Humoral SARS-CoV-2 Immune Response in COVID-19 Recovered Vaccinated and Unvaccinated Individuals Related to Post-COVID-Syndrome
Background: The duration of anti-SARS-CoV-2-antibody detectability up to 12 months was examined in individuals after either single convalescence or convalescence and vaccination. Moreover, variables that might influence an anti-RBD/S1 antibody decline and the existence of a post-COVID-syndrome (PCS)...
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| Hauptverfasser: | , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
6 February 2023
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| In: |
Viruses
Year: 2023, Jahrgang: 15, Heft: 2, Pages: 1-18 |
| ISSN: | 1999-4915 |
| DOI: | 10.3390/v15020454 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/v15020454 Verlag, kostenfrei, Volltext: https://www.mdpi.com/1999-4915/15/2/454 
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| Verfasserangaben: | Catharina Gerhards, Maximilian Kittel, Volker Ast, Peter Bugert, Matthias F. Froelich, Michael Hetjens, Verena Haselmann, Michael Neumaier and Margot Thiaucourt |
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| 245 | 1 | 0 | |a Humoral SARS-CoV-2 Immune Response in COVID-19 Recovered Vaccinated and Unvaccinated Individuals Related to Post-COVID-Syndrome |c Catharina Gerhards, Maximilian Kittel, Volker Ast, Peter Bugert, Matthias F. Froelich, Michael Hetjens, Verena Haselmann, Michael Neumaier and Margot Thiaucourt |
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| 520 | |a Background: The duration of anti-SARS-CoV-2-antibody detectability up to 12 months was examined in individuals after either single convalescence or convalescence and vaccination. Moreover, variables that might influence an anti-RBD/S1 antibody decline and the existence of a post-COVID-syndrome (PCS) were addressed. Methods: Forty-nine SARS-CoV-2-qRT-PCR-confirmed participants completed a 12-month examination of anti-SARS-CoV-2-antibody levels and PCS-associated long-term sequelae. Overall, 324 samples were collected. Cell-free DNA (cfDNA) was isolated and quantified from EDTA-plasma. As cfDNA is released into the bloodstream from dying cells, it might provide information on organ damage in the late recovery of COIVD-19. Therefore, we evaluated cfDNA concentrations as a biomarker for a PCS. In the context of antibody dynamics, a random forest-based logistic regression with antibody decline as the target was performed and internally validated. Results: The mean percentage dynamic related to the maximum measured value was 96 (±38)% for anti-RBD/S1 antibodies and 30 (±26)% for anti-N antibodies. Anti-RBD/S1 antibodies decreased in 37%, whereas anti-SARS-CoV-2-anti-N antibodies decreased in 86% of the subjects. Clinical anti-RBD/S1 antibody decline prediction models, including vascular and other diseases, were cross-validated (highest AUC 0.74). Long-term follow-up revealed no significant reduction in PCS prevalence but an increase in cognitive impairment, with no indication for cfDNA as a marker for a PCS. Conclusion: Long-term anti-RBD/S1-antibody positivity was confirmed, and clinical parameters associated with declining titers were presented. A fulminant decrease in anti-SARS-CoV-2-anti-N antibodies was observed (mean change to maximum value 30 (±26)%). Anti-RBD/S1 antibody titers of SARS-CoV-2 recovered subjects boosted with a vaccine exceeded the maximum values measured after single infection by 235 ± 382-fold, with no influence on preexisting PCS. PCS long-term prevalence was 38.6%, with an increase in cognitive impairment compromising the quality of life. Quantified cfDNA measured in the early post-COVID-19 phase might not be an effective marker for PCS identification. | ||
| 650 | 4 | |a anti-SARS-CoV-2 antibodies | |
| 650 | 4 | |a antibody dynamics | |
| 650 | 4 | |a antibody kinetics | |
| 650 | 4 | |a longitudinal assessment | |
| 650 | 4 | |a post-COVID syndrome | |
| 650 | 4 | |a post-vaccination boosting | |
| 650 | 4 | |a serological immune response | |
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