Differential genome analysis applied to the species-specific features of Helicobacter pylori
We introduce a simple and rapid strategy to identify genes that are responsible for species-specific phenotypes. The genome of a species that has a specific phenotype is compared with at least one, closely related, species that lacks this phenotype. Homologous genes that are shared among the species...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
10 April 1998
|
| In: |
FEBS letters
Year: 1998, Volume: 426, Issue: 1, Pages: 1-5 |
| ISSN: | 1873-3468 |
| DOI: | 10.1016/S0014-5793(98)00276-2 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0014-5793(98)00276-2 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0014579398002762 
|
| Author Notes: | Martijn Huynen, Thomas Dandekar, Peer Bork |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 189867907X | ||
| 003 | DE-627 | ||
| 005 | 20241205162741.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240814s1998 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/S0014-5793(98)00276-2 |2 doi | |
| 035 | |a (DE-627)189867907X | ||
| 035 | |a (DE-599)KXP189867907X | ||
| 035 | |a (OCoLC)1475307821 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Huynen, Martijn |e VerfasserIn |0 (DE-588)1338991574 |0 (DE-627)1898679401 |4 aut | |
| 245 | 1 | 0 | |a Differential genome analysis applied to the species-specific features of Helicobacter pylori |c Martijn Huynen, Thomas Dandekar, Peer Bork |
| 264 | 1 | |c 10 April 1998 | |
| 300 | |a 5 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 14.08.2024 | ||
| 520 | |a We introduce a simple and rapid strategy to identify genes that are responsible for species-specific phenotypes. The genome of a species that has a specific phenotype is compared with at least one, closely related, species that lacks this phenotype. Homologous genes that are shared among the species compared are identified and discarded from the list of candidates for species-specific genes. The process is automated and rapidly yields a small subset of the genome that likely contains genes responsible for the species-specific features. Functions are assigned to the genes, and dubious annotations are filtered out. Information is extracted not only from the presence of genes, but also from their absence with respect to known phenotypes. We have applied the technique to identify a set of species-specific genes in Helicobacter pylori by comparing it with its closest relatives for which complete genome sequences are available, Haemophilus influenzae and Escherichia coli. Of the genes of this set for which functional features can be obtained, a large fraction (63%, 123 proteins) is (potentially) involved in H. pylori's interaction with its host. We hypothesize that a family of outer membrane proteins is critical for the ability of H. pylori to colonize host cells in highly acidic environments. | ||
| 650 | 4 | |a Comparative genome analysis | |
| 650 | 4 | |a Outer membrane protein | |
| 650 | 4 | |a Sequence analysis | |
| 650 | 4 | |a Species-specific phenotype | |
| 700 | 1 | |a Dandekar, Thomas |d 1960- |e VerfasserIn |0 (DE-588)120961059 |0 (DE-627)080996604 |0 (DE-576)166308323 |4 aut | |
| 700 | 1 | |a Bork, Peer |d 1963- |e VerfasserIn |0 (DE-588)122539117 |0 (DE-627)705944476 |0 (DE-576)293313946 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |a Vereinigung der Europäischen Biochemischen Gesellschaften |t FEBS letters |d Chichester : Wiley, 1968 |g 426(1998), 1, Seite 1-5 |h Online-Ressource |w (DE-627)253779669 |w (DE-600)1460391-3 |w (DE-576)07279383X |x 1873-3468 |7 nnas |
| 773 | 1 | 8 | |g volume:426 |g year:1998 |g number:1 |g pages:1-5 |g extent:5 |a Differential genome analysis applied to the species-specific features of Helicobacter pylori |
| 856 | 4 | 0 | |u https://doi.org/10.1016/S0014-5793(98)00276-2 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0014579398002762 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20240814 | ||
| 993 | |a Article | ||
| 994 | |a 1998 | ||
| 998 | |g 122539117 |a Bork, Peer |m 122539117:Bork, Peer |p 3 |y j | ||
| 998 | |g 120961059 |a Dandekar, Thomas |m 120961059:Dandekar, Thomas |p 2 | ||
| 999 | |a KXP-PPN189867907X |e 4566131092 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"eki":["189867907X"],"doi":["10.1016/S0014-5793(98)00276-2"]},"name":{"displayForm":["Martijn Huynen, Thomas Dandekar, Peer Bork"]},"origin":[{"dateIssuedKey":"1998","dateIssuedDisp":"10 April 1998"}],"physDesc":[{"extent":"5 S."}],"relHost":[{"language":["eng"],"disp":"Vereinigung der Europäischen Biochemischen GesellschaftenFEBS letters","origin":[{"dateIssuedDisp":"1968-","publisher":"Wiley ; North-Holland Publ. Co. ; Elsevier","publisherPlace":"Chichester ; Amsterdam ; Amsterdam [u.a.]","dateIssuedKey":"1968"}],"physDesc":[{"extent":"Online-Ressource"}],"name":{"displayForm":["Federation of European Biochemical Societies. Ed. M. Avron [u.a.]"]},"title":[{"subtitle":"for the rapid publication of short reports in biochemistry, biophysics, and molecular biology","title_sort":"FEBS letters","title":"FEBS letters"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"pubHistory":["1.1968 -"],"part":{"volume":"426","issue":"1","text":"426(1998), 1, Seite 1-5","pages":"1-5","extent":"5","year":"1998"},"recId":"253779669","note":["Gesehen am 18.12.2019","Fortsetzung der Druck-Ausgabe"],"corporate":[{"role":"aut","roleDisplay":"VerfasserIn","display":"Vereinigung der Europäischen Biochemischen Gesellschaften"}],"id":{"doi":["10.1002/(ISSN)1873-3468"],"issn":["1873-3468"],"eki":["253779669"],"zdb":["1460391-3"]}}],"person":[{"given":"Martijn","role":"aut","roleDisplay":"VerfasserIn","display":"Huynen, Martijn","family":"Huynen"},{"given":"Thomas","role":"aut","roleDisplay":"VerfasserIn","display":"Dandekar, Thomas","family":"Dandekar"},{"display":"Bork, Peer","given":"Peer","roleDisplay":"VerfasserIn","role":"aut","family":"Bork"}],"language":["eng"],"title":[{"title_sort":"Differential genome analysis applied to the species-specific features of Helicobacter pylori","title":"Differential genome analysis applied to the species-specific features of Helicobacter pylori"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 14.08.2024"],"recId":"189867907X"} | ||
| SRT | |a HUYNENMARTDIFFERENTI1019 | ||