Neovascularization, vascular mimicry and molecular exchange$tThe imaging of tumorous tissue aggressiveness based on tissue perfusion
Angiogenesis in healthy tissue and within malignant tumors differs on many levels, which may partly be explained by vascular mimicry formation resulting in altered contrast material or different radiopharmaceuticals distributions. Failed remodulation results in changes in the molecular exchange thro...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
June 2023
|
| In: |
European journal of radiology
Year: 2023, Jahrgang: 163, Pages: 1-11 |
| ISSN: | 1872-7727 |
| DOI: | 10.1016/j.ejrad.2023.110797 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ejrad.2023.110797 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0720048X23001110 
|
| Verfasserangaben: | Jiří Ferda, Matthias Frölich, Eva Ferdová, Filip Heidenreich, Radim Charvát, Hynek Mírka |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1896757952 | ||
| 003 | DE-627 | ||
| 005 | 20241205154748.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240729s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ejrad.2023.110797 |2 doi | |
| 035 | |a (DE-627)1896757952 | ||
| 035 | |a (DE-599)KXP1896757952 | ||
| 035 | |a (OCoLC)1475304852 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Ferda, Jiří |e VerfasserIn |0 (DE-588)1337169854 |0 (DE-627)189675919X |4 aut | |
| 245 | 1 | 0 | |a Neovascularization, vascular mimicry and molecular exchange$tThe imaging of tumorous tissue aggressiveness based on tissue perfusion |c Jiří Ferda, Matthias Frölich, Eva Ferdová, Filip Heidenreich, Radim Charvát, Hynek Mírka |
| 264 | 1 | |c June 2023 | |
| 300 | |b Illustrationen | ||
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online verfügbar: 24. März 2023, Artikelversion: 3. April 2023 | ||
| 500 | |a Gesehen am 29.07.2024 | ||
| 520 | |a Angiogenesis in healthy tissue and within malignant tumors differs on many levels, which may partly be explained by vascular mimicry formation resulting in altered contrast material or different radiopharmaceuticals distributions. Failed remodulation results in changes in the molecular exchange through the capillary wall and those consequences affect the behavior of contrast agents and radiopharmaceuticals. One of the most indicative signs of malignant tissue is the increased permeability and the faster molecular exchange that occurs between the extracellular and intravascular spaces. Dynamic imaging can help to assess the changed microenvironment. The fast-distribution of molecules reflects newly developed conditions in blood-flow redistribution inside a tumor and within the affected organ during the early stages of tumor formation. Tumor development, as well as aggressiveness, can be assessed based on the change to the vascular bed development, the level of molecular exchange within the tissue, and/or indicative distribution within the organ. The study of the vascular network organization and its impact on the distribution of molecules is important to our understanding of the image pattern in several imaging methods, which in turn influences our interpretation of the findings. A hybrid imaging approach (including PET/MRI) allows the quantification of vascularization and/or its pathophysiological impressions in structural and metabolic images. It might optimize the evaluation of the pretreatment imaging, as well as help assess the effect of therapy targeting neovascularization; antiVEGF drugs and embolization-based therapies, for example. | ||
| 650 | 4 | |a Neovascularization | |
| 650 | 4 | |a Perfusion imaging | |
| 650 | 4 | |a Pharmacokinetics | |
| 650 | 4 | |a Vascular mimicry | |
| 700 | 1 | |a Froelich, Matthias F. |d 1991- |e VerfasserIn |0 (DE-588)1170833756 |0 (DE-627)1040131557 |0 (DE-576)512678359 |4 aut | |
