Clinical characterization of HCC/CCA mixed cancers in a population-based cohort: original article
Background and Aims: Primary liver cancer (PLC) ranks among of the most common cancers worldwide. Within this group, a minority of cases displays characteristics of both hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA), known as combined hepatocellular cholangiocarcinoma (cH...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
June 2023
|
| In: |
Journal of gastrointestinal and liver diseases
Year: 2023, Jahrgang: 32, Heft: 2, Pages: 190-196 |
| ISSN: | 1842-1121 |
| DOI: | 10.15403/jgld-4893 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.15403/jgld-4893 Verlag, lizenzpflichtig, Volltext: https://jgld.ro/jgld/index.php/jgld/article/view/4893 
|
| Verfasserangaben: | Andreas Teufel, Isaac Rodriguez, Claudia Winzler, Daria Kokh, Matthias P. Ebert, Irina Surovtsova, Philipp Morakis |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1896189105 | ||
| 003 | DE-627 | ||
| 005 | 20241205154120.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240724s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.15403/jgld-4893 |2 doi | |
| 035 | |a (DE-627)1896189105 | ||
| 035 | |a (DE-599)KXP1896189105 | ||
| 035 | |a (OCoLC)1475303836 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Teufel, Andreas |d 1971- |e VerfasserIn |0 (DE-588)121120031 |0 (DE-627)081100035 |0 (DE-576)292546750 |4 aut | |
| 245 | 1 | 0 | |a Clinical characterization of HCC/CCA mixed cancers in a population-based cohort |b original article |c Andreas Teufel, Isaac Rodriguez, Claudia Winzler, Daria Kokh, Matthias P. Ebert, Irina Surovtsova, Philipp Morakis |
| 264 | 1 | |c June 2023 | |
| 300 | |b Illustrationen | ||
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 24.07.2024 | ||
| 520 | |a Background and Aims: Primary liver cancer (PLC) ranks among of the most common cancers worldwide. Within this group, a minority of cases displays characteristics of both hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA), known as combined hepatocellular cholangiocarcinoma (cHCC- CCA). Currently, there is no specific standardized therapy for these mixed tumors. Therefore, the aim of our study was to analyze the clinical course, treatment and outcome of cHCC-CCA patients in a European population-based registry. - Methods: We investigated 9,144 patients with PLC (6,622 HCC, 2,356 iCCA, and 166 cHCC-CCA) diagnosed between 2009 and 2020. All data were obtained from Clinical Cancer Registry of Baden-Württemberg (BW), Germany. - Results: In all three groups patients were predominantly male (82%, 57%, and 68% for HCC, iCCA and cHCC-CCA groups, respectively). 48% of cHCC-CCA patients were diagnosed as stage IV cancers, which was more than for HCC (31%) but less compared to CCA (64%). Overall median survival of cHCC-CCA patients was worse compared to HCC (9-13 months vs. 15.5 months, p<0.001) and rather comparable to CCA (11.8 months). - Conclusions: Our data demonstrated that cHCC-CCA tumors appear to have a distinct clinical course with worse overall survival compared to HCC. Thus, identification of these cancers by histopathology is essential in order to further characterize this tumor entity and to provide accurate treatment to these patients. | ||
| 650 | 4 | |a combined hepatocellular cholangiocarcinoma | |
| 650 | 4 | |a hepatocellular carcinoma | |
| 650 | 4 | |a histological diagnosis | |
| 650 | 4 | |a intrahepatic cholangiocarcinoma | |
| 650 | 4 | |a survival | |
| 700 | 1 | |a Rodriguez, Isaac |e VerfasserIn |0 (DE-588)1323875816 |0 (DE-627)1883788595 |4 aut | |
| 700 | 1 | |a Winzler, Claudia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kokh, Daria |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ebert, Matthias |d 1968- |e VerfasserIn |0 (DE-588)1030133522 |0 (DE-627)734827083 |0 (DE-576)377938432 |4 aut | |
