Concatenating structural constraint effects at in for the sequential generation, stabilization, and transfer of acyclic aminocarbenes
Structural constraint approaches have been employed toward different ends in recent years, from augmenting the nucleophilicity in pyramidalized low-valent p-block compounds to enhancing the Lewis acidities at planarized tetravalent p-block elements. While previous studies exploited these effects sep...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2024
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| In: |
Journal of the American Chemical Society
Year: 2024, Volume: 146, Issue: 16, Pages: 11515-11522 |
| ISSN: | 1520-5126 |
| DOI: | 10.1021/jacs.4c02446 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1021/jacs.4c02446
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| Author Notes: | Heiko Ruppert, Arne Meister, Ronja Pfretzschner, André Faria Vieira, Lutz Greb |
| Summary: | Structural constraint approaches have been employed toward different ends in recent years, from augmenting the nucleophilicity in pyramidalized low-valent p-block compounds to enhancing the Lewis acidities at planarized tetravalent p-block elements. While previous studies exploited these effects separately, this work introduces a strategy to concatenate structural constraint approaches at individual stages of a reaction sequence in a row to unlock a synthetic path unattainable by conventional methodologies. The boosted nucleophilicity resulting from the constrained tetracoordinated calix[4]pyrrolato stannate(II) dianion enables the reductive formation of sterically unprotected acyclic aminocarbenes. These amino carbenes are stabilized at the concomitantly formed square-planar stannane(IV) as air-stable adducts. Transfer of the carbenes onto copper(I) by cooperativity of the calix[4]pyrrole ligand finalizes this protocol to hitherto unreported yet prototypical carbene complexes. Detailed spectroscopic and quantum theoretical analyses establish the synergy of structural constraints and element-ligand cooperation as the linchpin to this reaction path and its selectivity. |
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| Item Description: | Online veröffentlicht: 11. April 2024 Gesehen am 28.08.2024 |
| Physical Description: | Online Resource |
| ISSN: | 1520-5126 |
| DOI: | 10.1021/jacs.4c02446 |