Statement of the Uterus Commission of the Gynecological Oncology Working Group (AGO) on the use of primary chemoimmunotherapy to treat patients with locally advanced or recurrent endometrial cancer = Stellungnahme der Kommission Uterus der Arbeitsgemeinschaft Gynäkologische Onkologie (AGO) zur primären Chemo- Immuntherapie bei Patientinnen mit lokal fortgeschrittenem oder rezidiviertem Endometriumkarzinom
The publication of two large randomized studies - the ENGOT-EN-6-NSGO/GOG-3031/RUBY trial and the NRG-GY018 trial - which investigated combining chemotherapy with immunotherapy to treat patients with primary advanced or recurrent endometrial cancer (EC) has transformed the clinical study landscape i...
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| Main Authors: | , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
12. September 2023
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| In: |
Geburtshilfe und Frauenheilkunde
Year: 2023, Volume: 83, Issue: 9, Pages: 1095-1101 |
| ISSN: | 1438-8804 |
| DOI: | 10.1055/a-2145-1545 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1055/a-2145-1545 Verlag, kostenfrei, Volltext: http://www.thieme-connect.de/DOI/DOI?10.1055/a-2145-1545 
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| Author Notes: | authors: Clemens Tempfer, Sara Brucker, Ingolf Juhasz-Boess, Peter Mallmann, Eric Steiner, Dominik Denschlag, Peter Hillemanns, Markus Wallwiener, Matthias W. Beckmann, for the Uterus Commission of the Ago |
MARC
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| 245 | 1 | 0 | |a Statement of the Uterus Commission of the Gynecological Oncology Working Group (AGO) on the use of primary chemoimmunotherapy to treat patients with locally advanced or recurrent endometrial cancer |b = Stellungnahme der Kommission Uterus der Arbeitsgemeinschaft Gynäkologische Onkologie (AGO) zur primären Chemo- Immuntherapie bei Patientinnen mit lokal fortgeschrittenem oder rezidiviertem Endometriumkarzinom |c authors: Clemens Tempfer, Sara Brucker, Ingolf Juhasz-Boess, Peter Mallmann, Eric Steiner, Dominik Denschlag, Peter Hillemanns, Markus Wallwiener, Matthias W. Beckmann, for the Uterus Commission of the Ago |
| 246 | 3 | 1 | |a Stellungnahme der Kommission Uterus der Arbeitsgemeinschaft Gynäkologische Onkologie (AGO) zur primären Chemo- Immuntherapie bei Patientinnen mit lokal fortgeschrittenem oder rezidiviertem Endometriumkarzinom |
| 264 | 1 | |c 12. September 2023 | |
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| 520 | |a The publication of two large randomized studies - the ENGOT-EN-6-NSGO/GOG-3031/RUBY trial and the NRG-GY018 trial - which investigated combining chemotherapy with immunotherapy to treat patients with primary advanced or recurrent endometrial cancer (EC) has transformed the clinical study landscape in terms of first-line therapy for affected patients and has set a new standard of therapy. In the ENGOT-EN-6-NSGO/GOG-3031/RUBY trial, the addition of dostarlimab to standard chemotherapy with carboplatin and paclitaxel resulted in. In the NRG-GY018 trial, the addition of pembrolizumab to standard chemotherapy with carboplatin and paclitaxel resulted in</p> <p>As expected, the effect in both trials was much more pronounced in the group of patients with dMMR/MSI-high tumors. According to the assessment of the Uterus Organ Commission of the AGO, all patients with dMMR/MSI-high tumors should receive chemoimmunotherapy and all patients with pMMR/MSI-low tumors who meet the inclusion criteria of the two trials discussed here may have chemoimmunotherapy. | ||
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| 773 | 1 | 8 | |g volume:83 |g year:2023 |g number:9 |g pages:1095-1101 |g extent:7 |a Statement of the Uterus Commission of the Gynecological Oncology Working Group (AGO) on the use of primary chemoimmunotherapy to treat patients with locally advanced or recurrent endometrial cancer = Stellungnahme der Kommission Uterus der Arbeitsgemeinschaft Gynäkologische Onkologie (AGO) zur primären Chemo- Immuntherapie bei Patientinnen mit lokal fortgeschrittenem oder rezidiviertem Endometriumkarzinom |
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