Liprin-α proteins are master regulators of human presynapse assembly
The formation of mammalian synapses entails the precise alignment of presynaptic release sites with postsynaptic receptors but how nascent cell-cell contacts translate into assembly of presynaptic specializations remains unclear. Guided by pioneering work in invertebrates, we hypothesized that in ma...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
12 March 2024
|
| In: |
Nature neuroscience
Year: 2024, Volume: 27, Issue: 4, Pages: 629-642, [1-22] |
| ISSN: | 1546-1726 |
| DOI: | 10.1038/s41593-024-01592-9 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41593-024-01592-9 Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41593-024-01592-9 
|
| Author Notes: | Berta Marcó de la Cruz, Joaquín Campos, Angela Molinaro, Xingqiao Xie, Gaowei Jin, Zhiyi Wei, Claudio Acuna & Fredrik H. Sterky |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1897200226 | ||
| 003 | DE-627 | ||
| 005 | 20250908164517.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240731s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41593-024-01592-9 |2 doi | |
| 035 | |a (DE-627)1897200226 | ||
| 035 | |a (DE-599)KXP1897200226 | ||
| 035 | |a (OCoLC)1475305211 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Marcó de la Cruz, Berta |e VerfasserIn |0 (DE-588)1337478261 |0 (DE-627)1897200684 |4 aut | |
| 245 | 1 | 0 | |a Liprin-α proteins are master regulators of human presynapse assembly |c Berta Marcó de la Cruz, Joaquín Campos, Angela Molinaro, Xingqiao Xie, Gaowei Jin, Zhiyi Wei, Claudio Acuna & Fredrik H. Sterky |
| 246 | 3 | 3 | |a Liprin-alpha proteins are master regulators of human presynapse assembly |
| 264 | 1 | |c 12 March 2024 | |
| 300 | |b Illustrationen | ||
| 300 | |a 35 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 31.07.2024 | ||
| 520 | |a The formation of mammalian synapses entails the precise alignment of presynaptic release sites with postsynaptic receptors but how nascent cell-cell contacts translate into assembly of presynaptic specializations remains unclear. Guided by pioneering work in invertebrates, we hypothesized that in mammalian synapses, liprin-α proteins directly link trans-synaptic initial contacts to downstream steps. Here we show that, in human neurons lacking all four liprin-α isoforms, nascent synaptic contacts are formed but recruitment of active zone components and accumulation of synaptic vesicles is blocked, resulting in ‘empty’ boutons and loss of synaptic transmission. Interactions with presynaptic cell adhesion molecules of either the LAR-RPTP family or neurexins via CASK are required to localize liprin-α to nascent synaptic sites. Liprin-α subsequently recruits presynaptic components via a direct interaction with ELKS proteins. Thus, assembly of human presynaptic terminals is governed by a hierarchical sequence of events in which the recruitment of liprin-α proteins by presynaptic cell adhesion molecules is a critical initial step. | ||
| 650 | 4 | |a Cellular neuroscience | |
| 650 | 4 | |a Molecular neuroscience | |
| 650 | 4 | |a Synaptic development | |
| 700 | 1 | |a Campos, Joaquín |d 1992- |e VerfasserIn |0 (DE-588)1305083334 |0 (DE-627)1860855075 |4 aut | |
| 700 | 1 | |a Molinaro, Angela |e VerfasserIn |4 aut | |
| 700 | 1 | |a Xie, Xingqiao |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jin, Gaowei |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wei, Zhiyi |e VerfasserIn |4 aut | |
| 700 | 1 | |a Acuna Goycolea, Claudio |d 1977- |e VerfasserIn |0 (DE-588)1194112714 |0 (DE-627)1675912173 |4 aut | |
