Region-specific rnhancement of c-fos expression by combined treatment with NMDA receptor agonists and antagonists with antidepressant potential: brief report
Rapastinel, formerly Glyx-13, is a novel positive allosteric modulator of the N-methyl-D-aspartate-receptor (NMDAR) that counteracts psychotomimetic actions of NMDAR antagonists. We set out to evaluate the effect of rapastinel alone or in combination with the global and GluN2B subunit-specific NMDAR...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
November 2022
|
| In: |
The international journal of neuropsychopharmacology
Year: 2022, Jahrgang: 25, Heft: 11, Pages: 946-950 |
| ISSN: | 1469-5111 |
| DOI: | 10.1093/ijnp/pyac051 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/ijnp/pyac051 Verlag, lizenzpflichtig, Volltext: https://academic.oup.com/ijnp/article/25/11/946/6668855?login=true 
|
| Verfasserangaben: | Andrei-Nicolae Vasilescu, Natascha Pfeiffer, Federica Terraneo, Marco Andrea Riva, Undine E. Lang, Dragos Inta, Peter Gass |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1896927106 | ||
| 003 | DE-627 | ||
| 005 | 20241205155214.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240730s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/ijnp/pyac051 |2 doi | |
| 035 | |a (DE-627)1896927106 | ||
| 035 | |a (DE-599)KXP1896927106 | ||
| 035 | |a (OCoLC)1475305160 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Vasilescu, Andrei-Nicolae |d 1988- |e VerfasserIn |0 (DE-588)115863997X |0 (DE-627)1020630876 |0 (DE-576)504274333 |4 aut | |
| 245 | 1 | 0 | |a Region-specific rnhancement of c-fos expression by combined treatment with NMDA receptor agonists and antagonists with antidepressant potential |b brief report |c Andrei-Nicolae Vasilescu, Natascha Pfeiffer, Federica Terraneo, Marco Andrea Riva, Undine E. Lang, Dragos Inta, Peter Gass |
| 264 | 1 | |c November 2022 | |
| 300 | |a 5 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Artikel veröffentlicht: 17. August 2022 | ||
| 500 | |a Gesehen am 30.07.2024 | ||
| 520 | |a Rapastinel, formerly Glyx-13, is a novel positive allosteric modulator of the N-methyl-D-aspartate-receptor (NMDAR) that counteracts psychotomimetic actions of NMDAR antagonists. We set out to evaluate the effect of rapastinel alone or in combination with the global and GluN2B subunit-specific NMDAR antagonists MK-801 and Ro25-6981, respectively, on neuronal activation in relevant regions using c-fos brain mapping. Whereas rapastinel alone did not trigger significant c-fos expression beyond the prelimbic cortex, it strongly increased the c-fos expression induced by MK-801 in hippocampal, cingulate, and retrosplenial areas. Similar results were obtained when rapastinel was replaced by D-cycloserine. Our results reveal new interactions at network level between NMDAR modulators with possible implications regarding their therapeutic effects. | ||
| 700 | 1 | |a Pfeiffer, Natascha |e VerfasserIn |4 aut | |
| 700 | 1 | |a Terraneo, Federica |e VerfasserIn |4 aut | |
| 700 | 1 | |a Riva, Marco Andrea |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lang, Undine E |e VerfasserIn |4 aut | |
| 700 | 1 | |a Inta, Dragos |d 1972- |e VerfasserIn |0 (DE-588)133064980 |0 (DE-627)533317088 |0 (DE-576)299599701 |4 aut | |
| 700 | 1 | |a Gass, Peter |d 1963- |e VerfasserIn |0 (DE-588)13015945X |0 (DE-627)492009694 |0 (DE-576)298033771 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The international journal of neuropsychopharmacology |d Oxford : Oxford Univ. Press, 1998 |g 25(2022), 11 vom: Nov., Seite 946-950 |h Online-Ressource |w (DE-627)30671339X |w (DE-600)1501053-3 |w (DE-576)306828731 |x 1469-5111 |7 nnas |a Region-specific rnhancement of c-fos expression by combined treatment with NMDA receptor agonists and antagonists with antidepressant potential brief report |
