Adenoid cystic carcinoma of the salivary glands: a pilot study of potential therapeutic targets and characterization of the immunological tumor environment and angiogenesis
Adenoid cystic carcinoma (ACC) is a rare type of cancer commonly occurring in salivary glands. It is characterized by slow but infiltrative growth, nerve infiltration and overall poor prognosis, with late recurrence and distant metastasis. The treatment of ACC is still limited to surgery and/or (adj...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
June 2023
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| In: |
European archives of oto-rhino-laryngology and head & neck
Year: 2023, Jahrgang: 280, Heft: 6, Pages: 2937-2944 |
| ISSN: | 1434-4726 |
| DOI: | 10.1007/s00405-023-07884-3 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00405-023-07884-3 Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s00405-023-07884-3 
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| Verfasserangaben: | Ioannis Michaelides, Julian Künzel, Tobias Ettl, Philipp Beckhove, Christopher Bohr, Christoph Brochhausen, Andreas Mamilos |
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| 520 | |a Adenoid cystic carcinoma (ACC) is a rare type of cancer commonly occurring in salivary glands. It is characterized by slow but infiltrative growth, nerve infiltration and overall poor prognosis, with late recurrence and distant metastasis. The treatment of ACC is still limited to surgery and/or (adjuvant) radiotherapy. Till now no promising systemic therapy option exists. However, various studies deliver promising results after treatment with anti-angiogenetic agents, such as anti-EGFR-antibody Cetuximab or Tyrosinkinase inhibitor Lenvatinib. | ||
| 650 | 4 | |a Adenoid cystic carcinoma | |
| 650 | 4 | |a Macrophage polarization | |
| 650 | 4 | |a Neovascularization | |
| 650 | 4 | |a Salivary gland cancer | |
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| 700 | 1 | |a Mamilos, Andreas |d 1986- |e VerfasserIn |0 (DE-588)1161492232 |0 (DE-627)1024791718 |0 (DE-576)506582620 |4 aut | |
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