Brain energy metabolism: a roadmap for future research
Although we have learned much about how the brain fuels its functions over the last decades, there remains much still to discover in an organ that is so complex. This article lays out major gaps in our knowledge of interrelationships between brain metabolism and brain function, including biochemical...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
May 2024
|
| In: |
Journal of neurochemistry
Year: 2024, Jahrgang: 168, Heft: 5, Pages: 910-954 |
| ISSN: | 1471-4159 |
| DOI: | 10.1111/jnc.16032 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1111/jnc.16032 Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/jnc.16032 
|
| Verfasserangaben: | Caroline D. Rae, Joseph A. Baur, Karin Borges, Gerald Dienel, Carlos Manlio Díaz-García, Starlette R. Douglass, Kelly Drew, João M.N. Duarte, Jordi Duran, Oliver Kann, Tibor Kristian, Dasfne Lee-Liu, Britta E. Lindquist, Ewan C. McNay, Michael B. Robinson, Douglas L. Rothman, Benjamin D. Rowlands, Timothy A. Ryan, Joseph Scafidi, Susanna Scafidi, C. William Shuttleworth, Raymond A. Swanson, Gökhan Uruk, Nina Vardjan, Robert Zorec, Mary C. McKenna |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1897727186 | ||
| 003 | DE-627 | ||
| 005 | 20241205160243.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240805s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1111/jnc.16032 |2 doi | |
| 035 | |a (DE-627)1897727186 | ||
| 035 | |a (DE-599)KXP1897727186 | ||
| 035 | |a (OCoLC)1475305591 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Rae, Caroline |e VerfasserIn |0 (DE-588)1337900729 |0 (DE-627)1897727992 |4 aut | |
| 245 | 1 | 0 | |a Brain energy metabolism |b a roadmap for future research |c Caroline D. Rae, Joseph A. Baur, Karin Borges, Gerald Dienel, Carlos Manlio Díaz-García, Starlette R. Douglass, Kelly Drew, João M.N. Duarte, Jordi Duran, Oliver Kann, Tibor Kristian, Dasfne Lee-Liu, Britta E. Lindquist, Ewan C. McNay, Michael B. Robinson, Douglas L. Rothman, Benjamin D. Rowlands, Timothy A. Ryan, Joseph Scafidi, Susanna Scafidi, C. William Shuttleworth, Raymond A. Swanson, Gökhan Uruk, Nina Vardjan, Robert Zorec, Mary C. McKenna |
| 264 | 1 | |c May 2024 | |
| 300 | |b Illustrationen | ||
| 300 | |a 45 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Zuerst veröffentlicht: 06. Januar 2024 | ||
| 500 | |a Gesehen am 05.08.2024 | ||
| 520 | |a Although we have learned much about how the brain fuels its functions over the last decades, there remains much still to discover in an organ that is so complex. This article lays out major gaps in our knowledge of interrelationships between brain metabolism and brain function, including biochemical, cellular, and subcellular aspects of functional metabolism and its imaging in adult brain, as well as during development, aging, and disease. The focus is on unknowns in metabolism of major brain substrates and associated transporters, the roles of insulin and of lipid droplets, the emerging role of metabolism in microglia, mysteries about the major brain cofactor and signaling molecule NAD+, as well as unsolved problems underlying brain metabolism in pathologies such as traumatic brain injury, epilepsy, and metabolic downregulation during hibernation. It describes our current level of understanding of these facets of brain energy metabolism as well as a roadmap for future research. | ||
| 650 | 4 | |a acetate | |
| 650 | 4 | |a aerobic glycolysis | |
| 650 | 4 | |a GLUT4 | |
| 650 | 4 | |a insulin | |
| 650 | 4 | |a noradrenaline | |
| 700 | 1 | |a Baur, Joseph A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Borges, Karin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dienel, Gerald |e VerfasserIn |4 aut | |
