Cover Image

Pathophysiology of trauma-induced coagulopathy

Trauma-induced coagulopathy (TIC) is a complex hemostatic disturbance that can develop early after a major injury. There is no universally accepted definition of TIC. However, TIC primarily refers to the inability to achieve sufficient hemostasis in severely injured trauma patients, resulting in dif...

Full description

Saved in:
Bibliographic Details
Main Authors: Schöchl, Herbert (Author) , Schmitt, Felix (Author) , Maegele, Marc (Author)
Format: Article (Journal)
Language:English
German
Published: 28. Februar 2024
In: Hämostaseologie
Year: 2024, Volume: 44, Issue: 01, Pages: 31-39
ISSN:2567-5761
DOI:10.1055/a-2215-8936
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1055/a-2215-8936
Verlag, lizenzpflichtig, Volltext: http://www.thieme-connect.de/DOI/DOI?10.1055/a-2215-8936
Get full text
Author Notes:Herbert Schöchl, Felix C.F. Schmitt, Marc Maegele

MARC

LEADER 00000caa a2200000 c 4500
001 1896412262
003 DE-627
005 20241205154326.0
007 cr uuu---uuuuu
008 240725s2024 xx |||||o 00| ||eng c
024 7 |a 10.1055/a-2215-8936  |2 doi 
035 |a (DE-627)1896412262 
035 |a (DE-599)KXP1896412262 
035 |a (OCoLC)1475304376 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng  |h ger 
084 |a 33  |2 sdnb 
100 1 |a Schöchl, Herbert  |e VerfasserIn  |0 (DE-588)133684583X  |0 (DE-627)1896413072  |4 aut 
245 1 0 |a Pathophysiology of trauma-induced coagulopathy  |c Herbert Schöchl, Felix C.F. Schmitt, Marc Maegele 
264 1 |c 28. Februar 2024 
300 |b Illustrationen 
300 |a 9 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 25.07.2024 
500 |a Zusammenfassung in deutscher Sprache 
520 |a Trauma-induced coagulopathy (TIC) is a complex hemostatic disturbance that can develop early after a major injury. There is no universally accepted definition of TIC. However, TIC primarily refers to the inability to achieve sufficient hemostasis in severely injured trauma patients, resulting in diffuse microvascular and life-threatening bleeding. Endogenous TIC is driven by the combination of hypovolemic shock and substantial tissue injury, resulting in endothelial damage, glycocalyx shedding, upregulated fibrinolysis, fibrinogen depletion, altered thrombin generation, and platelet dysfunction. Exogenous factors such as hypothermia, acidosis, hypokalemia, and dilution due to crystalloid and colloid fluid administration can further exacerbate TIC. Established TIC upon emergency room admission is a prognostic indicator and is strongly associated with poor outcomes. It has been shown that patients with TIC are prone to higher bleeding tendencies, increased requirements for allogeneic blood transfusion, higher complication rates such as multi-organ failure, and an almost fourfold increase in mortality. Thus, early recognition and individualized treatment of TIC is a cornerstone of initial trauma care. However, patients who survive the initial insult switch from hypocoagulability to hypercoagulability, also termed “late TIC,” with a high risk of developing thromboembolic complications. 
700 1 |a Schmitt, Felix  |d 1983-  |e VerfasserIn  |0 (DE-588)1038428327  |0 (DE-627)757395775  |0 (DE-576)392394375  |4 aut 
700 1 |a Maegele, Marc  |d 1968-  |e VerfasserIn  |0 (DE-588)123617030  |0 (DE-627)706369483  |0 (DE-576)293792402  |4 aut 
773 0 8 |i Enthalten in  |t Hämostaseologie  |d Stuttgart : Thieme, 1981  |g 44(2024), 01, Seite 31-39  |h Online-Ressource  |w (DE-627)324742185  |w (DE-600)2030152-2  |w (DE-576)098546333  |x 2567-5761  |7 nnas  |a Pathophysiology of trauma-induced coagulopathy 
773 1 8 |g volume:44  |g year:2024  |g number:01  |g pages:31-39  |g extent:9  |a Pathophysiology of trauma-induced coagulopathy 
856 4 0 |u https://doi.org/10.1055/a-2215-8936  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u http://www.thieme-connect.de/DOI/DOI?10.1055/a-2215-8936  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20240725 
993 |a Article 
994 |a 2024 
998 |g 1038428327  |a Schmitt, Felix  |m 1038428327:Schmitt, Felix  |d 910000  |d 910300  |d 50000  |e 910000PS1038428327  |e 910300PS1038428327  |e 50000PS1038428327  |k 0/910000/  |k 1/910000/910300/  |k 0/50000/  |p 2 
999 |a KXP-PPN1896412262  |e 4557010393 
BIB |a Y 
SER |a journal 
JSO |a {"type":{"bibl":"article-journal","media":"Online-Ressource"},"recId":"1896412262","note":["Gesehen am 25.07.2024","Zusammenfassung in deutscher Sprache"],"language":["eng"],"person":[{"family":"Schöchl","given":"Herbert","role":"aut","roleDisplay":"VerfasserIn","display":"Schöchl, Herbert"},{"family":"Schmitt","display":"Schmitt, Felix","roleDisplay":"VerfasserIn","role":"aut","given":"Felix"},{"family":"Maegele","role":"aut","roleDisplay":"VerfasserIn","given":"Marc","display":"Maegele, Marc"}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"dateIssuedDisp":"1981-","publisher":"Thieme ; Schattauer","dateIssuedKey":"1981","publisherPlace":"Stuttgart ; Stuttgart"}],"language":["ger"],"disp":"Pathophysiology of trauma-induced coagulopathyHämostaseologie","title":[{"subtitle":"Organ der Gesellschaft für Thrombose- und Hämostaseforschung e.V. (GTH) = Progress in haemostasis","title_sort":"Hämostaseologie","title":"Hämostaseologie"}],"id":{"zdb":["2030152-2"],"eki":["324742185"],"issn":["2567-5761"],"doi":["10.1055/s-00034925"]},"corporate":[{"roleDisplay":"Herausgebendes Organ","role":"isb","display":"Gesellschaft für Thrombose- und Hämostaseforschung"}],"titleTranslated":[{"translated":"Progress in haemostasis"}],"pubHistory":["1.1981,1(März) -"],"type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 10.02.2020"],"recId":"324742185","part":{"volume":"44","issue":"01","text":"44(2024), 01, Seite 31-39","year":"2024","extent":"9","pages":"31-39"}}],"id":{"doi":["10.1055/a-2215-8936"],"eki":["1896412262"]},"name":{"displayForm":["Herbert Schöchl, Felix C.F. Schmitt, Marc Maegele"]},"physDesc":[{"extent":"9 S.","noteIll":"Illustrationen"}],"origin":[{"dateIssuedDisp":"28. Februar 2024","dateIssuedKey":"2024"}],"title":[{"title_sort":"Pathophysiology of trauma-induced coagulopathy","title":"Pathophysiology of trauma-induced coagulopathy"}]} 
SRT |a SCHOECHLHEPATHOPHYSI2820 

Similar Items