Classification of Vitamin D status based on Vitamin D metabolism: a randomized controlled trial in hypertensive patients
Circulating 25-hydroxyvitamin D (25(OH)D) is the generally accepted indicator of vitamin D status. Since hydroxylation of 25(OH)D to 24-25-dihydroxyvitamin D (24,25(OH)2D) is the first step of its catabolism, it has been suggested that a low 24,25(OH)D level and a low vitamin D metabolite ratio (VMR...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
14 March 2024
|
| In: |
Nutrients
Year: 2024, Jahrgang: 16, Heft: 6, Pages: 1-12 |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu16060839 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/nu16060839 Verlag, kostenfrei, Volltext: https://www.mdpi.com/2072-6643/16/6/839 
|
| Verfasserangaben: | Sieglinde Zelzer, Andreas Meinitzer, Dietmar Enko, Martin H. Keppel, Markus Herrmann, Verena Theiler-Schwetz, Christian Trummer, Lisa Schmitt, Andreas Tomaschitz, Patrick Sadoghi, Jutta Dierkes, Pawel Pludowski, Armin Zittermann, Winfried März and Stefan Pilz |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1899358935 | ||
| 003 | DE-627 | ||
| 005 | 20250818113700.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240822s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/nu16060839 |2 doi | |
| 035 | |a (DE-627)1899358935 | ||
| 035 | |a (DE-599)KXP1899358935 | ||
| 035 | |a (OCoLC)1475308857 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Zelzer, Sieglinde |e VerfasserIn |0 (DE-588)1163345490 |0 (DE-627)1027635938 |0 (DE-576)507927672 |4 aut | |
| 245 | 1 | 0 | |a Classification of Vitamin D status based on Vitamin D metabolism |b a randomized controlled trial in hypertensive patients |c Sieglinde Zelzer, Andreas Meinitzer, Dietmar Enko, Martin H. Keppel, Markus Herrmann, Verena Theiler-Schwetz, Christian Trummer, Lisa Schmitt, Andreas Tomaschitz, Patrick Sadoghi, Jutta Dierkes, Pawel Pludowski, Armin Zittermann, Winfried März and Stefan Pilz |
| 264 | 1 | |c 14 March 2024 | |
| 300 | |b Illustrationen | ||
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 22.08.2024 | ||
| 520 | |a Circulating 25-hydroxyvitamin D (25(OH)D) is the generally accepted indicator of vitamin D status. Since hydroxylation of 25(OH)D to 24-25-dihydroxyvitamin D (24,25(OH)2D) is the first step of its catabolism, it has been suggested that a low 24,25(OH)D level and a low vitamin D metabolite ratio (VMR), i.e., 24,25(OH)2D divided by 25(OH)D, may indicate high vitamin D requirements and provide additional diagnostic information beyond serum 25(OH)D. We, therefore, evaluated whether the classification of “functional vitamin D deficiency”, i.e., 25(OH)D below 50 nmol/L, 24,25(OH)2D below 3 nmol/L and a VMR of less than 4%, identifies individuals who benefit from vitamin D supplementation. In participants of the Styrian Vitamin D Hypertension trial, a randomized controlled trial (RCT) in 200 hypertensive patients with serum 25(OH)D below 75 nmol/L, who received either 2.800 international units of vitamin D per day or placebo over 8 weeks, 51 participants had functional vitamin D deficiency. In these individuals, there was no treatment effect of vitamin D supplementation on various parameters of bone metabolism and cardiovascular risk except for a significant effect on parathyroid hormone (PTH) and expected changes in vitamin D metabolites. In conclusion, a low vitamin D metabolite profile did not identify individuals who significantly benefit from vitamin D supplementation with regard to bone markers and cardiovascular risk factors. The clinical significance of functional vitamin D deficiency requires further evaluation in large vitamin D RCTs. | ||
| 650 | 4 | |a 24 | |
| 650 | 4 | |a 25-dihydroxyvitamin D | |
| 650 | 4 | |a classification | |
| 650 | 4 | |a deficiency | |
| 650 | 4 | |a RCT | |
| 650 | 4 | |a supplementation | |
| 650 | 4 | |a vitamin D | |
| 650 | 4 | |a vitamin D metabolite ratio | |
| 700 | 1 | |a Meinitzer, Andreas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Enko, Dietmar |e VerfasserIn |4 aut | |
| 700 | 1 | |a Keppel, Martin H. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Herrmann, Markus |e VerfasserIn |4 aut | |
| 700 | 1 | |a Theiler-Schwetz, Verena |e VerfasserIn |4 aut | |
| 700 | 1 | |a Trummer, Christian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schmitt, Lisa |e VerfasserIn |4 aut | |