| 700 | 1 | |a Ferdová, Eva |e VerfasserIn |4 aut | |
| 700 | 1 | |a Heidenreich, Filip |e VerfasserIn |4 aut | |
| 700 | 1 | |a Charvát, Radim |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mírka, Hynek |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European journal of radiology |d Amsterdam [u.a.] : Elsevier Science, 1990 |g 163(2023), Artikel-ID 110797, Seite 1-11 |h Online-Ressource |w (DE-627)32044483X |w (DE-600)2005350-2 |w (DE-576)099718138 |x 1872-7727 |7 nnas |a Neovascularization, vascular mimicry and molecular exchange$tThe imaging of tumorous tissue aggressiveness based on tissue perfusion |
| 773 | 1 | 8 | |g volume:163 |g year:2023 |g elocationid:110797 |g pages:1-11 |g extent:11 |a Neovascularization, vascular mimicry and molecular exchange$tThe imaging of tumorous tissue aggressiveness based on tissue perfusion |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.ejrad.2023.110797 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0720048X23001110 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20240729 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 1170833756 |a Froelich, Matthias F. |m 1170833756:Froelich, Matthias F. |d 60000 |d 62900 |d 60000 |e 60000PF1170833756 |e 62900PF1170833756 |e 60000PF1170833756 |k 0/60000/ |k 1/60000/62900/ |k 0/60000/ |p 2 | ||
| 999 | |a KXP-PPN1896757952 |e 4559848130 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Online verfügbar: 24. März 2023, Artikelversion: 3. April 2023","Gesehen am 29.07.2024"],"recId":"1896757952","id":{"doi":["10.1016/j.ejrad.2023.110797"],"eki":["1896757952"]},"title":[{"title":"Neovascularization, vascular mimicry and molecular exchange$tThe imaging of tumorous tissue aggressiveness based on tissue perfusion","title_sort":"Neovascularization, vascular mimicry and molecular exchange$tThe imaging of tumorous tissue aggressiveness based on tissue perfusion"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"origin":[{"dateIssuedDisp":"June 2023","dateIssuedKey":"2023"}],"language":["eng"],"relHost":[{"recId":"32044483X","pubHistory":["Nachgewiesen 10.1990 -"],"titleAlt":[{"title":"EJR"}],"language":["eng"],"type":{"media":"Online-Ressource","bibl":"periodical"},"origin":[{"publisherPlace":"Amsterdam [u.a.]","dateIssuedKey":"1990","dateIssuedDisp":"1990-","publisher":"Elsevier Science"}],"part":{"volume":"163","text":"163(2023), Artikel-ID 110797, Seite 1-11","pages":"1-11","year":"2023","extent":"11"},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"subtitle":"EJR","title":"European journal of radiology","title_sort":"European journal of radiology"}],"id":{"eki":["32044483X"],"zdb":["2005350-2"],"issn":["1872-7727"]},"disp":"Neovascularization, vascular mimicry and molecular exchange$tThe imaging of tumorous tissue aggressiveness based on tissue perfusionEuropean journal of radiology","note":["Gesehen am 05.02.20"]}],"name":{"displayForm":["Jiří Ferda, Matthias Frölich, Eva Ferdová, Filip Heidenreich, Radim Charvát, Hynek Mírka"]},"person":[{"family":"Ferda","roleDisplay":"VerfasserIn","role":"aut","display":"Ferda, Jiří","given":"Jiří"},{"family":"Froelich","roleDisplay":"VerfasserIn","given":"Matthias F.","role":"aut","display":"Froelich, Matthias F."},{"role":"aut","display":"Ferdová, Eva","given":"Eva","family":"Ferdová","roleDisplay":"VerfasserIn"},{"family":"Heidenreich","roleDisplay":"VerfasserIn","role":"aut","display":"Heidenreich, Filip","given":"Filip"},{"family":"Charvát","roleDisplay":"VerfasserIn","role":"aut","display":"Charvát, Radim","given":"Radim"},{"given":"Hynek","display":"Mírka, Hynek","role":"aut","roleDisplay":"VerfasserIn","family":"Mírka"}],"physDesc":[{"extent":"11 S.","noteIll":"Illustrationen"}]} | ||
| SRT | |a FERDAJIRIFNEOVASCULA2023 | ||