Dedifferentiated and undifferentiated ovarian carcinoma: an aggressive and molecularly distinct ovarian tumor characterized by frequent SWI/SNF complex inactivation
Dedifferentiated and undifferentiated ovarian carcinomas (DDOC/UDOC) are rare neoplasms defined by the presence of an undifferentiated carcinoma. In this study, we detailed the clinical, pathological, immunohistochemical, and molecular features of a series of DDOC/UDOC. We collected a multiinstituti...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
January 2024
|
| In: |
Modern pathology
Year: 2024, Volume: 37, Issue: 1, Pages: 1-12 |
| ISSN: | 1530-0285 |
| DOI: | 10.1016/j.modpat.2023.100374 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.modpat.2023.100374 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S089339522300279X?via%3Dihub 
|
| Author Notes: | Basile Tessier-Cloutier, Felix K.F. Kommoss, David L. Kolin, Kristyna Nemejcova, Dupreez Smith, Jennifer Pors, Colin J.R. Stewart, W. Glenn Mccluggage, William D. Foulkes, Andreas von Deimling, Martin Kobel, Cheng-Han Lee |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1897494564 | ||
| 003 | DE-627 | ||
| 005 | 20241205155944.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240802s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.modpat.2023.100374 |2 doi | |
| 035 | |a (DE-627)1897494564 | ||
| 035 | |a (DE-599)KXP1897494564 | ||
| 035 | |a (OCoLC)1475305282 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Tessier-Cloutier, Basile |e VerfasserIn |0 (DE-588)1337677752 |0 (DE-627)1897493576 |4 aut | |
| 245 | 1 | 0 | |a Dedifferentiated and undifferentiated ovarian carcinoma |b an aggressive and molecularly distinct ovarian tumor characterized by frequent SWI/SNF complex inactivation |c Basile Tessier-Cloutier, Felix K.F. Kommoss, David L. Kolin, Kristyna Nemejcova, Dupreez Smith, Jennifer Pors, Colin J.R. Stewart, W. Glenn Mccluggage, William D. Foulkes, Andreas von Deimling, Martin Kobel, Cheng-Han Lee |
| 264 | 1 | |c January 2024 | |
| 300 | |b Illustrationen | ||
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 02.08.2024 | ||
| 500 | |a Online veröffentlicht: 03. November 2023 | ||
| 520 | |a Dedifferentiated and undifferentiated ovarian carcinomas (DDOC/UDOC) are rare neoplasms defined by the presence of an undifferentiated carcinoma. In this study, we detailed the clinical, pathological, immunohistochemical, and molecular features of a series of DDOC/UDOC. We collected a multiinstitutional cohort of 23 DDOC/UDOC and performed immunohistochemistry for core switch/sucrose nonfermentable (SWI/SNF) complex proteins (ARID1A, ARID1B, SMARCA4, and SMARCB1), mismatch repair (MMR) proteins, and p53. Array-based genome-wide DNA methylation and copy number variation analyses were performed on a subset of cases with comparison made to a previously reported cohort of undifferentiated endometrial carcinoma (UDEC), small cell carcinoma of the ovary, hypercalcemic type (SCCOHT), and tubo-ovarian high-grade serous carcinoma (HGSC). The age of all 23 patients with DDOC/UDOC ranged between 22 and 71 years (with an average age of 50 years), and a majority of them presented with extraovarian disease (16/23). Clinical follow-up was available for 19 patients. Except for 2 patients, the remaining 17 patients died from disease, with rapid disease progression resulting in mortality within a year in stage IIeIV settings (median disease-specific survival of 3 months). Eighteen of 22 cases with interpretable immunohistochemistry results showed loss of expression of core SWI/SNF protein(s) that are expected to result in SWI/ SNF complex inactivation as 10 exhibited coloss of ARID1A and ARID1B, 7 loss of SMARCA4, and 1 loss of SMARCB1. Six of 23 cases were MMR-deficient. Two of 20 cases exhibited mutation-type p53 immunoreactivity. Methylation profiles showed coclustering of DDOC/UDOC with UDEC, which collectively were distinct from SCCOHT and HGSC. However, DDOC/UDOC showed an intermediate degree of copy number variation, which was slightly greater, compared with SCCOHT but much less | ||
| 650 | 4 | |a ARID1B | |
| 650 | 4 | |a ENDOMETRIOID CARCINOMA | |
| 650 | 4 | |a methylation | |
| 650 | 4 | |a PROTEIN EXPRESSION | |
| 650 | 4 | |a SMALL-CELL CARCINOMA | |
| 650 | 4 | |a SMARCA4 | |
| 650 | 4 | |a SMARCB1 | |
| 650 | 4 | |a SWI/SNF | |
| 650 | 4 | |a undifferentiated ovarian carcinoma | |
| 700 | 1 | |a Kommoss, Felix |d 1991- |e VerfasserIn |0 (DE-588)1171010427 |0 (DE-627)1040361315 |0 (DE-576)512915164 |4 aut | |
| 700 | 1 | |a Kolin, David L. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nemejcova, Kristyna |e VerfasserIn |4 aut | |
| 700 | 1 | |a Smith, Dupreez |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pors, Jennifer |e VerfasserIn |4 aut | |
