Pharmacokinetics of orally administered zidovudine in HIV-infected children and adults
The pharmacokinetics of oral zidovudine in HIV-infected children and adults are reported. Fourty-six patients were investigated. For data analysis three groups of similar size were formed: young children 4 months −4 years, n=15 (group 1), older children up to 13 years, n=16 (group 2) and young adult...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
November 1995
|
| In: |
Infection
Year: 1995, Volume: 23, Issue: 6, Pages: 344-348 |
| ISSN: | 1439-0973 |
| DOI: | 10.1007/BF01713563 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/BF01713563
|
| Author Notes: | U. Wintergerst, B. Rolinski, Gundula Notheis, B.H. Belohradsky, F.-D. Goebel, Ilse Grosch-Wörner, Mechtild Vocks-Hauck, V. Wahn, K.-M. Debatin, the German Multicenter Study AIDS and Children |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 190234801X | ||
| 003 | DE-627 | ||
| 005 | 20241205171607.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240911s1995 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/BF01713563 |2 doi | |
| 035 | |a (DE-627)190234801X | ||
| 035 | |a (DE-599)KXP190234801X | ||
| 035 | |a (OCoLC)1475311408 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Wintergerst, Uwe |e VerfasserIn |0 (DE-588)1341671585 |0 (DE-627)1902348176 |4 aut | |
| 245 | 1 | 0 | |a Pharmacokinetics of orally administered zidovudine in HIV-infected children and adults |c U. Wintergerst, B. Rolinski, Gundula Notheis, B.H. Belohradsky, F.-D. Goebel, Ilse Grosch-Wörner, Mechtild Vocks-Hauck, V. Wahn, K.-M. Debatin, the German Multicenter Study AIDS and Children |
| 264 | 1 | |c November 1995 | |
| 300 | |a 5 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 11.09.2024 | ||
| 520 | |a The pharmacokinetics of oral zidovudine in HIV-infected children and adults are reported. Fourty-six patients were investigated. For data analysis three groups of similar size were formed: young children 4 months −4 years, n=15 (group 1), older children up to 13 years, n=16 (group 2) and young adults, n=15 (group 3). After a single oral dose repeated blood samples were taken 1/2 hourly during a period of 4 hours and zidovudine concentrations in plasma were determined by high performance liquid chromatography. For better comparison of dose dependent parameters peak concentrations (Cmax) and the area under the time-concentration curves (AUC) were normalized either to the dose/body weight (bw) or the dose/body surface area (bs), respectively. Time to reach peak concentrations and mean terminal elimination half-life times (t1/2β=63.4±47.6, 74.9±54.9 and 56.9±16.4 min in group 1, 2 and 3, respectively, mean ± SD) were not significantly different between the three groups. With normalization to dose/bw young children in comparison to adults had significantly lower Cmax (2.7±1.3 vs. 4.6±2.4 µmol/l, p=0.016) and AUC (226±108 vs. 373±224 µmol·min/l, p=0.038). Group 2 gave intermediate values. However, with normalization to dose/bs differences in Cmax (6.5±3.3, 7.3±4.2 and 6.8±3.6 µmol/l, in group 1, 2, and 3, respectively) and AUC (563±313, 691±351 and 555±342 µmol·min/l, in group 1, 2 and 3) were not significant between the three groups. It is likely that changes in body water content with age may account for most of these differences observed. In conclusion, a similar pharmacokinetic profile was found in children older than 3 months as compared to older children or adults. | ||
| 650 | 4 | |a Body Water Content | |
| 650 | 4 | |a Oral Zidovudine | |
| 650 | 4 | |a Reach Peak Concentration | |
| 650 | 4 | |a Repeated Blood Sample | |
| 650 | 4 | |a Zidovudine | |
| 700 | 1 | |a Rolinski, B. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Notheis, Gundula |e VerfasserIn |4 aut | |