| 700 | 1 | |a Tomaschitz, Andreas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sadoghi, Patrick |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dierkes, Jutta |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pludowski, Pawel |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zittermann, Armin |e VerfasserIn |4 aut | |
| 700 | 1 | |a März, Winfried |d 1958- |e VerfasserIn |0 (DE-588)1027603599 |0 (DE-627)729463605 |0 (DE-576)373454635 |4 aut | |
| 700 | 1 | |a Pilz, Stefan |e VerfasserIn |0 (DE-588)121523756 |0 (DE-627)705511073 |0 (DE-576)292753683 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nutrients |d Basel : MDPI, 2009 |g 16(2024), 6, Artikel-ID 839, Seite 1-12 |h Online-Ressource |w (DE-627)610604155 |w (DE-600)2518386-2 |w (DE-576)311829600 |x 2072-6643 |7 nnas |a Classification of Vitamin D status based on Vitamin D metabolism a randomized controlled trial in hypertensive patients |
| 773 | 1 | 8 | |g volume:16 |g year:2024 |g number:6 |g elocationid:839 |g pages:1-12 |g extent:12 |a Classification of Vitamin D status based on Vitamin D metabolism a randomized controlled trial in hypertensive patients |
| 856 | 4 | 0 | |u https://doi.org/10.3390/nu16060839 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.mdpi.com/2072-6643/16/6/839 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20240822 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 1027603599 |a März, Winfried |m 1027603599:März, Winfried |d 60000 |d 61400 |e 60000PM1027603599 |e 61400PM1027603599 |k 0/60000/ |k 1/60000/61400/ |p 14 | ||
| 999 | |a KXP-PPN1899358935 |e 456973281X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"family":"Zelzer","given":"Sieglinde","display":"Zelzer, Sieglinde","role":"aut"},{"given":"Andreas","family":"Meinitzer","role":"aut","display":"Meinitzer, Andreas"},{"given":"Dietmar","family":"Enko","role":"aut","display":"Enko, Dietmar"},{"given":"Martin H.","family":"Keppel","role":"aut","display":"Keppel, Martin H."},{"display":"Herrmann, Markus","role":"aut","family":"Herrmann","given":"Markus"},{"family":"Theiler-Schwetz","given":"Verena","display":"Theiler-Schwetz, Verena","role":"aut"},{"role":"aut","display":"Trummer, Christian","given":"Christian","family":"Trummer"},{"family":"Schmitt","given":"Lisa","display":"Schmitt, Lisa","role":"aut"},{"given":"Andreas","family":"Tomaschitz","role":"aut","display":"Tomaschitz, Andreas"},{"given":"Patrick","family":"Sadoghi","role":"aut","display":"Sadoghi, Patrick"},{"role":"aut","display":"Dierkes, Jutta","given":"Jutta","family":"Dierkes"},{"given":"Pawel","family":"Pludowski","role":"aut","display":"Pludowski, Pawel"},{"family":"Zittermann","given":"Armin","display":"Zittermann, Armin","role":"aut"},{"display":"März, Winfried","role":"aut","family":"März","given":"Winfried"},{"given":"Stefan","family":"Pilz","role":"aut","display":"Pilz, Stefan"}],"language":["eng"],"id":{"eki":["1899358935"],"doi":["10.3390/nu16060839"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"physDesc":[{"extent":"12 S.","noteIll":"Illustrationen"}],"relHost":[{"note":["Gesehen am 27.07.12"],"disp":"Classification of Vitamin D status based on Vitamin D metabolism a randomized controlled trial in hypertensive patientsNutrients","name":{"displayForm":["Molecular Diversity Preservation International (MDPI)"]},"language":["eng"],"title":[{"title_sort":"Nutrients","title":"Nutrients"}],"physDesc":[{"extent":"Online-Ressource"}],"recId":"610604155","origin":[{"dateIssuedKey":"2009","publisherPlace":"Basel","dateIssuedDisp":"2009-","publisher":"MDPI"}],"pubHistory":["1.2009 -"],"part":{"volume":"16","extent":"12","year":"2024","pages":"1-12","issue":"6","text":"16(2024), 6, Artikel-ID 839, Seite 1-12"},"type":{"bibl":"periodical","media":"Online-Ressource"},"id":{"zdb":["2518386-2"],"issn":["2072-6643"],"eki":["610604155"]}}],"title":[{"subtitle":"a randomized controlled trial in hypertensive patients","title":"Classification of Vitamin D status based on Vitamin D metabolism","title_sort":"Classification of Vitamin D status based on Vitamin D metabolism"}],"recId":"1899358935","name":{"displayForm":["Sieglinde Zelzer, Andreas Meinitzer, Dietmar Enko, Martin H. Keppel, Markus Herrmann, Verena Theiler-Schwetz, Christian Trummer, Lisa Schmitt, Andreas Tomaschitz, Patrick Sadoghi, Jutta Dierkes, Pawel Pludowski, Armin Zittermann, Winfried März and Stefan Pilz"]},"note":["Gesehen am 22.08.2024"],"origin":[{"dateIssuedDisp":"14 March 2024","dateIssuedKey":"2024"}]} | ||
| SRT | |a ZELZERSIEGCLASSIFICA1420 | ||