| 773 | 1 | 8 | |g volume:25 |g year:2022 |g number:11 |g month:11 |g pages:946-950 |g extent:5 |a Region-specific rnhancement of c-fos expression by combined treatment with NMDA receptor agonists and antagonists with antidepressant potential brief report |
| 856 | 4 | 0 | |u https://doi.org/10.1093/ijnp/pyac051 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://academic.oup.com/ijnp/article/25/11/946/6668855?login=true |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20240730 | ||
| 993 | |a Article | ||
| 994 | |a 2022 | ||
| 998 | |g 13015945X |a Gass, Peter |m 13015945X:Gass, Peter |d 60000 |e 60000PG13015945X |k 0/60000/ |p 7 |y j | ||
| 998 | |g 133064980 |a Inta, Dragos |m 133064980:Inta, Dragos |d 60000 |e 60000PI133064980 |k 0/60000/ |p 6 | ||
| 998 | |g 115863997X |a Vasilescu, Andrei-Nicolae |m 115863997X:Vasilescu, Andrei-Nicolae |d 60000 |e 60000PV115863997X |k 0/60000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1896927106 |e 4560241902 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Region-specific rnhancement of c-fos expression by combined treatment with NMDA receptor agonists and antagonists with antidepressant potential brief reportThe international journal of neuropsychopharmacology","note":["Gesehen am 31.03.15"],"language":["eng"],"recId":"30671339X","pubHistory":["1.1998 -"],"part":{"extent":"5","volume":"25","text":"25(2022), 11 vom: Nov., Seite 946-950","pages":"946-950","issue":"11","year":"2022"},"title":[{"subtitle":"the official scientific journal of the Collegium Internationale Neuro-Psychopharmacologicum (CINP)","title":"The international journal of neuropsychopharmacology","title_sort":"international journal of neuropsychopharmacology"}],"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"publisherPlace":"Oxford ; Cambridge","dateIssuedKey":"1998","publisher":"Oxford Univ. Press ; Cambridge Univ. Press","dateIssuedDisp":"1998-"}],"id":{"eki":["30671339X"],"zdb":["1501053-3"],"issn":["1469-5111"]}}],"physDesc":[{"extent":"5 S."}],"name":{"displayForm":["Andrei-Nicolae Vasilescu, Natascha Pfeiffer, Federica Terraneo, Marco Andrea Riva, Undine E. Lang, Dragos Inta, Peter Gass"]},"id":{"eki":["1896927106"],"doi":["10.1093/ijnp/pyac051"]},"origin":[{"dateIssuedKey":"2022","dateIssuedDisp":"November 2022"}],"language":["eng"],"recId":"1896927106","type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Artikel veröffentlicht: 17. August 2022","Gesehen am 30.07.2024"],"person":[{"family":"Vasilescu","given":"Andrei-Nicolae","display":"Vasilescu, Andrei-Nicolae","roleDisplay":"VerfasserIn","role":"aut"},{"display":"Pfeiffer, Natascha","roleDisplay":"VerfasserIn","role":"aut","family":"Pfeiffer","given":"Natascha"},{"family":"Terraneo","given":"Federica","roleDisplay":"VerfasserIn","display":"Terraneo, Federica","role":"aut"},{"display":"Riva, Marco Andrea","roleDisplay":"VerfasserIn","role":"aut","family":"Riva","given":"Marco Andrea"},{"given":"Undine E","family":"Lang","role":"aut","roleDisplay":"VerfasserIn","display":"Lang, Undine E"},{"role":"aut","display":"Inta, Dragos","roleDisplay":"VerfasserIn","given":"Dragos","family":"Inta"},{"given":"Peter","family":"Gass","role":"aut","display":"Gass, Peter","roleDisplay":"VerfasserIn"}],"title":[{"title_sort":"Region-specific rnhancement of c-fos expression by combined treatment with NMDA receptor agonists and antagonists with antidepressant potential","title":"Region-specific rnhancement of c-fos expression by combined treatment with NMDA receptor agonists and antagonists with antidepressant potential","subtitle":"brief report"}]} | ||
| SRT | |a VASILESCUAREGIONSPEC2022 | ||