Endothelial cells drive organ fibrosis in mice by inducing expression of the transcription factor SOX9
Fibrosis is a hallmark of chronic disease. Although fibroblasts are involved, it is unclear to what extent endothelial cells also might contribute. We detected increased expression of the transcription factor Sox9 in endothelial cells in several different mouse fibrosis models. These models included...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
February 2024
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| In: |
Science translational medicine
Year: 2024, Jahrgang: 16, Heft: 736, Pages: 1-16 |
| ISSN: | 1946-6242 |
| DOI: | 10.1126/scitranslmed.abq4581 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1126/scitranslmed.abq4581 Verlag, lizenzpflichtig, Volltext: https://www.science.org/doi/10.1126/scitranslmed.abq4581 |
| Verfasserangaben: | Felix A. Trogisch, Aya Abouissa, Merve Keles, Anne Birke, Manuela Fuhrmann, Gesine M. Dittrich, Nina Weinzierl, Elvira Wink, Julio Cordero, Adel Elsherbiny, Abel Martin-Garrido, Steve Grein, Shruthi Hemanna, Ellen Hofmann, Luka Nicin, Sofia-Iris Bibli, Rannar Airik, Andreas Kispert, Ralf Kist, Sun Quanchao, Sina W. Kürschner, Manuel Winkler, Norbert Gretz, Carolin Mogler, Thomas Korff, Philipp-Sebastian Koch, Stefanie Dimmeler, Gergana Dobreva, Joerg Heineke |
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