Solitary pulmonary metastases at first recurrence of osteosarcoma: presentation, treatment, and survival of 219 patients of the Cooperative Osteosarcoma Study Group
Background To evaluate patient and tumour characteristics, treatment and their impact on survival in patients with a solitary pulmonary metastasis at first relapse of high-grade osteosarcoma. Procedure Two-hundred and nineteen consecutive patients who had achieved a complete surgical remission and t...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
September 2023
|
| In: |
Cancer medicine
Year: 2023, Jahrgang: 12, Heft: 17, Pages: 18219-18234 |
| ISSN: | 2045-7634 |
| DOI: | 10.1002/cam4.6409 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1002/cam4.6409 Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/cam4.6409 
|
| Verfasserangaben: | Vanessa L. Mettmann, Daniel Baumhoer, Stefan S. Bielack, Claudia Blattmann, Godehard Friedel, Thekla von Kalle, Leo Kager, Matthias Kevric, Michaela Nathrath, Benjamin Sorg, Matthias Dürken, Stefanie Hecker-Nolting |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1897355319 | ||
| 003 | DE-627 | ||
| 005 | 20241205155829.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240801s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/cam4.6409 |2 doi | |
| 035 | |a (DE-627)1897355319 | ||
| 035 | |a (DE-599)KXP1897355319 | ||
| 035 | |a (OCoLC)1475305353 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Mettmann, Vanessa |d 1993- |e VerfasserIn |0 (DE-588)1324330813 |0 (DE-627)1884180841 |4 aut | |
| 245 | 1 | 0 | |a Solitary pulmonary metastases at first recurrence of osteosarcoma |b presentation, treatment, and survival of 219 patients of the Cooperative Osteosarcoma Study Group |c Vanessa L. Mettmann, Daniel Baumhoer, Stefan S. Bielack, Claudia Blattmann, Godehard Friedel, Thekla von Kalle, Leo Kager, Matthias Kevric, Michaela Nathrath, Benjamin Sorg, Matthias Dürken, Stefanie Hecker-Nolting |
| 264 | 1 | |c September 2023 | |
| 300 | |b Illustrationen | ||
| 300 | |a 16 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online veröffentlicht: 7. August 2023 | ||
| 500 | |a Gesehen am 01.08.2024 | ||
| 520 | |a Background To evaluate patient and tumour characteristics, treatment and their impact on survival in patients with a solitary pulmonary metastasis at first relapse of high-grade osteosarcoma. Procedure Two-hundred and nineteen consecutive patients who had achieved a complete surgical remission and then developed a solitary pulmonary metastasis at first recurrence of high-grade osteosarcoma were retrospectively reviewed. Results Two hundred and three (94.9%) of 214 patients achieved a second complete remission. After a median time from initial diagnosis of osteosarcoma to first relapse of 2.3 years (range, 0.3-18.8 years), actuarial post-relapse overall survival after 2 and 5 years was 72.0% and 51.2%. Post-relapse event-free survival was 39.1% and 31.1%. Median follow-up time was 3.2 years (range, 0.1-29.4 years). A longer time until first relapse and diagnosis due to imaging were positive prognostic factors in uni- and multivariate analyses, as were a second complete surgical remission and, in regard to death, the absence of a subsequent relapse. The use of salvage chemotherapy and radiotherapy were not associated with patient outcomes, nor was the surgical approach (thoracoscopy vs. thoracotomy) nor the exploration (uni- vs. bilateral). Conclusion Approximately half of the patients who experience a solitary pulmonary relapse at first recurrence of osteosarcoma remain alive 5 years after this first relapse. Only one third will remain disease-free. A complete surgical resection of the lesion is essential for long-term survival while relapse chemotherapy does not seem to improve survival. Innovative therapies are required to improve outcomes. | ||
| 650 | 4 | |a osteosarcoma | |
| 650 | 4 | |a pulmonary metastases | |
| 650 | 4 | |a recurrence | |
| 650 | 4 | |a survival | |
| 700 | 1 | |a Baumhoer, Daniel |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bielack, Stefan S. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Blattmann, Claudia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Friedel, Godehard |e VerfasserIn |4 aut | |
| 700 | 1 | |a von Kalle, Thekla |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kager, Leo |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kevric, Matthias |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nathrath, Michaela |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sorg, Benjamin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dürken, Matthias |d 1961- |e VerfasserIn |0 (DE-588)1034398431 |0 (DE-627)745449670 |0 (DE-576)382004787 |4 aut | |
