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Review of techniques useful for the assessment of sensory small fiber neuropathies: report from an IFCN expert group

Nerve conduction studies (NCS) are an essential aspect of the assessment of patients with peripheral neuropathies. However, conventional NCS do not reflect activation of small afferent fibers, including Aδ and C fibers. A definitive gold standard for laboratory evaluation of these fibers is still ne...

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Hauptverfasser: Verdugo, Renato J. (VerfasserIn) , Matamala, José M. (VerfasserIn) , Inui, Koji (VerfasserIn) , Kakigi, Ryusuke (VerfasserIn) , Valls-Solé, Josep (VerfasserIn) , Hansson, Per (VerfasserIn) , Nilsen, Kristian Bernhard (VerfasserIn) , Lombardi, Raffaella (VerfasserIn) , Lauria, Giuseppe (VerfasserIn) , Petropoulos, Ioannis N. (VerfasserIn) , Malik, Rayaz A. (VerfasserIn) , Treede, Rolf-Detlef (VerfasserIn) , Baumgärtner, Ulf (VerfasserIn) , Jara, Paula A. (VerfasserIn) , Campero, Mario (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: April 2022
In: Clinical neurophysiology
Year: 2022, Jahrgang: 136, Pages: 13-38
ISSN:1872-8952
DOI:10.1016/j.clinph.2022.01.002
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.clinph.2022.01.002
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S138824572200013X
Volltext
Verfasserangaben:Renato J. Verdugo, José M. Matamala, Koji Inui, Ryusuke Kakigi, Josep Valls-Solé, Per Hansson, Kristian Bernhard Nilsen, Raffaella Lombardi, Giuseppe Lauria, Ioannis N. Petropoulos, Rayaz A. Malik, Rolf-Detlef Treede, Ulf Baumgärtner, Paula A. Jara, Mario Campero
Beschreibung
Zusammenfassung:Nerve conduction studies (NCS) are an essential aspect of the assessment of patients with peripheral neuropathies. However, conventional NCS do not reflect activation of small afferent fibers, including Aδ and C fibers. A definitive gold standard for laboratory evaluation of these fibers is still needed and therefore, clinical evaluation remains fundamental in patients with small fiber neuropathies (SFN). Several clinical and research techniques have been developed for the assessment of small fiber function, such as (i) microneurography, (ii) laser evoked potentials, (iii) contact heat evoked potentials, (iv) pain-related electrically evoked potentials, (v) quantitative thermal sensory testing, (vi) skin biopsy-intraepidermal nerve fiber density and (vii) corneal confocal microscopy. The first five are physiological techniques, while the last two are morphological. They all have advantages and limitations, but the combined use of an appropriate selection of each of them would lead to gathering invaluable information for the diagnosis of SFN. In this review, we present an update on techniques available for the study of small afferent fibers and their clinical applicability. A summary of the anatomy and important physiological aspects of these pathways, and the clinical manifestations of their dysfunction is also included, in order to have a minimal common background.
Beschreibung:Online verfügbar: 19. Januar 2022, Artikelversion: 4. Februar 2022
Gesehen am 26.08.2024
Beschreibung:Online Resource
ISSN:1872-8952
DOI:10.1016/j.clinph.2022.01.002

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