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CEMIP (HYBID, KIAA1199): structure, function and expression in health and disease: viewpoint

CEMIP (cell migration-inducing protein), also known as KIAA1199 or HYBID, is a protein involved in the depolymerisation of hyaluronic acid (HA), a major glycosaminoglycan component of the extracellular matrix. CEMIP was originally described in patients affected by nonsyndromic hearing loss and has s...

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Bibliographische Detailangaben
Hauptverfasser: Spataro, Sofia (VerfasserIn) , Guerra, Concetta (VerfasserIn) , Cavalli, Andrea (VerfasserIn) , Sgrignani, Jacopo (VerfasserIn) , Sleeman, Jonathan P. (VerfasserIn) , Poulain, Lina (VerfasserIn) , Boland, Andreas (VerfasserIn) , Scapozza, Leonardo (VerfasserIn) , Moll, Solange (VerfasserIn) , Prunotto, Marco (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: August 2023
In: The FEBS journal
Year: 2023, Jahrgang: 290, Heft: 16, Pages: 3946-3962
ISSN:1742-4658
DOI:10.1111/febs.16600
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1111/febs.16600
Verlag, kostenfrei, Volltext: http://onlinelibrary.wiley.com/doi/abs/10.1111/febs.16600
Volltext
Verfasserangaben:Sofia Spataro, Concetta Guerra, Andrea Cavalli, Jacopo Sgrignani, Jonathan Sleeman, Lina Poulain, Andreas Boland, Leonardo Scapozza, Solange Moll and Marco Prunotto
Beschreibung
Zusammenfassung:CEMIP (cell migration-inducing protein), also known as KIAA1199 or HYBID, is a protein involved in the depolymerisation of hyaluronic acid (HA), a major glycosaminoglycan component of the extracellular matrix. CEMIP was originally described in patients affected by nonsyndromic hearing loss and has subsequently been shown to play a key role in tumour initiation and progression, as well as arthritis, atherosclerosis and idiopathic pulmonary fibrosis. Despite the vast literature associating CEMIP with these diseases, its biology remains elusive. The present review article summarises all the major scientific evidence regarding its structure, function, role and expression, and attempts to cast light on a protein that modulates EMT, fibrosis and tissue inflammation, an unmet key aspect in several inflammatory disease conditions.
Beschreibung:Erstmals online veröffentlicht: 23. August 2022
Gesehen am 29.07.2024
Beschreibung:Online Resource
ISSN:1742-4658
DOI:10.1111/febs.16600

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