| 700 | 1 | |a Díaz-García, Carlos Manlio |e VerfasserIn |4 aut | |
| 700 | 1 | |a Douglass, Starlette R. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Drew, Kelly |e VerfasserIn |4 aut | |
| 700 | 1 | |a Duarte, João M. N. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Duran, Jordi |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kann, Oliver |d 1971- |e VerfasserIn |0 (DE-588)123125812 |0 (DE-627)70617223X |0 (DE-576)293567255 |4 aut | |
| 700 | 1 | |a Kristian, Tibor |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lee-Liu, Dasfne |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lindquist, Britta E. |e VerfasserIn |4 aut | |
| 700 | 1 | |a McNay, Ewan C. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Robinson, Michael B. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rothman, Douglas L. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rowlands, Benjamin D. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ryan, Timothy A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Scafidi, Joseph |e VerfasserIn |4 aut | |
| 700 | 1 | |a Scafidi, Susanna |e VerfasserIn |4 aut | |
| 700 | 1 | |a Shuttleworth, C. William |e VerfasserIn |4 aut | |
| 700 | 1 | |a Swanson, Raymond A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Uruk, Gökhan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Vardjan, Nina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zorec, Robert |e VerfasserIn |4 aut | |
| 700 | 1 | |a McKenna, Mary C. |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of neurochemistry |d Oxford : Wiley-Blackwell, 1956 |g 168(2024), 5 vom: Mai, Seite 910-954 |h Online-Ressource |w (DE-627)320604063 |w (DE-600)2020528-4 |w (DE-576)091137454 |x 1471-4159 |7 nnas |a Brain energy metabolism a roadmap for future research |
| 773 | 1 | 8 | |g volume:168 |g year:2024 |g number:5 |g month:05 |g pages:910-954 |g extent:45 |a Brain energy metabolism a roadmap for future research |
| 856 | 4 | 0 | |u https://doi.org/10.1111/jnc.16032 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1111/jnc.16032 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20240805 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 123125812 |a Kann, Oliver |m 123125812:Kann, Oliver |d 50000 |d 53200 |e 50000PK123125812 |e 53200PK123125812 |k 0/50000/ |k 1/50000/53200/ |p 10 | ||
| 999 | |a KXP-PPN1897727186 |e 4562761164 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"roleDisplay":"VerfasserIn","display":"Rae, Caroline","role":"aut","family":"Rae","given":"Caroline"},{"given":"Joseph A.","family":"Baur","role":"aut","roleDisplay":"VerfasserIn","display":"Baur, Joseph A."},{"given":"Karin","family":"Borges","role":"aut","display":"Borges, Karin","roleDisplay":"VerfasserIn"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Dienel, Gerald","given":"Gerald","family":"Dienel"},{"family":"Díaz-García","given":"Carlos Manlio","display":"Díaz-García, Carlos Manlio","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Douglass","given":"Starlette R.","display":"Douglass, Starlette R.","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Kelly","family":"Drew","role":"aut","display":"Drew, Kelly","roleDisplay":"VerfasserIn"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Duarte, João M. N.","given":"João M. N.","family":"Duarte"},{"family":"Duran","given":"Jordi","display":"Duran, Jordi","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Kann, Oliver","given":"Oliver","family":"Kann"},{"role":"aut","display":"Kristian, Tibor","roleDisplay":"VerfasserIn","given":"Tibor","family":"Kristian"},{"family":"Lee-Liu","given":"Dasfne","display":"Lee-Liu, Dasfne","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Britta E.","family":"Lindquist","role":"aut","roleDisplay":"VerfasserIn","display":"Lindquist, Britta E."