, Andres Metspalu, Svati H. Shah, Juha Sinisalo, Veikko Salomaa, Anders Hamsten, Nilesh J. Samani, Winfried März, Stanley L. Hazen, Hugh Watkins, Danish Saleheen, Andrew P. Morris, Helen M. Colhoun, Leif Groop, Mark I. McCarthy, Colin N.A. Palmer, SUMMIT Steering Committee; CARDIOGRAMplusC4D Steering Committee"]},"title":[{"title_sort":"Genetic predisposition to coronary artery disease in type 2 diabetes mellitus","title":"Genetic predisposition to coronary artery disease in type 2 diabetes mellitus"}],"relHost":[{"language":["eng"],"title":[{"title":"Circulation","partname":"Genomic and precision medicine","title_sort":"Circulation"}],"pubHistory":["Volume 11 (January 2018)-"],"part":{"extent":"9","year":"2020","volume":"13","text":"13(2020), 6 vom: Dez., Artikel-ID e002769, Seite 640-648","pages":"640-648","issue":"6"},"physDesc":[{"extent":"Online-Ressource"}],"id":{"zdb":["2927603-2"],"issn":["2574-8300"],"eki":["1019378298"]},"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Genetic predisposition to coronary artery disease in type 2 diabetes mellitusCirculation. Genomic and precision medicine","recId":"1019378298","name":{"displayForm":["American Heart Association"]},"titleAlt":[{"title":"Circ Genom Precis Med"}],"corporate":[{"display":"American Heart Association","role":"isb"}],"origin":[{"publisherPlace":"Philadelphia, Pa.","publisher":"Lippincott, Williams & Wilkins","dateIssuedDisp":"January 16, 2018"}]}],"physDesc":[{"extent":"9 S.","noteIll":"Illustrationen"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"eki":["1895762642"],"doi":["10.1161/CIRCGEN.119.002769"]},"person":[{"role":"aut","display":"Zuydam, Natalie van","given":"Natalie van","family":"Zuydam"},{"display":"Ladenvall, Claes","role":"aut","family":"Ladenvall","given":"Claes"},{"given":"Benjamin F.","family":"Voight","role":"aut","display":"Voight, Benjamin F."},{"role":"aut","display":"Strawbridge, Rona J.","given":"Rona J.","family":"Strawbridge"},{"display":"Fernandez-Tajes, Juan","role":"aut","family":"Fernandez-Tajes","given":"Juan"},{"given":"N. William","family":"Rayner","role":"aut","display":"Rayner, N. William"},{"role":"aut","display":"Robertson, Neil R.","given":"Neil R.","family":"Robertson"},{"role":"aut","display":"Mahajan, Anubha","given":"Anubha","family":"Mahajan"},{"display":"Vlachopoulou, Efthymia","role":"aut","family":"Vlachopoulou","given":"Efthymia"},{"given":"Anuj","family":"Goel","role":"aut","display":"Goel, Anuj"},{"family":"Kleber","given":"Marcus E.","display":"Kleber, Marcus E.","role":"aut"},{"given":"Christopher P.","family":"Nelson","role":"aut","display":"Nelson, Christopher P."},{"display":"Kwee, Lydia Coulter","role":"aut","family":"Kwee","given":"Lydia Coulter"},{"display":"Esko, Tõnu","role":"aut","family":"Esko","given":"Tõnu"},{"family":"Mihailov","given":"Evelin","display":"Mihailov, Evelin","role":"aut"},{"display":"Mägi, Reedik","role":"aut","family":"Mägi","given":"Reedik"},{"role":"aut","display":"Milani, Lili","given":"Lili","family":"Milani"},{"given":"Krista","family":"Fischer","role":"aut","display":"Fischer, Krista"},{"given":"Stavroula","family":"Kanoni","role":"aut","display":"Kanoni, Stavroula"},{"role":"aut","display":"Kumar, Jitender","given":"Jitender","family":"Kumar"},{"role":"aut","display":"Song, Ci","given":"Ci","family":"Song"},{"family":"Hartiala","given":"Jaana A.","display":"Hartiala, Jaana A.","role":"aut"},{"given":"Nancy L.","family":"Pedersen","role":"aut","display":"Pedersen, Nancy L."},{"display":"Perola, Markus","role":"aut","family":"Perola","given":"Markus"},{"role":"aut","display":"Gieger, Christian","given":"Christian","family":"Gieger"},{"role":"aut","display":"Peters, Annette","given":"Annette","family":"Peters"},{"given":"Liming","family":"Qu","role":"aut","display":"Qu, Liming"},{"given":"Sara M.","family":"Willems","role":"aut","display":"Willems, Sara M."},{"given":"Alex S.F.","family":"Doney","role":"aut","display":"Doney, Alex S.F."},{"given":"Andrew D.","family":"Morris","role":"aut","display":"Morris, Andrew D."},{"family":"Zheng","given":"Yan","display":"Zheng, Yan","role":"aut"},{"display":"Sesti, Giorgio","role":"aut","family":"Sesti","given":"Giorgio"},{"given":"Frank B.","family":"Hu","role":"aut","display":"Hu, Frank B."},{"role":"aut","display":"Qi, Lu","given":"Lu","family":"Qi"},{"family":"Laakso","given":"Markku","display":"Laakso, Markku","role":"aut"},{"family":"Thorsteinsdottir","given":"Unnur","display":"Thorsteinsdottir, Unnur","role":"aut"},{"given":"Harald","family":"Grallert","role":"aut","display":"Grallert, Harald"},{"given":"Cornelia van","family":"Duijn","role":"aut","display":"Duijn, Cornelia van"},{"role":"aut","display":"Reilly, Muredach P.","given":"Muredach P.","family":"Reilly"},{"family":"Ingelsson","given":"Erik","display":"Ingelsson, Erik","role":"aut"},{"given":"Panos","family":"Deloukas","role":"aut","display":"Deloukas, Panos"},{"display":"Kathiresan, Sek","role":"aut","family":"Kathiresan","given":"Sek"},{"given":"Andres","family":"Metspalu","role":"aut","display":"Metspalu, Andres"},{"given":"Svati H.","family":"Shah","role":"aut","display":"Shah, Svati H."},{"family":"Sinisalo","given":"Juha","display":"Sinisalo, Juha","role":"aut"},{"family":"Salomaa","given":"Veikko","display":"Salomaa, Veikko","role":"aut"},{"display":"Hamsten, Anders","role":"aut","family":"Hamsten","given":"Anders"},{"family":"Samani","given":"Nilesh J.","display":"Samani, Nilesh J.","role":"aut"},{"display":"März, Winfried","role":"aut","family":"März","given":"Winfried"},{"given":"Stanley L.","family":"Hazen","role":"aut","display":"Hazen, Stanley L."},{"role":"aut","display":"Watkins, Hugh","given":"Hugh","family":"Watkins"},{"family":"Saleheen","given":"Danish","display":"Saleheen, Danish","role":"aut"},{"family":"Morris","given":"Andrew P.","display":"Morris, Andrew P.","role":"aut"},{"given":"Helen M.","family":"Colhoun","role":"aut","display":"Colhoun, Helen M."},{"role":"aut","display":"Groop, Leif","given":"Leif","family":"Groop"},{"role":"aut","display":"McCarthy, Mark I.","given":"Mark I.","family":"McCarthy"},{"display":"Palmer, Colin N.A.","role":"aut","family":"Palmer","given":"Colin N.A."}],"language":["eng"]} | ||
| SRT | |a ZUYDAMNATAGENETICPRE2020 | ||