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Smoking influence in Takotsubo syndrome: insights from an international cohort

Aims: To assess the influence of tobacco on acute and long-term outcomes in Takotsubo syndrome (TTS). Methods: Patients with TTS from the international multicenter German Italian Spanish Takotsubo registry (GEIST) were analyzed. Comparisons between groups were performed within the overall cohort, an...

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Hauptverfasser: Núñez-Gil, Iván J. (VerfasserIn) , Santoro, Francesco (VerfasserIn) , Vazirani, Ravi (VerfasserIn) , Novo, Giuseppina (VerfasserIn) , Blanco-Ponce, Emilia (VerfasserIn) , Arcari, Luca (VerfasserIn) , Uribarri, Aitor (VerfasserIn) , Cacciotti, Luca (VerfasserIn) , Guerra, Federico (VerfasserIn) , Salamanca, Jorge (VerfasserIn) , Musumeci, Beatrice (VerfasserIn) , Vedia, Oscar (VerfasserIn) , Mariano, Enrica (VerfasserIn) , Fernández-Cordón, Clara (VerfasserIn) , Caldarola, Pasquale (VerfasserIn) , Montisci, Roberta (VerfasserIn) , Brunetti, Natale Daniele (VerfasserIn) , El-Battrawy, Ibrahim (VerfasserIn) , Abumayyaleh, Mohammad S. A. (VerfasserIn) , Akın, Ibrahim (VerfasserIn) , Eitel, Ingo (VerfasserIn) , Stiermaier, Thomas (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 20 November 2023
In: Frontiers in Cardiovascular Medicine
Year: 2023, Jahrgang: 10, Pages: 1-9
ISSN:2297-055X
DOI:10.3389/fcvm.2023.1282018
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.3389/fcvm.2023.1282018
Verlag, kostenfrei, Volltext: https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2023.1282018/full
Volltext
Verfasserangaben:Iván J. Núñez-Gil, Francesco Santoro, Ravi Vazirani, Giuseppina Novo, Emilia Blanco-Ponce, Luca Arcari, Aitor Uribarri, Luca Cacciotti, Federico Guerra, Jorge Salamanca, Beatrice Musumeci, Oscar Vedia, Enrica Mariano, Clara Fernández-Cordón, Pasquale Caldarola, Roberta Montisci, Natale Daniele Brunetti, Ibrahim El-Battrawy, Mohammad Abumayyaleh, Ibrahim Akin, Ingo Eitel and Thomas Stiermaier
Beschreibung
Zusammenfassung:Aims: To assess the influence of tobacco on acute and long-term outcomes in Takotsubo syndrome (TTS). Methods: Patients with TTS from the international multicenter German Italian Spanish Takotsubo registry (GEIST) were analyzed. Comparisons between groups were performed within the overall cohort, and an adjusted analysis with 1:1 propensity score matching was conducted. Results: Out of 3,152 patients with TTS, 534 (17%) were current smokers. Smoker TTS patients were younger (63 ± 11 vs. 72 ± 11 years, p 0.001), less frequently women (78% vs. 90%, p 0.001), and had a lower prevalence of hypertension (59% vs. 69%, p 0.01) and diabetes mellitus (16% vs. 20%, p = 0.04), but had a higher prevalence of pulmonary (21% vs. 15%, p 0.01) and/or psychiatric diseases (17% vs. 12%, p 0.01). On multivariable analysis, age less than 65 years [OR 3.85, 95% CI (2.86-5)], male gender [OR 2.52, 95% CI (1.75-3.64)], history of pulmonary disease [OR 2.56, 95% CI (1.81-3.61)], coronary artery disease [OR 2.35, 95% CI (1.60-3.46)], and non-apical ballooning form [OR 1.47, 95% CI (1.02-2.13)] were associated with smoking status. Propensity score matching (PSM) 1:1 yielded 329 patients from each group. Smokers had a similar rate of in-hospital complications but longer in-hospital stays (10 vs. 9 days, p = 0.01). During long-term follow-up, there were no differences in mortality rates between smokers and non-smokers (5.6% vs. 6.9% yearly in the overall, p = 0.02, and 6.6%, vs. 7.2% yearly in the matched cohort, p = 0.97). Conclusions: Our findings suggest that smoking may influence the clinical presentation and course of TTS with longer in-hospital stays, but does not independently impact mortality.
Beschreibung:Gesehen am 13.08.2024
Beschreibung:Online Resource
ISSN:2297-055X
DOI:10.3389/fcvm.2023.1282018

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