},{"given":"Ewan C.","family":"McNay","role":"aut","roleDisplay":"VerfasserIn","display":"McNay, Ewan C."},{"family":"Robinson","given":"Michael B.","display":"Robinson, Michael B.","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Rothman","given":"Douglas L.","roleDisplay":"VerfasserIn","display":"Rothman, Douglas L.","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Rowlands, Benjamin D.","role":"aut","family":"Rowlands","given":"Benjamin D."},{"display":"Ryan, Timothy A.","roleDisplay":"VerfasserIn","role":"aut","family":"Ryan","given":"Timothy A."},{"given":"Joseph","family":"Scafidi","role":"aut","roleDisplay":"VerfasserIn","display":"Scafidi, Joseph"},{"display":"Scafidi, Susanna","roleDisplay":"VerfasserIn","role":"aut","family":"Scafidi","given":"Susanna"},{"given":"C. William","family":"Shuttleworth","role":"aut","roleDisplay":"VerfasserIn","display":"Shuttleworth, C. William"},{"given":"Raymond A.","family":"Swanson","role":"aut","roleDisplay":"VerfasserIn","display":"Swanson, Raymond A."},{"family":"Uruk","given":"Gökhan","roleDisplay":"VerfasserIn","display":"Uruk, Gökhan","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Vardjan, Nina","role":"aut","family":"Vardjan","given":"Nina"},{"family":"Zorec","given":"Robert","roleDisplay":"VerfasserIn","display":"Zorec, Robert","role":"aut"},{"roleDisplay":"VerfasserIn","display":"McKenna, Mary C.","role":"aut","family":"McKenna","given":"Mary C."}],"title":[{"title_sort":"Brain energy metabolism","title":"Brain energy metabolism","subtitle":"a roadmap for future research"}],"language":["eng"],"recId":"1897727186","note":["Zuerst veröffentlicht: 06. Januar 2024","Gesehen am 05.08.2024"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"name":{"displayForm":["Caroline D. Rae, Joseph A. Baur, Karin Borges, Gerald Dienel, Carlos Manlio Díaz-García, Starlette R. Douglass, Kelly Drew, João M.N. Duarte, Jordi Duran, Oliver Kann, Tibor Kristian, Dasfne Lee-Liu, Britta E. Lindquist, Ewan C. McNay, Michael B. Robinson, Douglas L. Rothman, Benjamin D. Rowlands, Timothy A. Ryan, Joseph Scafidi, Susanna Scafidi, C. William Shuttleworth, Raymond A. Swanson, Gökhan Uruk, Nina Vardjan, Robert Zorec, Mary C. McKenna"]},"id":{"doi":["10.1111/jnc.16032"],"eki":["1897727186"]},"origin":[{"dateIssuedKey":"2024","dateIssuedDisp":"May 2024"}],"relHost":[{"id":{"doi":["10.1111/(ISSN)1471-4159"],"eki":["320604063"],"zdb":["2020528-4"],"issn":["1471-4159"]},"origin":[{"publisher":"Wiley-Blackwell ; HighWire Press ; Blackwell","dateIssuedKey":"1956","dateIssuedDisp":"1956-","publisherPlace":"Oxford ; Stanford, Calif. ; Oxford [u.a.]"}],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Journal of neurochemistry","title":"Journal of neurochemistry","subtitle":"official journal of the International Society for Neurochemistry ; JNC"}],"titleAlt":[{"title":"JNC"}],"part":{"extent":"45","text":"168(2024), 5 vom: Mai, Seite 910-954","volume":"168","pages":"910-954","issue":"5","year":"2024"},"pubHistory":["1.1956/57 -"],"recId":"320604063","corporate":[{"display":"International Society for Neurochemistry","roleDisplay":"Herausgebendes Organ","role":"isb"}],"language":["eng"],"disp":"Brain energy metabolism a roadmap for future researchJournal of neurochemistry","type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Fortsetzung der Druck-Ausgabe","Gesehen am 08.04.22"]}],"physDesc":[{"noteIll":"Illustrationen","extent":"45 S."}]} | ||
| SRT | |a RAECAROLINBRAINENERG2024 | ||