Buchumschlag

Efficacy of empagliflozin in heart failure with preserved versus mid-range ejection fraction: a pre-specified analysis of EMPEROR-Preserved

The EMPEROR-Preserved trial showed that the sodium-glucose co-transporter 2 inhibitor empagliflozin significantly reduces the risk of cardiovascular death or hospitalization for heart failure (HHF) in heart failure patients with left ventricular ejection fraction (LVEF)  > 40%. Here, we report th...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Anker, Stefan (VerfasserIn) , Butler, Javed (VerfasserIn) , Usman, Muhammad Shariq (VerfasserIn) , Filippatos, Gerasimos (VerfasserIn) , Ferreira, João Pedro (VerfasserIn) , Bocchi, Edimar (VerfasserIn) , Böhm, Michael (VerfasserIn) , Rocca, Hans Pieter Brunner-La (VerfasserIn) , Choi, Dong-Ju (VerfasserIn) , Chopra, Vijay (VerfasserIn) , Chuquiure, Eduardo (VerfasserIn) , Giannetti, Nadia (VerfasserIn) , Gomez-Mesa, Juan Esteban (VerfasserIn) , Janssens, Stefan (VerfasserIn) , Januzzi, James L. (VerfasserIn) , González-Juanatey, José R. (VerfasserIn) , Merkely, Bela (VerfasserIn) , Nicholls, Stephen J. (VerfasserIn) , Perrone, Sergio V. (VerfasserIn) , Piña, Ileana L. (VerfasserIn) , Ponikowski, Piotr (VerfasserIn) , Senni, Michele (VerfasserIn) , Sim, David (VerfasserIn) , Spinar, Jindrich (VerfasserIn) , Squire, Iain (VerfasserIn) , Taddei, Stefano (VerfasserIn) , Tsutsui, Hiroyuki (VerfasserIn) , Verma, Subodh (VerfasserIn) , Vinereanu, Dragos (VerfasserIn) , Zhang, Jian (VerfasserIn) , Iwata, Tomoko (VerfasserIn) , Schnee, Janet M. (VerfasserIn) , Brückmann, Martina (VerfasserIn) , Pocock, Stuart J. (VerfasserIn) , Zannad, Faiez (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 05 December 2022
In: Nature medicine
Year: 2022, Jahrgang: 28, Heft: 12, Pages: 2512-2520
ISSN:1546-170X
DOI:10.1038/s41591-022-02041-5
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41591-022-02041-5
Verlag, kostenfrei, Volltext: http://www.nature.com/articles/s41591-022-02041-5
Volltext
Verfasserangaben:Stefan D. Anker, Javed Butler, Muhammad Shariq Usman, Gerasimos Filippatos, João Pedro Ferreira, Edimar Bocchi, Michael Böhm, Hans Pieter Brunner-La Rocca, Dong-Ju Choi, Vijay Chopra, Eduardo Chuquiure, Nadia Giannetti, Juan Esteban Gomez-Mesa, Stefan Janssens, James L. Januzzi, José R. González-Juanatey, Bela Merkely, Stephen J. Nicholls, Sergio V. Perrone, Ileana L. Piña, Piotr Ponikowski, Michele Senni, David Sim, Jindrich Spinar, Iain Squire, Stefano Taddei, Hiroyuki Tsutsui, Subodh Verma, Dragos Vinereanu, Jian Zhang, Tomoko Iwata, Janet M. Schnee, Martina Brueckmann, Stuart J. Pocock und Faiez Zannad

MARC

LEADER 00000caa a2200000 c 4500
001 1899592474
003 DE-627
005 20241205165307.0
007 cr uuu---uuuuu
008 240827s2022 xx |||||o 00| ||eng c
024 7 |a 10.1038/s41591-022-02041-5  |2 doi 
035 |a (DE-627)1899592474 
035 |a (DE-599)KXP1899592474 
035 |a (OCoLC)1475309343 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Anker, Stefan  |e VerfasserIn  |0 (DE-588)1078340498  |0 (DE-627)83835260X  |0 (DE-576)450727793  |4 aut 
245 1 0 |a Efficacy of empagliflozin in heart failure with preserved versus mid-range ejection fraction  |b a pre-specified analysis of EMPEROR-Preserved  |c Stefan D. Anker, Javed Butler, Muhammad Shariq Usman, Gerasimos Filippatos, João Pedro Ferreira, Edimar Bocchi, Michael Böhm, Hans Pieter Brunner-La Rocca, Dong-Ju Choi, Vijay Chopra, Eduardo Chuquiure, Nadia Giannetti, Juan Esteban Gomez-Mesa, Stefan Janssens, James L. Januzzi, José R. González-Juanatey, Bela Merkely, Stephen J. Nicholls, Sergio V. Perrone, Ileana L. Piña, Piotr Ponikowski, Michele Senni, David Sim, Jindrich Spinar, Iain Squire, Stefano Taddei, Hiroyuki Tsutsui, Subodh Verma, Dragos Vinereanu, Jian Zhang, Tomoko Iwata, Janet M. Schnee, Martina Brueckmann, Stuart J. Pocock und Faiez Zannad 
