Queuosine‐tRNA promotes sex‐dependent learning and memory formation by maintaining codon‐biased translation elongation speed
Queuosine (Q) is a modified nucleoside at the wobble position of specific tRNAs. In mammals, queuosinylation is facilitated by queuine uptake from the gut microbiota and is introduced into tRNA by the QTRT1‐QTRT2 enzyme complex. By establishing a Qtrt1 knockout mouse model, we discovered that the lo...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
23 August 2023
|
| In: |
The EMBO journal
Year: 2023, Jahrgang: 42, Heft: 19, Pages: 1-20 |
| ISSN: | 1460-2075 |
| DOI: | 10.15252/embj.2022112507 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.15252/embj.2022112507 Verlag, kostenfrei, Volltext: https://www.embopress.org/doi/full/10.15252/embj.2022112507 
|
| Verfasserangaben: | Cansu Cirzi, Julia Dyckow, Carine Legrand, Johanna Schott, Wei Guo, Daniel Perez Hernandez, Miharu Hisaoka, Rosanna Parlato, Claudia Pitzer, Franciscus van der Hoeven, Gunnar Dittmar, Mark Helm, Georg Stoecklin, Lucas Schirmer, Frank Lyko & Francesca Tuorto |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1896177697 | ||
| 003 | DE-627 | ||
| 005 | 20260105113412.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240724s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.15252/embj.2022112507 |2 doi | |
| 035 | |a (DE-627)1896177697 | ||
| 035 | |a (DE-599)KXP1896177697 | ||
| 035 | |a (OCoLC)1475304100 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Cirzi, Cansu |d 1993- |e VerfasserIn |0 (DE-588)1188493809 |0 (DE-627)1667481363 |4 aut | |
| 245 | 1 | 0 | |a Queuosine‐tRNA promotes sex‐dependent learning and memory formation by maintaining codon‐biased translation elongation speed |c Cansu Cirzi, Julia Dyckow, Carine Legrand, Johanna Schott, Wei Guo, Daniel Perez Hernandez, Miharu Hisaoka, Rosanna Parlato, Claudia Pitzer, Franciscus van der Hoeven, Gunnar Dittmar, Mark Helm, Georg Stoecklin, Lucas Schirmer, Frank Lyko & Francesca Tuorto |
| 264 | 1 | |c 23 August 2023 | |
| 300 | |a 20 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 24.07.2024 | ||
| 520 | |a Queuosine (Q) is a modified nucleoside at the wobble position of specific tRNAs. In mammals, queuosinylation is facilitated by queuine uptake from the gut microbiota and is introduced into tRNA by the QTRT1‐QTRT2 enzyme complex. By establishing a Qtrt1 knockout mouse model, we discovered that the loss of Q‐tRNA leads to learning and memory deficits. Ribo‐Seq analysis in the hippocampus of Qtrt1‐deficient mice revealed not only stalling of ribosomes on Q‐decoded codons, but also a global imbalance in translation elongation speed between codons that engage in weak and strong interactions with their cognate anticodons. While Q‐dependent molecular and behavioral phenotypes were identified in both sexes, female mice were affected more severely than males. Proteomics analysis confirmed deregulation of synaptogenesis and neuronal morphology. Together, our findings provide a link between tRNA modification and brain functions and reveal an unexpected role of protein synthesis in sex‐dependent cognitive performance. | ||
| 650 | 4 | |a learning and memory | |
| 650 | 4 | |a protein translation | |
| 650 | 4 | |a queuosine | |
| 650 | 4 | |a sex bias | |
| 650 | 4 | |a tRNA modifications | |
| 700 | 1 | |a Dyckow, Julia |d 1994- |e VerfasserIn |0 (DE-588)1235711439 |0 (DE-627)1760723479 |4 aut | |
