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The German CaRe high registry for familial hypercholesterolemia: Sex differences, treatment strategies, and target value attainment

Background and aims - Familial hypercholesterolemia (FH) is among the most common genetic disorders in primary care. However, only 15% or less of patients are diagnosed, and few achieve the goals for low-density lipoprotein cholesterol (LDL-C). In this analysis of the German Cascade Screening and Re...

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Hauptverfasser: März, Winfried (VerfasserIn) , Schmidt, Nina (VerfasserIn) , an Haack, Ira (VerfasserIn) , Dressel, Alexander (VerfasserIn) , Grammer, Tanja B. (VerfasserIn) , Kleber, Marcus E. (VerfasserIn) , Baessler, Andrea (VerfasserIn) , Beil, F. Ulrich (VerfasserIn) , Gouni-Berthold, Ioanna (VerfasserIn) , Julius, Ulrich (VerfasserIn) , Kassner, Ursula (VerfasserIn) , Katzmann, Julius L. (VerfasserIn) , Klose, Gerald (VerfasserIn) , König, Christel (VerfasserIn) , Koenig, Wolfgang (VerfasserIn) , Koschker, Ann-Cathrin (VerfasserIn) , Laufs, Ulrich (VerfasserIn) , Merkel, Martin (VerfasserIn) , Otte, Britta (VerfasserIn) , Parhofer, Klaus G. (VerfasserIn) , Hengstenberg, Wibke (VerfasserIn) , Schunkert, Heribert (VerfasserIn) , Stach-Jablonski, Ksenija (VerfasserIn) , Steinhagen-Thiessen, Elisabeth (VerfasserIn) , Olivier, Christoph (VerfasserIn) , Hahmann, Harry (VerfasserIn) , Krzossok, Stefan (VerfasserIn) , Vogt, Anja (VerfasserIn) , Müller-Wieland, Dirk (VerfasserIn) , Schatz, Ulrike (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: September 2023
In: Atherosclerosis plus
Year: 2023, Jahrgang: 53, Pages: 6-15
ISSN:2667-0895
DOI:10.1016/j.athplu.2023.06.001
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.athplu.2023.06.001
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S2667089523000093
Volltext
Verfasserangaben:Winfried März, Nina Schmidt, Ira an Haack, Alexander Dressel, Tanja B. Grammer, Marcus E. Kleber, Andrea Baessler, F. Ulrich Beil, Ioanna Gouni-Berthold, Ulrich Julius, Ursula Kassner, Julius L. Katzmann, Gerald Klose, Christel König, Wolfgang Koenig, Ann-Cathrin Koschker, Ulrich Laufs, Martin Merkel, Britta Otte, Klaus G. Parhofer, Wibke Hengstenberg, Heribert Schunkert, Ksenija Stach-Jablonski, Elisabeth Steinhagen-Thiessen, Christoph B. Olivier, Harry Hahmann, Stefan Krzossok, Anja Vogt, Dirk Müller-Wieland, Ulrike Schatz
Beschreibung
Zusammenfassung:Background and aims - Familial hypercholesterolemia (FH) is among the most common genetic disorders in primary care. However, only 15% or less of patients are diagnosed, and few achieve the goals for low-density lipoprotein cholesterol (LDL-C). In this analysis of the German Cascade Screening and Registry for High Cholesterol (CaRe High), we examined the status of lipid management, treatment strategies, and LDL-C goal attainment according to the ESC/EAS dyslipidemia guidelines. - Methods - We evaluated consolidated datasets from 1501 FH patients diagnosed clinically and seen either by lipid specialists or general practitioners and internists. We conducted a questionnaire survey of both the recruiting physicians and patients. - Results - Among the 1501 patients, 86% regularly received lipid-lowering drugs. LDL-C goals were achieved by 26% and 10% of patients with atherosclerotic cardiovascular disease (ASCVD) according to the 2016 and 2019 ESC/EAS dyslipidemia guidelines, respectively. High intensity lipid-lowering was administered more often in men than in women, in patients with ASCVD, at higher LDL-C and in patients with a genetic diagnosis of FH. - Conclusions - FH is under-treated in Germany compared to guideline recommendations. Male gender, genetic proof of FH, treatment by a specialist, and presence of ASCVD appear to be associated with increased treatment intensity. Achieving the LDL-C goals of the 2019 ESC/EAS dyslipidemia guidelines remains challenging if pre-treatment LDL-C is very high.
Beschreibung:Online verfügbar: 12. Juni 2023, Artikelversion: 21. Juni 2023
Gesehen am 08.08.2024
Beschreibung:Online Resource
ISSN:2667-0895
DOI:10.1016/j.athplu.2023.06.001

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