Characterization of hormone receptor and HER2 status in breast cancer using mass spectrometry imaging
Immunohistochemical evaluation of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor-2 status stratify the different subtypes of breast cancer and define the treatment course. Triple-negative breast cancer (TNBC), which does not register receptor overexpression, is...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2 February 2023
|
| In: |
International journal of molecular sciences
Year: 2023, Jahrgang: 24, Heft: 3, Pages: 1-16 |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms24032860 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/ijms24032860 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/1422-0067/24/3/2860 
|
| Verfasserangaben: | Juliana Pereira Lopes Gonçalves, Christine Bollwein, Aurelia Noske, Anne Jacob, Paul Jank, Sibylle Loibl, Valentina Nekljudova, Peter A. Fasching, Thomas Karn, Frederik Marmé, Volkmar Müller, Christian Schem, Bruno Valentin Sinn, Elmar Stickeler, Marion van Mackelenbergh, Wolfgang D. Schmitt, Carsten Denkert, Wilko Weichert and Kristina Schwamborn |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1899096043 | ||
| 003 | DE-627 | ||
| 005 | 20241205163619.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240819s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/ijms24032860 |2 doi | |
| 035 | |a (DE-627)1899096043 | ||
| 035 | |a (DE-599)KXP1899096043 | ||
| 035 | |a (OCoLC)1475308141 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Gonçalves, Juliana P. L. |e VerfasserIn |0 (DE-588)1274780160 |0 (DE-627)1824543395 |4 aut | |
| 245 | 1 | 0 | |a Characterization of hormone receptor and HER2 status in breast cancer using mass spectrometry imaging |c Juliana Pereira Lopes Gonçalves, Christine Bollwein, Aurelia Noske, Anne Jacob, Paul Jank, Sibylle Loibl, Valentina Nekljudova, Peter A. Fasching, Thomas Karn, Frederik Marmé, Volkmar Müller, Christian Schem, Bruno Valentin Sinn, Elmar Stickeler, Marion van Mackelenbergh, Wolfgang D. Schmitt, Carsten Denkert, Wilko Weichert and Kristina Schwamborn |
| 264 | 1 | |c 2 February 2023 | |
| 300 | |b Illustrationen | ||
| 300 | |a 16 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 19.08.2024 | ||
| 520 | |a Immunohistochemical evaluation of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor-2 status stratify the different subtypes of breast cancer and define the treatment course. Triple-negative breast cancer (TNBC), which does not register receptor overexpression, is often associated with worse patient prognosis. Mass spectrometry imaging transcribes the molecular content of tissue specimens without requiring additional tags or preliminary analysis of the samples, being therefore an excellent methodology for an unbiased determination of tissue constituents, in particular tumor markers. In this study, the proteomic content of 1191 human breast cancer samples was characterized by mass spectrometry imaging and the epithelial regions were employed to train and test machine-learning models to characterize the individual receptor status and to classify TNBC. The classification models presented yielded high accuracies for estrogen and progesterone receptors and over 95% accuracy for classification of TNBC. Analysis of the molecular features revealed that vimentin overexpression is associated with TNBC, supported by immunohistochemistry validation, revealing a new potential target for diagnosis and treatment. | ||
| 650 | 4 | |a breast cancer | |
| 650 | 4 | |a histopathology | |
| 650 | 4 | |a mass spectrometry imaging | |
| 650 | 4 | |a proteomics | |
| 650 | 4 | |a tissue typing | |
| 700 | 1 | |a Bollwein, Christine |e VerfasserIn |4 aut | |
| 700 | 1 | |a Noske, Aurelia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jacob, Anne |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jank, Paul |e VerfasserIn |4 aut | |
| 700 | 1 | |a Loibl, Sibylle |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nekljudova, Valentina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fasching, Peter A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Karn, Thomas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Marmé, Frederik |d 1974- |e VerfasserIn |0 (DE-588)132561972 |0 (DE-627)52394893X |0 (DE-576)299226549 |4 aut | |
| 700 | 1 | |a Müller, Volkmar |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schem, Christian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sinn, Bruno Valentin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Stickeler, Elmar |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mackelenbergh, Marion Tina van |d 1981- |e VerfasserIn |0 (DE-588)133221520 |0 (DE-627)691253633 |0 (DE-576)299705056 |4 aut | |
| 700 | 1 | |a Schmitt, Wolfgang Daniel |d 1975- |e VerfasserIn |0 (DE-588)129977527 |0 (DE-627)485303302 |0 (DE-576)297931547 |4 aut | |