264 1 |c 05 December 2022 
300 |a 18 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 27.08.2024 
520 |a The EMPEROR-Preserved trial showed that the sodium-glucose co-transporter 2 inhibitor empagliflozin significantly reduces the risk of cardiovascular death or hospitalization for heart failure (HHF) in heart failure patients with left ventricular ejection fraction (LVEF)  > 40%. Here, we report the results of a pre-specified analysis that separately evaluates these patients stratified by LVEF: preserved (≥ 50%) (n = 4,005; 66.9%) or mid-range (41-49%). In patients with LVEF  ≥ 50%, empagliflozin reduced the risk of cardiovascular death or HHF (the primary endpoint) by 17% versus placebo (hazard ratio (HR) 0.83; 95% confidence interval (CI): 0.71-0.98, P = 0.024). For the key secondary endpoint, the HR for total HHF was 0.83 (95%CI: 0.66-1.04, P = 0.11). For patients with an LVEF of 41-49%, the HR for empagliflozin versus placebo was 0.71 (95%CI: 0.57-0.88, P = 0.002) for the primary outcome (Pinteraction = 0.27), and 0.57 (95%CI: 0.42-0.79, P < 0.001) for total HHF (Pinteraction = 0.06). These results, together with those from the EMPEROR-Reduced trial in patients with LVEF < 40%, support the use of empagliflozin across the full spectrum of LVEF in heart failure. 
650 4 |a Heart failure 
650 4 |a Risk factors 
700 1 |a Butler, Javed  |e VerfasserIn  |4 aut 
700 1 |a Usman, Muhammad Shariq  |e VerfasserIn  |4 aut 
700 1 |a Filippatos, Gerasimos  |e VerfasserIn  |4 aut 
700 1 |a Ferreira, João Pedro  |e VerfasserIn  |4 aut 
700 1 |a Bocchi, Edimar  |e VerfasserIn  |4 aut 
700 1 |a Böhm, Michael  |e VerfasserIn  |4 aut 
700 1 |a Rocca, Hans Pieter Brunner-La  |e VerfasserIn  |4 aut 
700 1 |a Choi, Dong-Ju  |e VerfasserIn  |4 aut 
700 1 |a Chopra, Vijay  |e VerfasserIn  |4 aut 
700 1 |a Chuquiure, Eduardo  |e VerfasserIn  |4 aut 
700 1 |a Giannetti, Nadia  |e VerfasserIn  |4 aut 
700 1 |a Gomez-Mesa, Juan Esteban  |e VerfasserIn  |4 aut 
700 1 |a Janssens, Stefan  |e VerfasserIn  |4 aut 
700 1 |a Januzzi, James L.  |e VerfasserIn  |4 aut 
700 1 |a González-Juanatey, José R.  |e VerfasserIn  |4 aut 
700 1 |a Merkely, Bela  |e VerfasserIn  |4 aut 
700 1 |a Nicholls, Stephen J.  |e VerfasserIn  |4 aut 
700 1 |a Perrone, Sergio V.  |e VerfasserIn  |4 aut 
700 1 |a Piña, Ileana L.  |e VerfasserIn  |4 aut 
700 1 |a Ponikowski, Piotr  |e VerfasserIn  |4 aut 
700 1 |a Senni, Michele  |e VerfasserIn  |4 aut 
700 1 |a Sim, David  |e VerfasserIn  |4 aut 
700 1 |a Spinar, Jindrich  |e VerfasserIn  |4 aut 
700 1 |a Squire, Iain  |e VerfasserIn  |4 aut 
700 1 |a Taddei, Stefano  |e VerfasserIn  |4 aut 
700 1 |a Tsutsui, Hiroyuki  |e VerfasserIn  |4 aut 
700 1 |a Verma, Subodh  |e VerfasserIn  |4 aut 
700 1 |a Vinereanu, Dragos  |e VerfasserIn  |4 aut 
700 1 |a Zhang, Jian  |e VerfasserIn  |4 aut 
700 1 |a Iwata, Tomoko  |e VerfasserIn  |4 aut 
700 1 |a Schnee, Janet M.  |e VerfasserIn  |4 aut 
700 1 |a Brückmann, Martina  |d 1970-  |e VerfasserIn  |0 (DE-588)121145069  |0 (DE-627)705257290  |0 (DE-576)292557736  |4 aut 
700 1 |a Pocock, Stuart J.  |e VerfasserIn  |4 aut 
700 1 |a Zannad, Faiez  |e VerfasserIn  |4 aut 