| 700 | 1 | |a Belohradsky, B. H. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Goebel, F.-D. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Grosch-Wörner, Ilse |e VerfasserIn |4 aut | |
| 700 | 1 | |a Vocks-Hauck, Mechtild |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wahn, V. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Debatin, Klaus-Michael |d 1952- |e VerfasserIn |0 (DE-588)109442288 |0 (DE-627)507956451 |0 (DE-576)289642809 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Infection |d München : Urban & Vogel, 1973 |g 23(1995), 6, Seite 344-348 |h Online-Ressource |w (DE-627)31236945X |w (DE-600)2006315-5 |w (DE-576)090889487 |x 1439-0973 |7 nnas |a Pharmacokinetics of orally administered zidovudine in HIV-infected children and adults |
| 773 | 1 | 8 | |g volume:23 |g year:1995 |g number:6 |g pages:344-348 |g extent:5 |a Pharmacokinetics of orally administered zidovudine in HIV-infected children and adults |
| 856 | 4 | 0 | |u https://doi.org/10.1007/BF01713563 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20240911 | ||
| 993 | |a Article | ||
| 994 | |a 1995 | ||
| 998 | |g 109442288 |a Debatin, Klaus-Michael |m 109442288:Debatin, Klaus-Michael |d 910000 |d 910500 |e 910000PD109442288 |e 910500PD109442288 |k 0/910000/ |k 1/910000/910500/ |p 9 |y j | ||
| 999 | |a KXP-PPN190234801X |e 457884868X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"recId":"190234801X","type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 11.09.2024"],"title":[{"title":"Pharmacokinetics of orally administered zidovudine in HIV-infected children and adults","title_sort":"Pharmacokinetics of orally administered zidovudine in HIV-infected children and adults"}],"person":[{"role":"aut","display":"Wintergerst, Uwe","roleDisplay":"VerfasserIn","given":"Uwe","family":"Wintergerst"},{"given":"B.","family":"Rolinski","role":"aut","display":"Rolinski, B.","roleDisplay":"VerfasserIn"},{"role":"aut","display":"Notheis, Gundula","roleDisplay":"VerfasserIn","given":"Gundula","family":"Notheis"},{"family":"Belohradsky","given":"B. H.","display":"Belohradsky, B. H.","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Goebel","given":"F.-D.","display":"Goebel, F.-D.","roleDisplay":"VerfasserIn","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Grosch-Wörner, Ilse","role":"aut","family":"Grosch-Wörner","given":"Ilse"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Vocks-Hauck, Mechtild","given":"Mechtild","family":"Vocks-Hauck"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Wahn, V.","given":"V.","family":"Wahn"},{"roleDisplay":"VerfasserIn","display":"Debatin, Klaus-Michael","role":"aut","family":"Debatin","given":"Klaus-Michael"}],"relHost":[{"pubHistory":["1.1973 -"],"part":{"extent":"5","text":"23(1995), 6, Seite 344-348","volume":"23","issue":"6","pages":"344-348","year":"1995"},"disp":"Pharmacokinetics of orally administered zidovudine in HIV-infected children and adultsInfection","note":["Gesehen am 05.12.05"],"type":{"bibl":"periodical","media":"Online-Ressource"},"language":["eng"],"recId":"31236945X","title":[{"title_sort":"Infection","title":"Infection"}],"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"publisherPlace":"München ; Berlin ; Heidelberg","dateIssuedKey":"1973","publisher":"Urban & Vogel ; Springer","dateIssuedDisp":"1973-"}],"id":{"issn":["1439-0973"],"eki":["31236945X"],"zdb":["2006315-5"]}}],"physDesc":[{"extent":"5 S."}],"id":{"doi":["10.1007/BF01713563"],"eki":["190234801X"]},"origin":[{"dateIssuedDisp":"November 1995","dateIssuedKey":"1995"}],"name":{"displayForm":["U. Wintergerst, B. Rolinski, Gundula Notheis, B.H. Belohradsky, F.-D. Goebel, Ilse Grosch-Wörner, Mechtild Vocks-Hauck, V. Wahn, K.-M. Debatin, the German Multicenter Study AIDS and Children"]}} | ||
| SRT | |a WINTERGERSPHARMACOKI1995 | ||