| 700 | 1 | |a Legrand, Carine |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schott, Johanna |d 1985- |e VerfasserIn |0 (DE-588)1057923079 |0 (DE-627)795534477 |0 (DE-576)413926125 |4 aut | |
| 700 | 1 | |a Guo, Wei |d 1995- |e VerfasserIn |0 (DE-588)133672627X |0 (DE-627)1896179983 |4 aut | |
| 700 | 1 | |a Perez Hernandez, Daniel |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hisaoka, Miharu |e VerfasserIn |0 (DE-588)1261359836 |0 (DE-627)1808545745 |4 aut | |
| 700 | 1 | |a Parlato, Rosanna |d 1973- |e VerfasserIn |0 (DE-588)1064026451 |0 (DE-627)812875338 |0 (DE-576)415235642 |4 aut | |
| 700 | 1 | |a Pitzer, Claudia |e VerfasserIn |4 aut | |
| 700 | 1 | |a van der Hoeven, Franciscus |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dittmar, Gunnar |e VerfasserIn |4 aut | |
| 700 | 1 | |a Helm, Mark |e VerfasserIn |4 aut | |
| 700 | 1 | |a Stoecklin, Georg |d 1969- |e VerfasserIn |0 (DE-588)1068935596 |0 (DE-627)821071475 |0 (DE-576)428310036 |4 aut | |
| 700 | 1 | |a Schirmer, Lucas |d 1981- |e VerfasserIn |0 (DE-588)140880631 |0 (DE-627)70381737X |0 (DE-576)321212088 |4 aut | |
| 700 | 1 | |a Lyko, Frank |e VerfasserIn |0 (DE-588)1106120361 |0 (DE-627)862900018 |0 (DE-576)473860597 |4 aut | |
| 700 | 1 | |a Tuorto, Francesca |e VerfasserIn |0 (DE-588)1122208154 |0 (DE-627)875231187 |0 (DE-576)481189092 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |a European Molecular Biology Organization |t The EMBO journal |d [London] : Nature Publishing Group UK, 1982 |g 42(2023), 19, Artikel-ID e112507, Seite 1-20 |h Online-Ressource |w (DE-627)266022529 |w (DE-600)1467419-1 |w (DE-576)075961377 |x 1460-2075 |7 nnas |
| 773 | 1 | 8 | |g volume:42 |g year:2023 |g number:19 |g elocationid:e112507 |g pages:1-20 |g extent:20 |a Queuosine‐tRNA promotes sex‐dependent learning and memory formation by maintaining codon‐biased translation elongation speed |
| 856 | 4 | 0 | |u https://doi.org/10.15252/embj.2022112507 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |7 0 |
| 856 | 4 | 0 | |u https://www.embopress.org/doi/full/10.15252/embj.2022112507 |x Verlag |z kostenfrei |3 Volltext |7 0 |
| 951 | |a AR | ||
| 992 | |a 20240724 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 1122208154 |a Tuorto, Francesca |m 1122208154:Tuorto, Francesca |d 60000 |d 65400 |e 60000PT1122208154 |e 65400PT1122208154 |k 0/60000/ |k 1/60000/65400/ |p 16 |y j | ||
| 998 | |g 1106120361 |a Lyko, Frank |m 1106120361:Lyko, Frank |d 50000 |e 50000PL1106120361 |k 0/50000/ |p 15 | ||
| 998 | |g 140880631 |a Schirmer, Lucas |m 140880631:Schirmer, Lucas |d 60000 |d 62700 |e 60000PS140880631 |e 62700PS140880631 |k 0/60000/ |k 1/60000/62700/ |p 14 | ||
| 998 | |g 1068935596 |a Stoecklin, Georg |m 1068935596:Stoecklin, Georg |d 60000 |d 65400 |e 60000PS1068935596 |e 65400PS1068935596 |k 0/60000/ |k 1/60000/65400/ |p 13 | ||
| 998 | |g 1064026451 |a Parlato, Rosanna |m 1064026451:Parlato, Rosanna |d 60000 |d 62700 |e 60000PP1064026451 |e 62700PP1064026451 |k 0/60000/ |k 1/60000/62700/ |p 8 | ||
| 998 | |g 1261359836 |a Hisaoka, Miharu |m 1261359836:Hisaoka, Miharu |p 7 | ||
| 998 | |g 133672627X |a Guo, Wei |m 133672627X:Guo, Wei |d 60000 |d 65400 |e 60000PG133672627X |e 65400PG133672627X |k 0/60000/ |k 1/60000/65400/ |p 5 | ||
| 998 | |g 1057923079 |a Schott, Johanna |m 1057923079:Schott, Johanna |d 60000 |d 65400 |e 60000PS1057923079 |e 65400PS1057923079 |k 0/60000/ |k 1/60000/65400/ |p 4 | ||