| 700 | 1 | |a Stewart, Colin J. R. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mccluggage, W. Glenn |e VerfasserIn |4 aut | |
| 700 | 1 | |a Foulkes, William D. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Deimling, Andreas von |d 1959- |e VerfasserIn |0 (DE-588)103034115X |0 (DE-627)735093946 |0 (DE-576)378138065 |4 aut | |
| 700 | 1 | |a Kobel, Martin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lee, Cheng-Han |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Modern pathology |d London : Nature Publishing Group, 1988 |g 37(2024), 1 vom: Jan., Artikel-ID 100374, Seite 1-12 |h Online-Ressource |w (DE-627)326643419 |w (DE-600)2041318-X |w (DE-576)283165553 |x 1530-0285 |7 nnas |a Dedifferentiated and undifferentiated ovarian carcinoma an aggressive and molecularly distinct ovarian tumor characterized by frequent SWI/SNF complex inactivation |
| 773 | 1 | 8 | |g volume:37 |g year:2024 |g number:1 |g month:01 |g elocationid:100374 |g pages:1-12 |g extent:12 |a Dedifferentiated and undifferentiated ovarian carcinoma an aggressive and molecularly distinct ovarian tumor characterized by frequent SWI/SNF complex inactivation |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.modpat.2023.100374 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S089339522300279X?via%3Dihub |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20240802 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 103034115X |a Deimling, Andreas von |m 103034115X:Deimling, Andreas von |d 910000 |d 912000 |e 910000PD103034115X |e 912000PD103034115X |k 0/910000/ |k 1/910000/912000/ |p 10 | ||
| 998 | |g 1171010427 |a Kommoss, Felix |m 1171010427:Kommoss, Felix |d 910000 |d 912000 |e 910000PK1171010427 |e 912000PK1171010427 |k 0/910000/ |k 1/910000/912000/ |p 2 | ||
| 999 | |a KXP-PPN1897494564 |e 4562028815 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Basile Tessier-Cloutier, Felix K.F. Kommoss, David L. Kolin, Kristyna Nemejcova, Dupreez Smith, Jennifer Pors, Colin J.R. Stewart, W. Glenn Mccluggage, William D. Foulkes, Andreas von Deimling, Martin Kobel, Cheng-Han Lee"]},"person":[{"role":"aut","family":"Tessier-Cloutier","given":"Basile","display":"Tessier-Cloutier, Basile"},{"role":"aut","family":"Kommoss","given":"Felix","display":"Kommoss, Felix"},{"display":"Kolin, David L.","role":"aut","family":"Kolin","given":"David L."},{"role":"aut","given":"Kristyna","family":"Nemejcova","display":"Nemejcova, Kristyna"},{"display":"Smith, Dupreez","role":"aut","given":"Dupreez","family":"Smith"},{"role":"aut","family":"Pors","given":"Jennifer","display":"Pors, Jennifer"},{"display":"Stewart, Colin J. R.","given":"Colin J. R.","family":"Stewart","role":"aut"},{"role":"aut","family":"Mccluggage","given":"W. Glenn","display":"Mccluggage, W. Glenn"},{"role":"aut","given":"William D.","family":"Foulkes","display":"Foulkes, William D."},{"role":"aut","family":"Deimling","given":"Andreas von","display":"Deimling, Andreas von"},{"display":"Kobel, Martin","given":"Martin","family":"Kobel","role":"aut"},{"display":"Lee, Cheng-Han","given":"Cheng-Han","family":"Lee","role":"aut"}],"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"title":[{"title_sort":"Dedifferentiated and undifferentiated ovarian carcinoma","title":"Dedifferentiated and undifferentiated ovarian carcinoma","subtitle":"an aggressive and molecularly distinct ovarian tumor characterized by frequent SWI/SNF complex inactivation"}],"origin":[{"dateIssuedDisp":"January 2024","dateIssuedKey":"2024"}],"relHost":[{"disp":"Dedifferentiated and undifferentiated ovarian carcinoma an aggressive and molecularly distinct ovarian tumor characterized by frequent SWI/SNF complex inactivationModern pathology","physDesc":[{"extent":"Online-Ressource"}],"id":{"eki":["326643419"],"zdb":["2041318-X"],"issn":["1530-0285"]},"recId":"326643419","note":["Gesehen am 15.01.26","Fortsetzung der Druck-Ausgabe"],"part":{"pages":"1-12","volume":"37","extent":"12","issue":"1","text":"37(2024), 1 vom: Jan., Artikel-ID 100374, Seite 1-12","year":"2024"},"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"origin":[{"publisher":"Elsevier ; Lippincott Williams & Wilkins ; Ovid ; Nature Publishing Group","dateIssuedDisp":"2023-","dateIssuedKey":"2023","publisherPlace":"Amsterdam ; Hagerstown, Md. ; [Erscheinungsort nicht ermittelbar] ; London"}],"title":[{"subtitle":"an official journal of the United States and Canadian Academy of Pathology (USCAP)","title_sort":"Modern pathology","title":"Modern pathology"}],"pubHistory":["1.1988 -"]}],"id":{"doi":["10.1016/j.modpat.2023.100374"],"eki":["1897494564"]},"recId":"1897494564","physDesc":[{"extent":"12 S.","noteIll":"Illustrationen"}],"note":["Gesehen am 02.08.2024","Online veröffentlicht: 03. November 2023"]} | ||
| SRT | |a TESSIERCLODEDIFFEREN2024 | ||