Towards substitution of invasive telemetry: an integrated home cage concept for unobtrusive monitoring of objective physiological parameters in rodents
This study presents a novel concept for a smart home cage design, tools, and software used to monitor the physiological parameters of mice and rats in animal-based experiments. The proposed system focuses on monitoring key clinical parameters, including heart rate, respiratory rate, and body tempera...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
September 7, 2023
|
| In: |
PLOS ONE
Year: 2023, Volume: 18, Issue: 9, Pages: 1-19 |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0286230 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1371/journal.pone.0286230 Verlag, kostenfrei, Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0286230 
|
| Author Notes: | Lucas Mösch, Janosch Kunczik, Lukas Breuer, Dorit Merhof, Peter Gass, Heidrun Potschka, Dietmar Zechner, Brigitte Vollmar, René Tolba, Christine Häger, André Bleich, Michael Czaplik, Carina Barbosa Pereira |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1899289933 | ||
| 003 | DE-627 | ||
| 005 | 20241205164326.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240821s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1371/journal.pone.0286230 |2 doi | |
| 035 | |a (DE-627)1899289933 | ||
| 035 | |a (DE-599)KXP1899289933 | ||
| 035 | |a (OCoLC)1475308630 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Mösch, Lucas |e VerfasserIn |0 (DE-588)1339548291 |0 (DE-627)1899179313 |4 aut | |
| 245 | 1 | 0 | |a Towards substitution of invasive telemetry |b an integrated home cage concept for unobtrusive monitoring of objective physiological parameters in rodents |c Lucas Mösch, Janosch Kunczik, Lukas Breuer, Dorit Merhof, Peter Gass, Heidrun Potschka, Dietmar Zechner, Brigitte Vollmar, René Tolba, Christine Häger, André Bleich, Michael Czaplik, Carina Barbosa Pereira |
| 264 | 1 | |c September 7, 2023 | |
| 300 | |b Illustrationen, Tabellen, Diagramme | ||
| 300 | |a 19 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 21.08.2024 | ||
| 520 | |a This study presents a novel concept for a smart home cage design, tools, and software used to monitor the physiological parameters of mice and rats in animal-based experiments. The proposed system focuses on monitoring key clinical parameters, including heart rate, respiratory rate, and body temperature, and can also assess activity and circadian rhythm. As the basis of the smart home cage system, an in-depth analysis of the requirements was performed, including camera positioning, imaging system types, resolution, frame rates, external illumination, video acquisition, data storage, and synchronization. Two different camera perspectives were considered, and specific camera models, including two near-infrared and two thermal cameras, were selected to meet the requirements. The developed specifications, hardware models, and software are freely available via GitHub. During the first testing phase, the system demonstrated the potential of extracting vital parameters such as respiratory and heart rate. This technology has the potential to reduce the need for implantable sensors while providing reliable and accurate physiological data, leading to refinement and improvement in laboratory animal care. | ||
| 650 | 4 | |a Animal welfare | |
| 650 | 4 | |a Cameras | |
| 650 | 4 | |a Circadian rhythms | |
| 650 | 4 | |a Computer hardware | |
| 650 | 4 | |a Light | |
| 650 | 4 | |a Near-infrared spectroscopy | |
| 650 | 4 | |a Physiological parameters | |
| 650 | 4 | |a Rodents | |
| 700 | 1 | |a Kunczik, Janosch |e VerfasserIn |4 aut | |
| 700 | 1 | |a Breuer, Lukas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Merhof, Dorit |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gass, Peter |d 1963- |e VerfasserIn |0 (DE-588)13015945X |0 (DE-627)492009694 |0 (DE-576)298033771 |4 aut | |
| 700 | 1 | |a Potschka, Heidrun |d 1968- |e VerfasserIn |0 (DE-588)1052446922 |0 (DE-627)788514059 |0 (DE-576)408167890 |4 aut | |
| 700 | 1 | |a Zechner, Dietmar |d 1969- |e VerfasserIn |0 (DE-588)1103836145 |0 (DE-627)861562283 |0 (DE-576)470784342 |4 aut | |
| 700 | 1 | |a Vollmar, Brigitte |d 1961- |e VerfasserIn |0 (DE-588)136319564 |0 (DE-627)578555565 |0 (DE-576)300960565 |4 aut | |
| 700 | 1 | |a Tolba, René |e VerfasserIn |4 aut | |
| 700 | 1 | |a Häger, Christine |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bleich, André |e VerfasserIn |4 aut | |
