Association between resting-state connectivity patterns in the defensive system network and treatment response in spider phobia - a replication approach
Although highly effective on average, exposure-based treatments do not work equally well for all patients with anxiety disorders. The identification of pre-treatment response-predicting patient characteristics may enable patient stratification. Preliminary research highlights the relevance of inhibi...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
07 March 2024
|
| In: |
Translational Psychiatry
Year: 2024, Jahrgang: 14, Pages: 1-12 |
| ISSN: | 2158-3188 |
| DOI: | 10.1038/s41398-024-02799-x |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41398-024-02799-x Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41398-024-02799-x 
|
| Verfasserangaben: | Elisabeth J. Leehr, Fabian R. Seeger, Joscha Böhnlein, Bettina Gathmann, Thomas Straube, Kati Roesmann, Markus Junghöfer, Hanna Schwarzmeier, Niklas Siminski, Martin J. Herrmann, Till Langhammer, Janik Goltermann, Dominik Grotegerd, Susanne Meinert, Nils R. Winter, Udo Dannlowski and Ulrike Lueken |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1896920918 | ||
| 003 | DE-627 | ||
| 005 | 20250118002849.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240730s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41398-024-02799-x |2 doi | |
| 035 | |a (DE-627)1896920918 | ||
| 035 | |a (DE-599)KXP1896920918 | ||
| 035 | |a (OCoLC)1475305105 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Leehr, Elisabeth Johanna |e VerfasserIn |0 (DE-588)1091595925 |0 (DE-627)852487118 |0 (DE-576)461743302 |4 aut | |
| 245 | 1 | 0 | |a Association between resting-state connectivity patterns in the defensive system network and treatment response in spider phobia - a replication approach |c Elisabeth J. Leehr, Fabian R. Seeger, Joscha Böhnlein, Bettina Gathmann, Thomas Straube, Kati Roesmann, Markus Junghöfer, Hanna Schwarzmeier, Niklas Siminski, Martin J. Herrmann, Till Langhammer, Janik Goltermann, Dominik Grotegerd, Susanne Meinert, Nils R. Winter, Udo Dannlowski and Ulrike Lueken |
| 264 | 1 | |c 07 March 2024 | |
| 300 | |b Illustrationen | ||
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 30.07.2024 | ||
| 520 | |a Although highly effective on average, exposure-based treatments do not work equally well for all patients with anxiety disorders. The identification of pre-treatment response-predicting patient characteristics may enable patient stratification. Preliminary research highlights the relevance of inhibitory fronto-limbic networks as such. We aimed to identify pre-treatment neural signatures differing between exposure treatment responders and non-responders in spider phobia and to validate results through rigorous replication. Data of a bi-centric intervention study comprised clinical phenotyping and pre-treatment resting-state functional connectivity (rsFC) data of n = 79 patients with spider phobia (discovery sample) and n = 69 patients (replication sample). RsFC data analyses were accomplished using the Matlab-based CONN-toolbox with harmonized analyses protocols at both sites. Treatment response was defined by a reduction of >30% symptom severity from pre- to post-treatment (Spider Phobia Questionnaire Score, primary outcome). Secondary outcome was defined by a reduction of >50% in a Behavioral Avoidance Test (BAT). Mean within-session fear reduction functioned as a process measure for exposure. Compared to non-responders and pre-treatment, results in the discovery sample seemed to indicate that responders exhibited stronger negative connectivity between frontal and limbic structures and were characterized by heightened connectivity between the amygdala and ventral visual pathway