Neural correlates of adolescent irritability and its comorbidity with psychiatric disorders
Objective - Irritable mood, a common and impairing symptom in psychopathology, has been proposed to underlie the developmental link between oppositional problems in youth and depression in adulthood. We examined the neural correlates of adolescent irritability in IMAGEN, a sample of 2,024 14-year-ol...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2020
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| In: |
Journal of the American Academy of Child and Adolescent Psychiatry
Year: 2020, Jahrgang: 59, Heft: 12, Pages: 1371-1379 |
| ISSN: | 1527-5418 |
| DOI: | 10.1016/j.jaac.2019.11.028 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.jaac.2019.11.028 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S0890856720313551 
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| Verfasserangaben: | Bader Chaarani, Kees-Jan Kan, Scott Mackey, Philip A. Spechler, Alexandra Potter, Tobias Banaschewski, Sabina Millenet, Arun L.W. Bokde, Uli Bromberg, Christian Büchel, Anna Cattrell, Patricia J. Conrod, Sylvane Desrivières, Herta Flor, Vincent Frouin, Jürgen Gallinat, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Frauke Nees, Tomáš Paus, Luise Poustka, Michael N. Smolka, Henrik Walter, Robert Whelan, Argyris Stringaris, Stephen T. Higgins, Gunter Schumann, Hugh Garavan, Robert R. Althoff, the IMAGEN Consortium |
MARC
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| 245 | 1 | 0 | |a Neural correlates of adolescent irritability and its comorbidity with psychiatric disorders |c Bader Chaarani, Kees-Jan Kan, Scott Mackey, Philip A. Spechler, Alexandra Potter, Tobias Banaschewski, Sabina Millenet, Arun L.W. Bokde, Uli Bromberg, Christian Büchel, Anna Cattrell, Patricia J. Conrod, Sylvane Desrivières, Herta Flor, Vincent Frouin, Jürgen Gallinat, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Frauke Nees, Tomáš Paus, Luise Poustka, Michael N. Smolka, Henrik Walter, Robert Whelan, Argyris Stringaris, Stephen T. Higgins, Gunter Schumann, Hugh Garavan, Robert R. Althoff, the IMAGEN Consortium |
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| 500 | |a Gesehen am 19.07.2024 | ||
| 520 | |a Objective - Irritable mood, a common and impairing symptom in psychopathology, has been proposed to underlie the developmental link between oppositional problems in youth and depression in adulthood. We examined the neural correlates of adolescent irritability in IMAGEN, a sample of 2,024 14-year-old adolescents from 5 European countries. - Method - The Development and Well-Being Assessment (DAWBA) was used to assess attention-deficit/hyperactivity disorder, major depressive disorder, oppositional defiant disorder, and generalized anxiety disorder. Three items from the DAWBA, selected as close matches to the Affective Reactivity Index, were used to assess irritability. Structural magnetic resonance imaging was examined using whole-brain voxel-based morphometry analysis, and functional magnetic resonance imaging was examined during a stop signal task of inhibitory control. Imaging data were included in structural equation models to examine the direct and indirect associations between irritable mood and comorbid DSM diagnoses. - Results - Whole-brain voxelwise analysis showed that adolescent irritable mood was associated with less gray matter volume and less neural activation underlying inhibitory control in frontal and temporal cortical areas (cluster-correction at p < .05). Structural equation models suggested that part of the observed smaller gray matter volume was exclusively driven by irritability separate from direct relationships between generalized anxiety disorder (or attention-deficit/hyperactivity disorder, major depressive disorder, or oppositional defiant disorder) and gray matter volume. - Conclusion - This study identifies adolescent irritability as an independent construct and points to a neurobiological correlate to irritability that is an important contributing feature to many psychopathological disorders. | ||
| 650 | 4 | |a adolescent irritability | |
| 650 | 4 | |a gray matter volume | |
| 650 | 4 | |a inhibitory control | |
| 650 | 4 | |a psychopathology | |
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| 700 | 1 | |a Mackey, Scott |e VerfasserIn |4 aut | |
| 700 | 1 | |a Spechler, Philip A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Potter, Alexandra |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Ittermann, Bernd |e VerfasserIn |4 aut | |
| 700 | 1 | |a Martinot, Jean-Luc |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nees, Frauke |e VerfasserIn |4 aut | |
| 700 | 1 | |a Paus, Tomáš |e VerfasserIn |4 aut | |
| 700 | 1 | |a Poustka, Luise |e VerfasserIn |0 (DE-588)1032378239 |0 (DE-627)738388688 |0 (DE-576)380005190 |4 aut | |
| 700 | 1 | |a Smolka, Michael N. |e VerfasserIn |4 aut | |
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