| 998 | |g 1235711439 |a Dyckow, Julia |m 1235711439:Dyckow, Julia |d 60000 |d 62700 |e 60000PD1235711439 |e 62700PD1235711439 |k 0/60000/ |k 1/60000/62700/ |p 2 | ||
| 999 | |a KXP-PPN1896177697 |e 4556676762 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"recId":"266022529","physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 18.02.2016","Fortsetzung der Druckausgabe"],"corporate":[{"role":"aut","display":"European Molecular Biology Organization"}],"titleAlt":[{"title":"The EMBO journal online"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"pubHistory":["1.1982 -"],"language":["eng"],"origin":[{"dateIssuedDisp":"1982-","publisherPlace":"[London] ; Heidelberg ; Oxford [u.a.] ; London [u.a.] ; Hoboken, NJ [u.a.]","dateIssuedKey":"1982","publisher":"Nature Publishing Group UK ; EMBO Press ; Oxford Univ. Press ; Nature Publ. Group ; Wiley"}],"id":{"issn":["1460-2075"],"eki":["266022529"],"zdb":["1467419-1"],"doi":["10.1002/(ISSN)1460-2075"]},"part":{"volume":"42","extent":"20","issue":"19","pages":"1-20","text":"42(2023), 19, Artikel-ID e112507, Seite 1-20","year":"2023"},"title":[{"title_sort":"EMBO journal","title":"The EMBO journal"}],"disp":"European Molecular Biology OrganizationThe EMBO journal","name":{"displayForm":["publ. for the European Molecular Biology Organization"]}}],"recId":"1896177697","physDesc":[{"extent":"20 S."}],"language":["eng"],"note":["Gesehen am 24.07.2024"],"id":{"doi":["10.15252/embj.2022112507"],"eki":["1896177697"]},"person":[{"given":"Cansu","family":"Cirzi","display":"Cirzi, Cansu","role":"aut"},{"given":"Julia","role":"aut","display":"Dyckow, Julia","family":"Dyckow"},{"given":"Carine","display":"Legrand, Carine","role":"aut","family":"Legrand"},{"given":"Johanna","role":"aut","display":"Schott, Johanna","family":"Schott"},{"given":"Wei","family":"Guo","role":"aut","display":"Guo, Wei"},{"given":"Daniel","display":"Perez Hernandez, Daniel","role":"aut","family":"Perez Hernandez"},{"given":"Miharu","role":"aut","display":"Hisaoka, Miharu","family":"Hisaoka"},{"family":"Parlato","role":"aut","display":"Parlato, Rosanna","given":"Rosanna"},{"given":"Claudia","display":"Pitzer, Claudia","role":"aut","family":"Pitzer"},{"given":"Franciscus","family":"van der Hoeven","display":"van der Hoeven, Franciscus","role":"aut"},{"given":"Gunnar","role":"aut","display":"Dittmar, Gunnar","family":"Dittmar"},{"given":"Mark","family":"Helm","role":"aut","display":"Helm, Mark"},{"display":"Stoecklin, Georg","role":"aut","family":"Stoecklin","given":"Georg"},{"given":"Lucas","display":"Schirmer, Lucas","role":"aut","family":"Schirmer"},{"given":"Frank","display":"Lyko, Frank","role":"aut","family":"Lyko"},{"role":"aut","display":"Tuorto, Francesca","family":"Tuorto","given":"Francesca"}],"origin":[{"dateIssuedDisp":"23 August 2023","dateIssuedKey":"2023"}],"name":{"displayForm":["Cansu Cirzi, Julia Dyckow, Carine Legrand, Johanna Schott, Wei Guo, Daniel Perez Hernandez, Miharu Hisaoka, Rosanna Parlato, Claudia Pitzer, Franciscus van der Hoeven, Gunnar Dittmar, Mark Helm, Georg Stoecklin, Lucas Schirmer, Frank Lyko & Francesca Tuorto"]},"title":[{"title_sort":"Queuosine‐tRNA promotes sex‐dependent learning and memory formation by maintaining codon‐biased translation elongation speed","title":"Queuosine‐tRNA promotes sex‐dependent learning and memory formation by maintaining codon‐biased translation elongation speed"}],"type":{"bibl":"article-journal","media":"Online-Ressource"}} | ||
| SRT | |a CIRZICANSUQUEUOSINET2320 | ||