regions. Patients exhibiting high within-session fear reduction showed stronger excitatory connectivity within the prefrontal cortex than patients with low within-session fear reduction. Whereas these results could be replicated by another team using the same data (cross-team replication), cross-site replication of the discovery sample findings in the independent replication sample was unsuccessful. Results seem to support negative fronto-limbic connectivity as promising ingredient to enhance response rates in specific phobia but lack sufficient replication. Further research is needed to obtain a valid basis for clinical decision-making and the development of individually tailored treatment options. Notably, future studies should regularly include replication approaches in their protocols. | ||
| 650 | 4 | |a Biomarkers | |
| 650 | 4 | |a Predictive markers | |
| 700 | 1 | |a Seeger, Fabian R. |d 1993- |e VerfasserIn |0 (DE-588)1252369581 |0 (DE-627)1793531412 |4 aut | |
| 700 | 1 | |a Böhnlein, Joscha |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gathmann, Bettina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Straube, Thomas |e VerfasserIn |4 aut | |
| 700 | 1 | |8 1\p |a Roesmann, Kati |d 1984- |e VerfasserIn |0 (DE-588)1017246645 |0 (DE-627)676284248 |0 (DE-576)353377902 |4 aut | |
| 700 | 1 | |a Junghöfer, Markus |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schwarzmeier, Hanna |e VerfasserIn |4 aut | |
| 700 | 1 | |a Siminski, Niklas |e VerfasserIn |4 aut | |
| 700 | 1 | |8 2\p |a Herrmann, Martin J. |d 1970- |e VerfasserIn |0 (DE-588)129125113 |0 (DE-627)390017035 |0 (DE-576)297506234 |4 aut | |
| 700 | 1 | |a Langhammer, Till |e VerfasserIn |4 aut | |
| 700 | 1 | |a Goltermann, Janik |e VerfasserIn |4 aut | |
| 700 | 1 | |8 3\p |a Grotegerd, Dominik |d 1981- |e VerfasserIn |0 (DE-588)1082401595 |0 (DE-627)847460649 |0 (DE-576)455406669 |4 aut | |
| 700 | 1 | |8 4\p |a Meinert, Susanne L. |d 1992- |e VerfasserIn |0 (DE-588)1270228730 |0 (DE-627)1818927845 |4 aut | |
| 700 | 1 | |8 5\p |a Winter, Nils Ralf |d 1991- |e VerfasserIn |0 (DE-588)1305556089 |0 (DE-627)1861153651 |4 aut | |
| 700 | 1 | |8 6\p |a Dannlowski, Udo |d 1976- |e VerfasserIn |0 (DE-588)133239977 |0 (DE-627)539309818 |0 (DE-576)299718077 |4 aut | |
| 700 | 1 | |a Lueken, Ulrike |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Translational Psychiatry |d London : Nature Publishing Group, 2011 |g 14(2024), Artikel-ID 137, Seite 1-12 |h Online-Ressource |w (DE-627)660807378 |w (DE-600)2609311-X |w (DE-576)345003462 |x 2158-3188 |7 nnas |a Association between resting-state connectivity patterns in the defensive system network and treatment response in spider phobia - a replication approach |
| 773 | 1 | 8 | |g volume:14 |g year:2024 |g elocationid:137 |g pages:1-12 |g extent:12 |a Association between resting-state connectivity patterns in the defensive system network and treatment response in spider phobia - a replication approach |
| 856 | 4 | 0 | |u https://doi.org/10.1038/s41398-024-02799-x |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/s41398-024-02799-x |x Verlag |z kostenfrei |3 Volltext |
| 883 | |8 1\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 2\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 3\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 4\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 5\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 6\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 951 | |a AR | ||
| 992 | |a 20240730 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 1252369581 |a Seeger, Fabian R. |m 1252369581:Seeger, Fabian R. |d 910000 |d 910500 |e 910000PS1252369581 |e 910500PS1252369581 |k 0/910000/ |k 1/910000/910500/ |p 2 | ||