| 700 | 1 | |a Sterky, Fredrik H. |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nature neuroscience |d New York, NY : Nature America, 1998 |g 27(2024), 4, Seite 629-642, [1-22] |h Online-Ressource |w (DE-627)303393823 |w (DE-600)1494955-6 |w (DE-576)080887201 |x 1546-1726 |7 nnas |a Liprin-α proteins are master regulators of human presynapse assembly |
| 773 | 1 | 8 | |g volume:27 |g year:2024 |g number:4 |g pages:629-642, [1-22] |g extent:35 |a Liprin-α proteins are master regulators of human presynapse assembly |
| 856 | 4 | 0 | |u https://doi.org/10.1038/s41593-024-01592-9 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/s41593-024-01592-9 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20240731 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 1194112714 |a Acuna Goycolea, Claudio |m 1194112714:Acuna Goycolea, Claudio |d 50000 |d 53100 |e 50000PA1194112714 |e 53100PA1194112714 |k 0/50000/ |k 1/50000/53100/ |p 7 | ||
| 998 | |g 1305083334 |a Campos, Joaquín |m 1305083334:Campos, Joaquín |d 140000 |e 140000PC1305083334 |k 0/140000/ |p 2 | ||
| 999 | |a KXP-PPN1897200226 |e 4561125752 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 31.07.2024"],"id":{"doi":["10.1038/s41593-024-01592-9"],"eki":["1897200226"]},"physDesc":[{"extent":"35 S.","noteIll":"Illustrationen"}],"relHost":[{"pubHistory":["1.1998 -"],"type":{"bibl":"periodical","media":"Online-Ressource"},"part":{"year":"2024","volume":"27","extent":"35","text":"27(2024), 4, Seite 629-642, [1-22]","issue":"4","pages":"629-642, [1-22]"},"id":{"issn":["1546-1726"],"zdb":["1494955-6"],"eki":["303393823"]},"physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 02.03.05"],"titleAlt":[{"title":"Neuroscience"}],"title":[{"title":"Nature neuroscience","title_sort":"Nature neuroscience"}],"language":["eng"],"recId":"303393823","origin":[{"publisher":"Nature America","dateIssuedDisp":"1998-","publisherPlace":"New York, NY","dateIssuedKey":"1998"}],"disp":"Liprin-α proteins are master regulators of human presynapse assemblyNature neuroscience"}],"title":[{"title":"Liprin-α proteins are master regulators of human presynapse assembly","title_sort":"Liprin-α proteins are master regulators of human presynapse assembly"}],"origin":[{"dateIssuedDisp":"12 March 2024","dateIssuedKey":"2024"}],"recId":"1897200226","person":[{"roleDisplay":"VerfasserIn","display":"Marcó de la Cruz, Berta","family":"Marcó de la Cruz","given":"Berta","role":"aut"},{"roleDisplay":"VerfasserIn","role":"aut","given":"Joaquín","display":"Campos, Joaquín","family":"Campos"},{"roleDisplay":"VerfasserIn","family":"Molinaro","display":"Molinaro, Angela","role":"aut","given":"Angela"},{"roleDisplay":"VerfasserIn","given":"Xingqiao","role":"aut","display":"Xie, Xingqiao","family":"Xie"},{"display":"Jin, Gaowei","family":"Jin","given":"Gaowei","role":"aut","roleDisplay":"VerfasserIn"},{"display":"Wei, Zhiyi","family":"Wei","role":"aut","given":"Zhiyi","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","family":"Acuna Goycolea","display":"Acuna Goycolea, Claudio","given":"Claudio","role":"aut"},{"family":"Sterky","display":"Sterky, Fredrik H.","role":"aut","given":"Fredrik H.","roleDisplay":"VerfasserIn"}],"language":["eng"],"name":{"displayForm":["Berta Marcó de la Cruz, Joaquín Campos, Angela Molinaro, Xingqiao Xie, Gaowei Jin, Zhiyi Wei, Claudio Acuna & Fredrik H. Sterky"]},"titleAlt":[{"title":"Liprin-alpha proteins are master regulators of human presynapse assembly"}]} | ||
| SRT | |a MARCODELACLIPRINPROT1220 | ||