| 700 | 1 | |a Denkert, Carsten |d 1969- |e VerfasserIn |0 (DE-588)118129929 |0 (DE-627)079261124 |0 (DE-576)291730604 |4 aut | |
| 700 | 1 | |a Weichert, Wilko |d 1970-2023 |e VerfasserIn |0 (DE-588)123509106 |0 (DE-627)56134650X |0 (DE-576)293740461 |4 aut | |
| 700 | 1 | |a Schwamborn, Kristina |d 1976- |e VerfasserIn |0 (DE-588)13043745X |0 (DE-627)501474439 |0 (DE-576)29819547X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of molecular sciences |d Basel : Molecular Diversity Preservation International, 2000 |g 24(2023), 3, Artikel-ID 2860, Seite 1-16 |h Online-Ressource |w (DE-627)316340715 |w (DE-600)2019364-6 |w (DE-576)281194653 |x 1422-0067 |7 nnas |a Characterization of hormone receptor and HER2 status in breast cancer using mass spectrometry imaging |
| 773 | 1 | 8 | |g volume:24 |g year:2023 |g number:3 |g elocationid:2860 |g pages:1-16 |g extent:16 |a Characterization of hormone receptor and HER2 status in breast cancer using mass spectrometry imaging |
| 856 | 4 | 0 | |u https://doi.org/10.3390/ijms24032860 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.mdpi.com/1422-0067/24/3/2860 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20240819 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 132561972 |a Marmé, Frederik |m 132561972:Marmé, Frederik |d 60000 |d 61300 |d 50000 |e 60000PM132561972 |e 61300PM132561972 |e 50000PM132561972 |k 0/60000/ |k 1/60000/61300/ |k 0/50000/ |p 10 | ||
| 999 | |a KXP-PPN1899096043 |e 4568027861 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title":"Characterization of hormone receptor and HER2 status in breast cancer using mass spectrometry imaging","title_sort":"Characterization of hormone receptor and HER2 status in breast cancer using mass spectrometry imaging"}],"origin":[{"dateIssuedDisp":"2 February 2023","dateIssuedKey":"2023"}],"note":["Gesehen am 19.08.2024"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"physDesc":[{"extent":"16 S.","noteIll":"Illustrationen"}],"name":{"displayForm":["Juliana Pereira Lopes Gonçalves, Christine Bollwein, Aurelia Noske, Anne Jacob, Paul Jank, Sibylle Loibl, Valentina Nekljudova, Peter A. Fasching, Thomas Karn, Frederik Marmé, Volkmar Müller, Christian Schem, Bruno Valentin Sinn, Elmar Stickeler, Marion van Mackelenbergh, Wolfgang D. Schmitt, Carsten Denkert, Wilko Weichert and Kristina Schwamborn"]},"relHost":[{"language":["eng"],"titleAlt":[{"title":"IJMS"}],"part":{"volume":"24","extent":"16","issue":"3","text":"24(2023), 3, Artikel-ID 2860, Seite 1-16","pages":"1-16","year":"2023"},"title":[{"title":"International journal of molecular sciences","title_sort":"International journal of molecular sciences"}],"origin":[{"dateIssuedDisp":"2000-","publisher":"Molecular Diversity Preservation International","dateIssuedKey":"2000","publisherPlace":"Basel"}],"note":["Gesehen am 17.09.20"],"pubHistory":["1.2000 -"],"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Characterization of hormone receptor and HER2 status in breast cancer using mass spectrometry imagingInternational journal of molecular sciences","physDesc":[{"extent":"Online-Ressource"}],"recId":"316340715","id":{"zdb":["2019364-6"],"issn":["1422-0067","1661-6596"],"eki":["316340715"]}}],"recId":"1899096043","id":{"eki":["1899096043"],"doi":["10.3390/ijms24032860"]},"person":[{"role":"aut","given":"Juliana P. L.","display":"Gonçalves, Juliana P. L.","family":"Gonçalves"},{"family":"Bollwein","display":"Bollwein, Christine","role":"aut","given":"Christine"},{"role":"aut","given":"Aurelia","display":"Noske, Aurelia","family":"Noske"},{"role":"aut","given":"Anne","family":"Jacob","display":"Jacob, Anne"},{"given":"Paul","role":"aut","display":"Jank, Paul","family":"Jank"},{"given":"Sibylle","role":"aut","family":"Loibl","display":"Loibl, Sibylle"},{"role":"aut","given":"Valentina","display":"Nekljudova, Valentina","family":"Nekljudova"},{"family":"Fasching","display":"Fasching, Peter A.","given":"Peter A.","role":"aut"},{"family":"Karn","display":"Karn, Thomas","role":"aut","given":"Thomas"},{"given":"Frederik","role":"aut","display":"Marmé, Frederik","family":"Marmé"},{"family":"Müller","display":"Müller, Volkmar","role":"aut","given":"Volkmar"},{"given":"Christian","role":"aut","family":"Schem","display":"Schem, Christian"},{"display":"Sinn, Bruno Valentin","family":"Sinn","role":"aut","given":"Bruno Valentin"},{"family":"Stickeler","display":"Stickeler, Elmar","role":"aut","given":"Elmar"},{"display":"Mackelenbergh, Marion Tina van","family":"Mackelenbergh","given":"Marion Tina van","role":"aut"},{"given":"Wolfgang Daniel","role":"aut","display":"Schmitt, Wolfgang Daniel","family":"Schmitt"},{"display":"Denkert, Carsten","family":"Denkert","role":"aut","given":"Carsten"},{"display":"Weichert, Wilko","family":"Weichert","given":"Wilko","role":"aut"},{"family":"Schwamborn","display":"Schwamborn, Kristina","given":"Kristina","role":"aut"}],"language":["eng"]} | ||
| SRT | |a GONCALVESJCHARACTERI2202 | ||