773 0 8 |i Enthalten in  |t Nature medicine  |d [New York, NY] : Springer Nature, 1995  |g 28(2022), 12 vom: Dez., Seite 2512-2520  |h Online-Ressource  |w (DE-627)301511640  |w (DE-600)1484517-9  |w (DE-576)288571274  |x 1546-170X  |7 nnas  |a Efficacy of empagliflozin in heart failure with preserved versus mid-range ejection fraction a pre-specified analysis of EMPEROR-Preserved 
773 1 8 |g volume:28  |g year:2022  |g number:12  |g month:12  |g pages:2512-2520  |g extent:18  |a Efficacy of empagliflozin in heart failure with preserved versus mid-range ejection fraction a pre-specified analysis of EMPEROR-Preserved 
856 4 0 |u https://doi.org/10.1038/s41591-022-02041-5  |x Verlag  |x Resolving-System  |z kostenfrei  |3 Volltext 
856 4 0 |u http://www.nature.com/articles/s41591-022-02041-5  |x Verlag  |z kostenfrei  |3 Volltext 
951 |a AR 
992 |a 20240827 
993 |a Article 
994 |a 2022 
998 |g 121145069  |a Brückmann, Martina  |m 121145069:Brückmann, Martina  |d 60000  |d 61000  |e 60000PB121145069  |e 61000PB121145069  |k 0/60000/  |k 1/60000/61000/  |p 33 
999 |a KXP-PPN1899592474  |e 4571025394 
BIB |a Y 
SER |a journal 
JSO |a {"title":[{"title_sort":"Efficacy of empagliflozin in heart failure with preserved versus mid-range ejection fraction","title":"Efficacy of empagliflozin in heart failure with preserved versus mid-range ejection fraction","subtitle":"a pre-specified analysis of EMPEROR-Preserved"}],"person":[{"family":"Anker","display":"Anker, Stefan","roleDisplay":"VerfasserIn","given":"Stefan","role":"aut"},{"roleDisplay":"VerfasserIn","family":"Butler","display":"Butler, Javed","given":"Javed","role":"aut"},{"given":"Muhammad Shariq","role":"aut","roleDisplay":"VerfasserIn","family":"Usman","display":"Usman, Muhammad Shariq"},{"family":"Filippatos","display":"Filippatos, Gerasimos","roleDisplay":"VerfasserIn","given":"Gerasimos","role":"aut"},{"display":"Ferreira, João Pedro","family":"Ferreira","roleDisplay":"VerfasserIn","role":"aut","given":"João Pedro"},{"family":"Bocchi","display":"Bocchi, Edimar","roleDisplay":"VerfasserIn","given":"Edimar","role":"aut"},{"roleDisplay":"VerfasserIn","family":"Böhm","display":"Böhm, Michael","given":"Michael","role":"aut"},{"role":"aut","given":"Hans Pieter Brunner-La","family":"Rocca","display":"Rocca, Hans Pieter Brunner-La","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","display":"Choi, Dong-Ju","family":"Choi","role":"aut","given":"Dong-Ju"},{"role":"aut","given":"Vijay","roleDisplay":"VerfasserIn","display":"Chopra, Vijay","family":"Chopra"},{"roleDisplay":"VerfasserIn","display":"Chuquiure, Eduardo","family":"Chuquiure","role":"aut","given":"Eduardo"},{"role":"aut","given":"Nadia","roleDisplay":"VerfasserIn","family":"Giannetti","display":"Giannetti, Nadia"},{"roleDisplay":"VerfasserIn","family":"Gomez-Mesa","display":"Gomez-Mesa, Juan Esteban","given":"Juan Esteban","role":"aut"},{"given":"Stefan","role":"aut","family":"Janssens","display":"Janssens, Stefan","roleDisplay":"VerfasserIn"},{"role":"aut","given":"James L.","display":"Januzzi, James L.","family":"Januzzi","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","family":"González-Juanatey","display":"González-Juanatey, José R.","given":"José R.","role":"aut"},{"family":"Merkely","display":"Merkely, Bela","roleDisplay":"VerfasserIn","given":"Bela","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Nicholls, Stephen J.","family":"Nicholls","given":"Stephen J.","role":"aut"},{"role":"aut","given":"Sergio V.","roleDisplay":"VerfasserIn","family":"Perrone","display":"Perrone, Sergio V."