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High interindividual variability in LDL-cholesterol reductions after inclisiran administration in a real-world multicenter setting in Germany

Low-density lipoprotein cholesterol (LDL-C) is the main therapeutic target in the treatment of hypercholesterolemia. Small interfering RNA (siRNA) inclisiran is a new drug, which targets PCSK9 mRNA in the liver, reducing concentrations of circulating LDL-C. In randomized trials, inclisiran demonstra...

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Hauptverfasser: Makhmudova, Umidakhon (VerfasserIn) , Schatz, U. (VerfasserIn) , Perakakis, N. (VerfasserIn) , Kassner, U. (VerfasserIn) , Schumann, F. (VerfasserIn) , Axthelm, C. (VerfasserIn) , Stürzebecher, P. (VerfasserIn) , Sinning, D. L. (VerfasserIn) , Doevelaar, A. (VerfasserIn) , Rohn, B. (VerfasserIn) , Westhoff, T. (VerfasserIn) , Vogt, A. (VerfasserIn) , Scholl, M. (VerfasserIn) , Kästner, U. (VerfasserIn) , Geiling, J.-A. (VerfasserIn) , Stach-Jablonski, Ksenija (VerfasserIn) , Mensch, J. (VerfasserIn) , Lorenz, E. (VerfasserIn) , Paitazoglou, C. (VerfasserIn) , Eitel, I. (VerfasserIn) , Baessler, A. (VerfasserIn) , Steinhagen-Thiessen, E. (VerfasserIn) , Koenig, W. (VerfasserIn) , Schulze, P. C. (VerfasserIn) , Landmesser, U. (VerfasserIn) , Laufs, U. (VerfasserIn) , Weingärtner, Oliver (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: November 2023
In: Clinical research in cardiology
Year: 2023, Jahrgang: 112, Heft: 11, Pages: 1639-1649
ISSN:1861-0692
DOI:10.1007/s00392-023-02247-8
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00392-023-02247-8
Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s00392-023-02247-8
Volltext
Verfasserangaben:U. Makhmudova, U. Schatz, N. Perakakis, U. Kassner, F. Schumann, C. Axthelm, P. Stürzebecher, D. L. Sinning, A. Doevelaar, B. Rohn, T. Westhoff, A. Vogt, M. Scholl, U. Kästner, J.-A. Geiling, K. Stach, J. Mensch, E. Lorenz, C. Paitazoglou, I. Eitel, A. Baessler, E. Steinhagen-Thiessen, W. Koenig, P. C. Schulze, U. Landmesser, U. Laufs, Oliver Weingärtner, for the German Inclisiran Network (GIN)

MARC

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