Two-photon direct laser writing of pNIPAM actuators in microchannels for dynamic microfluidics
Microfluidic tools enable to investigate and manipulate various chemical and biological processes at small scales. As a result, it finds widespread applications in lab-on-chip devices, drug delivery systems, or miniaturized cell cultures. However, microfluidic devices are still limited in their flex...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
July 2024
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| In: |
Advanced intelligent systems
Year: 2024, Jahrgang: 6, Heft: 7, Pages: 1-11 |
| ISSN: | 2640-4567 |
| DOI: | 10.1002/aisy.202300829 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/aisy.202300829 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/aisy.202300829 
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| Verfasserangaben: | Chantal Barwig, Annabelle Sonn, Tobias Spratte, Ankit Mishra, Eva Blasco, Christine Selhuber-Unkel, and Sadaf Pashapour |
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| 245 | 1 | 0 | |a Two-photon direct laser writing of pNIPAM actuators in microchannels for dynamic microfluidics |c Chantal Barwig, Annabelle Sonn, Tobias Spratte, Ankit Mishra, Eva Blasco, Christine Selhuber-Unkel, and Sadaf Pashapour |
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| 520 | |a Microfluidic tools enable to investigate and manipulate various chemical and biological processes at small scales. As a result, it finds widespread applications in lab-on-chip devices, drug delivery systems, or miniaturized cell cultures. However, microfluidic devices are still limited in their flexibility and are often designed to fulfill a single functionality. Moreover, technologies to introduce dynamic functionalities with high precision and at high resolution after the development of a continuous phase microfluidic chip remain scarce. Herein, two-photon polymerization direct laser writing is introduced as a suitable approach to equip continuous phase microfluidic chips with structurally defined thermoresponsive poly(N-isopropyl-acrylamide) (pNIPAM) microactuators. Harnessing the lower critical phase transition temperature of pNIPAM, and upon controlling specific design parameters, the efficient catch and release of polystyrene beads of different sizes using a pNIPAM micropillar brush array is demonstrated. Moreover, a biocompatible pNIPAM microgripper array is designed to subsequently capture and release differently sized (single) cell populations. Overall, the method offers great flexibility and a high degree of freedom toward the fabrication of dynamic microfluidic devices with great adaptability to experimental conditions in real time. | ||
| 650 | 4 | |a direct laser writing | |
| 650 | 4 | |a dynamic microfluidics | |
| 650 | 4 | |a soft microactuators | |
| 650 | 4 | |a thermoresponsive hydrogels | |
| 650 | 4 | |a two-photon polymerization | |
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| 700 | 1 | |a Mishra, Ankit |d 1994- |e VerfasserIn |0 (DE-588)1280333820 |0 (DE-627)1833427386 |4 aut | |
| 700 | 1 | |a Blasco, Eva |e VerfasserIn |0 (DE-588)1226861067 |0 (DE-627)1747963801 |4 aut | |
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| 700 | 1 | |a Pashapour, Sadaf |d 1994- |e VerfasserIn |0 (DE-588)1211116654 |0 (DE-627)1698964277 |4 aut | |
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| 773 | 1 | 8 | |g volume:6 |g year:2024 |g number:7 |g month:07 |g elocationid:2300829 |g pages:1-11 |g extent:11 |a Two-photon direct laser writing of pNIPAM actuators in microchannels for dynamic microfluidics |
| 787 | 0 | 8 | |i Forschungsdaten |a Barwig, Chantal, 1995 - |t Two-photon direct laser writing of pNIPAM actuators in microchannels for dynamic microfluidics [data] |d Heidelberg : Universität, 2025 |h 1 Online-Ressource (4 Files) |w (DE-627)1940460433 |
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