COVID-19 infection in patients with history of pediatric heart transplant in Germany, Austria, and Switzerland
COVID-19 is a heterogenous infection-asymptomatic to fatal. While the course of pediatric COVID-19 infections is usually mild or even asymptomatic, individuals after adult heart transplantation are at high risk of a severe infection. We conducted a retrospective, multicenter survey of 16 pediatric h...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
March 2024
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| In: |
Clinical transplantation
Year: 2024, Jahrgang: 38, Heft: 3, Pages: 1-7 |
| ISSN: | 1399-0012 |
| DOI: | 10.1111/ctr.15272 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1111/ctr.15272 Verlag, kostenfrei, Volltext: https://www.webofscience.com/api/gateway?GWVersion=2&SrcAuth=DynamicDOIArticle&SrcApp=WOS&KeyAID=10.1111%2Fctr.15272&DestApp=DOI&SrcAppSID=EUW1ED0CE5hHp47VRxNYj6cUZ94Id&SrcJTitle=CLINICAL+TRANSPLANTATION&DestDOIRegistrantName=Wiley+%28Blackwell+Publishing%29 
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| Verfasserangaben: | Sarah Ulrich, Christian Balmer, Kolja Becker, Josefin Bruhs, Friederike Danne, Volker Debus, Leonie Dewein, Stefano Di-Bernardo, Ulrike Doll, Thilo Fleck, Theodor Tirilomis, Martin Glockler, Maria Grafmann, Sabine Greil, Urte Grosser, Patrick Saur, Susanne Skrzypek, Michael Steinmetz, on behalf of the Working group thoracic organ transplantation DGPK |
MARC
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| 520 | |a COVID-19 is a heterogenous infection-asymptomatic to fatal. While the course of pediatric COVID-19 infections is usually mild or even asymptomatic, individuals after adult heart transplantation are at high risk of a severe infection. We conducted a retrospective, multicenter survey of 16 pediatric heart transplant centers in Germany, Austria and Switzerland to evaluate the risk of a severe COVID-19 infection after pediatric heart transplantation between 02/2020 and 06/2021. Twenty-six subjects (11 male) with a median age of 9.77 years at time of transplantation and a median of 4.65 years after transplantation suffered from COVID-19 infection. The median age at time of COVID-10 infection was 17.20 years. Fourteen subjects had an asymptomatic COVID-19 infection. The most frequent symptoms were myalgia/fatigue (n = 6), cough (n = 5), rhinitis (n = 5), and loss of taste (n = 5). Only one subject showed dyspnea. Eleven individuals needed therapy in an outpatient setting, four subjects were hospitalized. One person needed oxygen supply, none of the subjects needed non-invasive or invasive mechanical ventilation. No specific signs for graft dysfunction were found by non-invasive testing. In pediatric heart transplant subjects, COVID-19 infection was mostly asymptomatic or mild. There were no SARS-CoV-2 associated myocardial dysfunction in heart transplant individuals. | ||
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| 650 | 4 | |a pediatric heart transplantation | |
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| 650 | 4 | |a SARS-CoV-2 associated myocardial dysfunction | |
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