},{"role":"aut","given":"Ileana L.","family":"Piña","display":"Piña, Ileana L.","roleDisplay":"VerfasserIn"},{"role":"aut","given":"Piotr","family":"Ponikowski","display":"Ponikowski, Piotr","roleDisplay":"VerfasserIn"},{"display":"Senni, Michele","family":"Senni","roleDisplay":"VerfasserIn","role":"aut","given":"Michele"},{"role":"aut","given":"David","family":"Sim","display":"Sim, David","roleDisplay":"VerfasserIn"},{"given":"Jindrich","role":"aut","roleDisplay":"VerfasserIn","display":"Spinar, Jindrich","family":"Spinar"},{"given":"Iain","role":"aut","roleDisplay":"VerfasserIn","display":"Squire, Iain","family":"Squire"},{"family":"Taddei","display":"Taddei, Stefano","roleDisplay":"VerfasserIn","role":"aut","given":"Stefano"},{"given":"Hiroyuki","role":"aut","roleDisplay":"VerfasserIn","display":"Tsutsui, Hiroyuki","family":"Tsutsui"},{"display":"Verma, Subodh","family":"Verma","roleDisplay":"VerfasserIn","role":"aut","given":"Subodh"},{"role":"aut","given":"Dragos","roleDisplay":"VerfasserIn","display":"Vinereanu, Dragos","family":"Vinereanu"},{"given":"Jian","role":"aut","roleDisplay":"VerfasserIn","family":"Zhang","display":"Zhang, Jian"},{"role":"aut","given":"Tomoko","roleDisplay":"VerfasserIn","family":"Iwata","display":"Iwata, Tomoko"},{"roleDisplay":"VerfasserIn","family":"Schnee","display":"Schnee, Janet M.","role":"aut","given":"Janet M."},{"given":"Martina","role":"aut","display":"Brückmann, Martina","family":"Brückmann","roleDisplay":"VerfasserIn"},{"display":"Pocock, Stuart J.","family":"Pocock","roleDisplay":"VerfasserIn","given":"Stuart J.","role":"aut"},{"role":"aut","given":"Faiez","roleDisplay":"VerfasserIn","family":"Zannad","display":"Zannad, Faiez"}],"note":["Gesehen am 27.08.2024"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"physDesc":[{"extent":"18 S."}],"language":["eng"],"id":{"doi":["10.1038/s41591-022-02041-5"],"eki":["1899592474"]},"recId":"1899592474","relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"id":{"eki":["301511640"],"issn":["1546-170X"],"zdb":["1484517-9"]},"disp":"Efficacy of empagliflozin in heart failure with preserved versus mid-range ejection fraction a pre-specified analysis of EMPEROR-PreservedNature medicine","pubHistory":["1.1995 -"],"recId":"301511640","origin":[{"publisherPlace":"[New York, NY] ; New York, NY","dateIssuedKey":"2017","publisher":"Springer Nature ; Nature America Inc.","dateIssuedDisp":"2017-"}],"title":[{"title":"Nature medicine","title_sort":"Nature medicine"}],"note":["Gesehen am 24. Juli 2018"],"part":{"year":"2022","extent":"18","issue":"12","text":"28(2022), 12 vom: Dez., Seite 2512-2520","volume":"28","pages":"2512-2520"},"type":{"bibl":"periodical","media":"Online-Ressource"}}],"name":{"displayForm":["Stefan D. Anker, Javed Butler, Muhammad Shariq Usman, Gerasimos Filippatos, João Pedro Ferreira, Edimar Bocchi, Michael Böhm, Hans Pieter Brunner-La Rocca, Dong-Ju Choi, Vijay Chopra, Eduardo Chuquiure, Nadia Giannetti, Juan Esteban Gomez-Mesa, Stefan Janssens, James L. Januzzi, José R. González-Juanatey, Bela Merkely, Stephen J. Nicholls, Sergio V. Perrone, Ileana L. Piña, Piotr Ponikowski, Michele Senni, David Sim, Jindrich Spinar, Iain Squire, Stefano Taddei, Hiroyuki Tsutsui, Subodh Verma, Dragos Vinereanu, Jian Zhang, Tomoko Iwata, Janet M. Schnee, Martina Brueckmann, Stuart J. Pocock und Faiez Zannad"]},"origin":[{"dateIssuedDisp":"05 December 2022","dateIssuedKey":"2022"}]} 
SRT |a ANKERSTEFAEFFICACYOF0520 

Ähnliche Einträge