| 700 | 1 | |a Czaplik, Michael |d 1979- |e VerfasserIn |0 (DE-588)13582284X |0 (DE-627)571676901 |0 (DE-576)300665350 |4 aut | |
| 700 | 1 | |a Barbosa Pereira, Carina |e VerfasserIn |0 (DE-588)1162502231 |0 (DE-627)1026599342 |0 (DE-576)507436296 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t PLOS ONE |d San Francisco, California, US : PLOS, 2006 |g 18(2023), 9, Artikel-ID e0286230, Seite 1-19 |h Online-Ressource |w (DE-627)523574592 |w (DE-600)2267670-3 |w (DE-576)281331979 |x 1932-6203 |7 nnas |a Towards substitution of invasive telemetry an integrated home cage concept for unobtrusive monitoring of objective physiological parameters in rodents |
| 773 | 1 | 8 | |g volume:18 |g year:2023 |g number:9 |g elocationid:e0286230 |g pages:1-19 |g extent:19 |a Towards substitution of invasive telemetry an integrated home cage concept for unobtrusive monitoring of objective physiological parameters in rodents |
| 856 | 4 | 0 | |u https://doi.org/10.1371/journal.pone.0286230 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0286230 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20240821 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 13015945X |a Gass, Peter |m 13015945X:Gass, Peter |d 60000 |e 60000PG13015945X |k 0/60000/ |p 5 | ||
| 999 | |a KXP-PPN1899289933 |e 4569408540 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"name":{"displayForm":["Public Library of Science"]},"id":{"zdb":["2267670-3"],"eki":["523574592"],"issn":["1932-6203"]},"origin":[{"dateIssuedDisp":"2006-","publisher":"PLOS ; PLoS","dateIssuedKey":"2006","publisherPlace":"San Francisco, California, US ; Lawrence, Kan."}],"recId":"523574592","corporate":[{"roleDisplay":"Herausgebendes Organ","display":"Public Library of Science","role":"isb"}],"language":["eng"],"disp":"Towards substitution of invasive telemetry an integrated home cage concept for unobtrusive monitoring of objective physiological parameters in rodentsPLOS ONE","type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Schreibweise des Titels bis 2012: PLoS ONE","Gesehen am 20.03.19"],"part":{"pages":"1-19","issue":"9","year":"2023","extent":"19","text":"18(2023), 9, Artikel-ID e0286230, Seite 1-19","volume":"18"},"pubHistory":["1.2006 -"],"title":[{"title":"PLOS ONE","title_sort":"PLOS ONE"}]}],"physDesc":[{"extent":"19 S.","noteIll":"Illustrationen, Tabellen, Diagramme"}],"name":{"displayForm":["Lucas Mösch, Janosch Kunczik, Lukas Breuer, Dorit Merhof, Peter Gass, Heidrun Potschka, Dietmar Zechner, Brigitte Vollmar, René Tolba, Christine Häger, André Bleich, Michael Czaplik, Carina Barbosa Pereira"]},"id":{"doi":["10.1371/journal.pone.0286230"],"eki":["1899289933"]},"origin":[{"dateIssuedKey":"2023","dateIssuedDisp":"September 7, 2023"}],"recId":"1899289933","language":["eng"],"note":["Gesehen am 21.08.2024"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"person":[{"role":"aut","display":"Mösch, Lucas","roleDisplay":"VerfasserIn","given":"Lucas","family":"Mösch"},{"display":"Kunczik, Janosch","roleDisplay":"VerfasserIn","role":"aut","family":"Kunczik","given":"Janosch"},{"roleDisplay":"VerfasserIn","display":"Breuer, Lukas","role":"aut","family":"Breuer","given":"Lukas"},{"given":"Dorit","family":"Merhof","role":"aut","display":"Merhof, Dorit","roleDisplay":"VerfasserIn"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Gass, Peter","given":"Peter","family":"Gass"},{"roleDisplay":"VerfasserIn","display":"Potschka, Heidrun","role":"aut","family":"Potschka","given":"Heidrun"},{"roleDisplay":"VerfasserIn","display":"Zechner, Dietmar","role":"aut","family":"Zechner","given":"Dietmar"},{"given":"Brigitte","family":"Vollmar","role":"aut","display":"Vollmar, Brigitte","roleDisplay":"VerfasserIn"},{"given":"René","family":"Tolba","role":"aut","roleDisplay":"VerfasserIn","display":"Tolba, René"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Häger, Christine","given":"Christine","family":"Häger"},{"given":"André","family":"Bleich","role":"aut","roleDisplay":"VerfasserIn","display":"Bleich, André"},{"given":"Michael","family":"Czaplik","role":"aut","display":"Czaplik, Michael","roleDisplay":"VerfasserIn"},{"given":"Carina","family":"Barbosa Pereira","role":"aut","display":"Barbosa Pereira, Carina","roleDisplay":"VerfasserIn"}],"title":[{"title_sort":"Towards substitution of invasive telemetry","subtitle":"an integrated home cage concept for unobtrusive monitoring of objective physiological parameters in rodents","title":"Towards substitution of invasive telemetry"}]} | ||
| SRT | |a MOESCHLUCATOWARDSSUB7202 | ||