| 999 | |a KXP-PPN1896920918 |e 4560131937 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedKey":"2024","dateIssuedDisp":"07 March 2024"}],"id":{"eki":["1896920918"],"doi":["10.1038/s41398-024-02799-x"]},"relHost":[{"title":[{"title_sort":"Translational Psychiatry","title":"Translational Psychiatry"}],"disp":"Association between resting-state connectivity patterns in the defensive system network and treatment response in spider phobia - a replication approachTranslational Psychiatry","type":{"bibl":"periodical","media":"Online-Ressource"},"pubHistory":["1.2011 -"],"note":["Gesehen am 17.05.11"],"language":["eng"],"recId":"660807378","physDesc":[{"extent":"Online-Ressource"}],"part":{"extent":"12","year":"2024","text":"14(2024), Artikel-ID 137, Seite 1-12","pages":"1-12","volume":"14"},"origin":[{"publisherPlace":"London","publisher":"Nature Publishing Group","dateIssuedKey":"2011","dateIssuedDisp":"2011-"}],"id":{"eki":["660807378"],"issn":["2158-3188"],"zdb":["2609311-X"]}}],"recId":"1896920918","language":["eng"],"physDesc":[{"extent":"12 S.","noteIll":"Illustrationen"}],"person":[{"roleDisplay":"VerfasserIn","role":"aut","display":"Leehr, Elisabeth Johanna","family":"Leehr","given":"Elisabeth Johanna"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Seeger, Fabian R.","family":"Seeger","given":"Fabian R."},{"role":"aut","roleDisplay":"VerfasserIn","display":"Böhnlein, Joscha","family":"Böhnlein","given":"Joscha"},{"family":"Gathmann","given":"Bettina","roleDisplay":"VerfasserIn","role":"aut","display":"Gathmann, Bettina"},{"family":"Straube","given":"Thomas","role":"aut","roleDisplay":"VerfasserIn","display":"Straube, Thomas"},{"display":"Roesmann, Kati","roleDisplay":"VerfasserIn","role":"aut","given":"Kati","family":"Roesmann"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Junghöfer, Markus","family":"Junghöfer","given":"Markus"},{"given":"Hanna","family":"Schwarzmeier","display":"Schwarzmeier, Hanna","role":"aut","roleDisplay":"VerfasserIn"},{"given":"Niklas","family":"Siminski","role":"aut","roleDisplay":"VerfasserIn","display":"Siminski, Niklas"},{"roleDisplay":"VerfasserIn","role":"aut","display":"Herrmann, Martin J.","family":"Herrmann","given":"Martin J."},{"family":"Langhammer","given":"Till","role":"aut","roleDisplay":"VerfasserIn","display":"Langhammer, Till"},{"family":"Goltermann","given":"Janik","roleDisplay":"VerfasserIn","role":"aut","display":"Goltermann, Janik"},{"roleDisplay":"VerfasserIn","role":"aut","display":"Grotegerd, Dominik","family":"Grotegerd","given":"Dominik"},{"family":"Meinert","given":"Susanne L.","display":"Meinert, Susanne L.","role":"aut","roleDisplay":"VerfasserIn"},{"given":"Nils Ralf","family":"Winter","display":"Winter, Nils Ralf","role":"aut","roleDisplay":"VerfasserIn"},{"family":"Dannlowski","given":"Udo","role":"aut","roleDisplay":"VerfasserIn","display":"Dannlowski, Udo"},{"given":"Ulrike","family":"Lueken","display":"Lueken, Ulrike","role":"aut","roleDisplay":"VerfasserIn"}],"note":["Gesehen am 30.07.2024"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"title":[{"title":"Association between resting-state connectivity patterns in the defensive system network and treatment response in spider phobia - a replication approach","title_sort":"Association between resting-state connectivity patterns in the defensive system network and treatment response in spider phobia - a replication approach"}],"name":{"displayForm":["Elisabeth J. Leehr, Fabian R. Seeger, Joscha Böhnlein, Bettina Gathmann, Thomas Straube, Kati Roesmann, Markus Junghöfer, Hanna Schwarzmeier, Niklas Siminski, Martin J. Herrmann, Till Langhammer, Janik Goltermann, Dominik Grotegerd, Susanne Meinert, Nils R. Winter, Udo Dannlowski and Ulrike Lueken"]}} | ||
| SRT | |a LEEHRELISAASSOCIATIO0720 | ||