| 700 | 1 | |a Hecker-Nolting, Stefanie |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cancer medicine |d Hoboken, NJ : Wiley, 2012 |g 12(2023), 17 vom: Sept., Seite 18219-18234 |h Online-Ressource |w (DE-627)71860153X |w (DE-600)2659751-2 |w (DE-576)366682164 |x 2045-7634 |7 nnas |a Solitary pulmonary metastases at first recurrence of osteosarcoma presentation, treatment, and survival of 219 patients of the Cooperative Osteosarcoma Study Group |
| 773 | 1 | 8 | |g volume:12 |g year:2023 |g number:17 |g month:09 |g pages:18219-18234 |g extent:16 |a Solitary pulmonary metastases at first recurrence of osteosarcoma presentation, treatment, and survival of 219 patients of the Cooperative Osteosarcoma Study Group |
| 856 | 4 | 0 | |u https://doi.org/10.1002/cam4.6409 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1002/cam4.6409 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20240801 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 1034398431 |a Dürken, Matthias |m 1034398431:Dürken, Matthias |d 60000 |e 60000PD1034398431 |k 0/60000/ |p 11 | ||
| 998 | |g 1324330813 |a Mettmann, Vanessa |m 1324330813:Mettmann, Vanessa |d 60000 |e 60000PM1324330813 |k 0/60000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1897355319 |e 4561690964 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"subtitle":"presentation, treatment, and survival of 219 patients of the Cooperative Osteosarcoma Study Group","title_sort":"Solitary pulmonary metastases at first recurrence of osteosarcoma","title":"Solitary pulmonary metastases at first recurrence of osteosarcoma"}],"name":{"displayForm":["Vanessa L. Mettmann, Daniel Baumhoer, Stefan S. Bielack, Claudia Blattmann, Godehard Friedel, Thekla von Kalle, Leo Kager, Matthias Kevric, Michaela Nathrath, Benjamin Sorg, Matthias Dürken, Stefanie Hecker-Nolting"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"physDesc":[{"noteIll":"Illustrationen","extent":"16 S."}],"language":["eng"],"recId":"1897355319","note":["Online veröffentlicht: 7. August 2023","Gesehen am 01.08.2024"],"person":[{"role":"aut","roleDisplay":"VerfasserIn","display":"Mettmann, Vanessa","family":"Mettmann","given":"Vanessa"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Baumhoer, Daniel","family":"Baumhoer","given":"Daniel"},{"display":"Bielack, Stefan S.","role":"aut","roleDisplay":"VerfasserIn","family":"Bielack","given":"Stefan S."},{"role":"aut","roleDisplay":"VerfasserIn","display":"Blattmann, Claudia","given":"Claudia","family":"Blattmann"},{"family":"Friedel","given":"Godehard","roleDisplay":"VerfasserIn","role":"aut","display":"Friedel, Godehard"},{"display":"von Kalle, Thekla","roleDisplay":"VerfasserIn","role":"aut","family":"von Kalle","given":"Thekla"},{"family":"Kager","given":"Leo","display":"Kager, Leo","role":"aut","roleDisplay":"VerfasserIn"},{"given":"Matthias","family":"Kevric","display":"Kevric, Matthias","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Michaela","family":"Nathrath","display":"Nathrath, Michaela","role":"aut","roleDisplay":"VerfasserIn"},{"family":"Sorg","given":"Benjamin","display":"Sorg, Benjamin","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Matthias","family":"Dürken","display":"Dürken, Matthias","role":"aut","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","role":"aut","display":"Hecker-Nolting, Stefanie","family":"Hecker-Nolting","given":"Stefanie"}],"id":{"eki":["1897355319"],"doi":["10.1002/cam4.6409"]},"origin":[{"dateIssuedDisp":"September 2023","dateIssuedKey":"2023"}],"relHost":[{"language":["eng"],"recId":"71860153X","physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 07.05.13"],"part":{"text":"12(2023), 17 vom: Sept., Seite 18219-18234","issue":"17","volume":"12","pages":"18219-18234","year":"2023","extent":"16"},"origin":[{"publisherPlace":"Hoboken, NJ","publisher":"Wiley","dateIssuedKey":"2012","dateIssuedDisp":"2012-"}],"id":{"zdb":["2659751-2"],"issn":["2045-7634"],"eki":["71860153X"]},"title":[{"title":"Cancer medicine","title_sort":"Cancer medicine"}],"disp":"Solitary pulmonary metastases at first recurrence of osteosarcoma presentation, treatment, and survival of 219 patients of the Cooperative Osteosarcoma Study GroupCancer medicine","type":{"bibl":"periodical","media":"Online-Ressource"},"pubHistory":["1.2012 -"]}]} | ||
| SRT | |a METTMANNVASOLITARYPU2023 | ||