| 700 | 1 | |a Surovtsova, Irina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Morakis, Philipp |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of gastrointestinal and liver diseases |d Cluj-Napoca : Soc., 2006 |g 32(2023), 2 vom: Juni, Seite 190-196 |h Online-Ressource |w (DE-627)518632555 |w (DE-600)2253255-9 |w (DE-576)281384517 |x 1842-1121 |7 nnas |a Clinical characterization of HCC/CCA mixed cancers in a population-based cohort original article |
| 773 | 1 | 8 | |g volume:32 |g year:2023 |g number:2 |g month:06 |g pages:190-196 |g extent:7 |a Clinical characterization of HCC/CCA mixed cancers in a population-based cohort original article |
| 856 | 4 | 0 | |u https://doi.org/10.15403/jgld-4893 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://jgld.ro/jgld/index.php/jgld/article/view/4893 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20240724 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 1030133522 |a Ebert, Matthias |m 1030133522:Ebert, Matthias |d 60000 |d 61100 |e 60000PE1030133522 |e 61100PE1030133522 |k 0/60000/ |k 1/60000/61100/ |p 5 | ||
| 998 | |g 1323875816 |a Rodriguez, Isaac |m 1323875816:Rodriguez, Isaac |d 60000 |d 61100 |e 60000PR1323875816 |e 61100PR1323875816 |k 0/60000/ |k 1/60000/61100/ |p 2 | ||
| 998 | |g 121120031 |a Teufel, Andreas |m 121120031:Teufel, Andreas |d 60000 |d 61100 |e 60000PT121120031 |e 61100PT121120031 |k 0/60000/ |k 1/60000/61100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1896189105 |e 4556719976 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title_sort":"Clinical characterization of HCC/CCA mixed cancers in a population-based cohort","subtitle":"original article","title":"Clinical characterization of HCC/CCA mixed cancers in a population-based cohort"}],"person":[{"display":"Teufel, Andreas","family":"Teufel","role":"aut","given":"Andreas"},{"display":"Rodriguez, Isaac","family":"Rodriguez","given":"Isaac","role":"aut"},{"display":"Winzler, Claudia","family":"Winzler","given":"Claudia","role":"aut"},{"display":"Kokh, Daria","role":"aut","given":"Daria","family":"Kokh"},{"family":"Ebert","given":"Matthias","role":"aut","display":"Ebert, Matthias"},{"family":"Surovtsova","role":"aut","given":"Irina","display":"Surovtsova, Irina"},{"family":"Morakis","given":"Philipp","role":"aut","display":"Morakis, Philipp"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"physDesc":[{"extent":"7 S.","noteIll":"Illustrationen"}],"language":["eng"],"origin":[{"dateIssuedDisp":"June 2023","dateIssuedKey":"2023"}],"id":{"doi":["10.15403/jgld-4893"],"eki":["1896189105"]},"recId":"1896189105","name":{"displayForm":["Andreas Teufel, Isaac Rodriguez, Claudia Winzler, Daria Kokh, Matthias P. Ebert, Irina Surovtsova, Philipp Morakis"]},"note":["Gesehen am 24.07.2024"],"relHost":[{"recId":"518632555","disp":"Clinical characterization of HCC/CCA mixed cancers in a population-based cohort original articleJournal of gastrointestinal and liver diseases","id":{"eki":["518632555"],"issn":["1842-1121"],"zdb":["2253255-9"]},"origin":[{"dateIssuedKey":"2006","publisher":"Soc.","dateIssuedDisp":"2006-","publisherPlace":"Cluj-Napoca"}],"part":{"extent":"7","text":"32(2023), 2 vom: Juni, Seite 190-196","volume":"32","pages":"190-196","year":"2023","issue":"2"},"type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 19.10.20"],"physDesc":[{"extent":"Online-Ressource"}],"pubHistory":["15.2006 -"],"language":["eng"],"title":[{"title_sort":"Journal of gastrointestinal and liver diseases","title":"Journal of gastrointestinal and liver diseases","subtitle":"official journal of the Romanian Societies of Gastroenterology"}]}]} | ||
| SRT | |a TEUFELANDRCLINICALCH2023 | ||